Manipulation of cytokine networks in transplantation: false hope or realistic opportunity for tolerance?

[1]  H. Weiner,et al.  Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. , 1994, Science.

[2]  M. Picard,et al.  LEW-to-F344 carotid artery allografts: analysis of a rat model of posttransplant vascular injury involving cell-mediated and humoral responses. , 1995, Transplantation.

[3]  M. Dallman,et al.  Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction , 1991, The Journal of experimental medicine.

[4]  J. Phillips,et al.  T cell regulation in adult transplantation tolerance. , 1996, Journal of immunology.

[5]  S. Akira,et al.  Cytokine signal transduction , 1994, Cell.

[6]  C. Figdor,et al.  Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression , 1991, The Journal of experimental medicine.

[7]  A. Shaked,et al.  Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Immunosuppression with TGF-beta 1 or vIL-10. , 1995, Transplantation.

[8]  P. Nickerson,et al.  IL-2 knockout recipient mice reject islet cell allografts. , 1995, Journal of immunology.

[9]  K. Grabstein,et al.  PRECURSOR FREQUENCY AND LYTIC SPECIFICITY OF INTERLEUKIN 2 AND INTERLEUKIN 4‐RESPONSIVE MURINE LYMPHOCYTES , 1990, Transplantation.

[10]  P. Huie,et al.  RANTES chemokine expression in cell-mediated transplant rejection of the kidney , 1994, The Lancet.

[11]  J. Lanchbury,et al.  Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and -independent binding mechanisms. , 1991, Journal of immunology.

[12]  P. Nickerson,et al.  Analysis of cytokine transcripts in pancreatic islet cell allografts during rejection and tolerance induction. , 1993, Transplantation proceedings.

[13]  R. Steinman,et al.  The dendritic cell system and its role in immunogenicity. , 1991, Annual review of immunology.

[14]  W. Paul,et al.  B-cell stimulatory factor-1/interleukin 4. , 1987, Annual review of immunology.

[15]  P. Linsley,et al.  Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways , 1996, Nature.

[16]  W. Baldwin,et al.  CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines. , 1993, Journal of immunology.

[17]  K. Grabstein,et al.  Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor , 1987, Nature.

[18]  T. Strom,et al.  Interleukin-2 receptor-directed therapies: antibody- or cytokine-based targeting molecules. , 1994, Advances in nephrology from the Necker Hospital.

[19]  I. Horak,et al.  Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting , 1991, Nature.

[20]  R. Flavell,et al.  The selective ablation of interleukin 2-producing cells isolated from transgenic mice , 1993, The Journal of experimental medicine.

[21]  P. Nickerson,et al.  Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts. , 1993, Journal of immunology.

[22]  Smith Wm,et al.  Acute retinal necrosis in a renal allograft recipient--an unusual manifestation of cytomegalovirus infection. , 1993 .

[23]  A. Zlotnik,et al.  IL-10: a novel cytotoxic T cell differentiation factor. , 1991, Journal of immunology.

[24]  T. Waldmann,et al.  IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. , 1996, Immunity.

[25]  S. Wahl,et al.  Transforming growth factor beta: the good, the bad, and the ugly , 1994, The Journal of experimental medicine.

[26]  Kenneth M. Murphy,et al.  Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent , 1993 .

[27]  J. Bluestone,et al.  IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2. , 1994, Journal of immunology.

[28]  R. Coffman,et al.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. , 1986, Journal of immunology.

[29]  M. Alderson,et al.  Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood , 1990, The Journal of experimental medicine.

[30]  B. Konieczny,et al.  Heart allografts in murine systems. The differential activation of Th2-like effector cells in peripheral tolerance. , 1992, Transplantation.

[31]  C. Figdor,et al.  IL-4 inhibits IL-2-mediated induction of human lymphokine-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte cultures. , 1988, Journal of immunology.

[32]  P. Nickerson,et al.  Prolonged islet allograft acceptance in the absence of interleukin 4 expression. , 1996, Transplant immunology.

[33]  M. Lipman,et al.  Heightened intragraft CTL gene expression in acutely rejecting renal allografts. , 1994, Journal of immunology.

[34]  A. O’Garra,et al.  Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production. , 1993, Journal of immunology.

[35]  P. Linsley,et al.  IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. , 1993, Journal of immunology.

[36]  P. Linsley,et al.  CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2 , 1995, The Journal of experimental medicine.

[37]  A. Kelso Th1 and Th2 subsets: paradigms lost? , 1995, Immunology today.

[38]  D. Kioussis,et al.  "Infectious" transplantation tolerance , 1993, Science.

[39]  J. Korn,et al.  Regulation of ICAM-1 expression and function in human dermal fibroblasts by IL-4. , 1992, Journal of immunology.

[40]  P. Nickerson,et al.  Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. , 1995, Journal of immunology.

[41]  W. Paul,et al.  Lymphocyte responses and cytokines , 1994, Cell.

[42]  S. Ho,et al.  Regulatory effects of transforming growth factor-beta on IL-2- and IL-4-dependent T cell-cycle progression. , 1990, Journal of immunology.

[43]  C. Figdor,et al.  IL-10 stimulates monocyte Fc gamma R surface expression and cytotoxic activity. Distinct regulation of antibody-dependent cellular cytotoxicity by IFN-gamma, IL-4, and IL-10. , 1992, Journal of immunology.

[44]  M. Hallet,et al.  PERIPHERAL TOLERANCE OF AN ALLOGRAFT IN ADULT RATS—CHARACTERIZATION BY LOW INTERLEUKIN‐2 AND INTERFERON‐γ mRNA LEVELS AND BY STRONG ACCUMULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX TRANSCRIPTS IN THE GRAFT , 1992, Transplantation.

[45]  M. Dallman,et al.  Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway , 1991, The Journal of experimental medicine.

[46]  N. Sarvetnick,et al.  Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction. , 1994, The Journal of clinical investigation.

[47]  C Benoist,et al.  T helper cell subsets in insulin-dependent diabetes. , 1995, Science.

[48]  B. Masinovsky,et al.  IL-4 acts synergistically with IL-1 beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1. , 1990, Journal of immunology.

[49]  E. Worthey,et al.  T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction. , 1995, Journal of immunology.

[50]  P. Campbell,et al.  Interleukin-4 is chemotactic for mouse macrophages. , 1992, Cellular immunology.

[51]  W. Leonard,et al.  Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans , 1993, Cell.

[52]  N. Tanaka,et al.  Cloning of the gamma chain of the human IL-2 receptor. , 1992, Science.

[53]  T. Mosmann,et al.  The expanding universe of T-cell subsets: Th1, Th2 and more. , 1996, Immunology today.

[54]  T. Waldmann The IL-2/IL-2 receptor system: a target for rational immune intervention. , 1993, Trends in pharmacological sciences.

[55]  H. Savelkoul,et al.  Cytokine antagonists and their potential therapeutic use. , 1994, Immunology today.

[56]  S. Ziegler,et al.  Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. , 1993, Science.

[57]  G. Schönrich,et al.  Multiple levels of peripheral tolerance. , 1993, Immunology today.

[58]  K. Arai,et al.  Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. , 1993, Science.