Site of chemical modifications in CpG containing phosphorothioate oligodeoxynucleotide modulates its immunostimulatory activity.

[1]  S. Agrawal,et al.  Mixed backbone oligonucleotides: improvement in oligonucleotide-induced toxicity in vivo. , 1998, Antisense & nucleic acid drug development.

[2]  S. Agrawal,et al.  Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice. , 1997, Antisense & nucleic acid drug development.

[3]  G. Weiner,et al.  Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. , 1997, Blood.

[4]  D. Klinman,et al.  Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway. , 1996, Journal of immunology.

[5]  S. Agrawal,et al.  Effect of different chemically modified oligodeoxynucleotides on immune stimulation. , 1996, Biochemical Pharmacology.

[6]  A. Krieg,et al.  IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. , 1996, Journal of immunology.

[7]  G. Bishop,et al.  CpG motifs in bacterial DNA trigger direct B-cell activation , 1995, Nature.

[8]  J. Lisziewicz,et al.  Study of antisense oligonucleotide phosphorothioates containing segments of oligodeoxynucleotides and 2′-o- methyloligoribonucleotides , 1994 .

[9]  D. Pisetsky,et al.  Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus. , 1994, Life sciences.

[10]  R. Branda,et al.  Immune stimulation by an antisense oligomer complementary to the rev gene of HIV-1. , 1993, Biochemical pharmacology.

[11]  Osamu Yano,et al.  Oligonucleotide Sequences Required for Natural Killer Cell Activation , 1992, Japanese journal of cancer research : Gann.

[12]  E. Kuramoto,et al.  Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity. , 1992, Journal of immunology.

[13]  E. Kuramoto,et al.  Antitumor Activity of Synthetic Oligonucleotides with Sequences from cDNA Encoding Proteins of Mycobacterium bovis BCG , 1992, Japanese journal of cancer research : Gann.

[14]  E. Kuramoto,et al.  Synthetic Oligonucleotides with Particular Base Sequences from the cDNA Encoding Proteins of Mycobacterium bovis BCG Induce Interferons and Activate Natural Killer Cells , 1992, Microbiology and immunology.

[15]  D. Pisetsky,et al.  Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. , 1991, Journal of immunology.