Targeting mitochondria metabolism for cancer therapy.

[1]  Zhandong Liu,et al.  Serine catabolism regulates mitochondrial redox control during hypoxia. , 2014, Cancer discovery.

[2]  John M. Asara,et al.  Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function , 2014, Nature.

[3]  T. Copetti,et al.  A mitochondrial switch promotes tumor metastasis. , 2014, Cell reports.

[4]  M. Pollak,et al.  Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria , 2014, The Biochemical journal.

[5]  K. Struhl,et al.  Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells , 2014, Proceedings of the National Academy of Sciences.

[6]  S. Dhar,et al.  Detouring of cisplatin to access mitochondrial genome for overcoming resistance , 2014, Proceedings of the National Academy of Sciences.

[7]  M. Pollak.  Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment , 2014, Nature Medicine.

[8]  N. Chandel.  Mitochondria as signaling organelles , 2014, BMC Biology.

[9]  N. Chandel,et al.  ROS Function in Redox Signaling and Oxidative Stress , 2014, Current Biology.

[10]  Andrea Glasauer,et al.  Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis , 2014, eLife.

[11]  T. Shlomi,et al.  Quantitative flux analysis reveals folate-dependent NADPH production , 2014, Nature.

[12]  Adam M. Feist,et al.  Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. , 2014, Molecular cell.

[13]  D. Sabatini,et al.  Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides , 2014, Nature.

[14]  V. Gogvadze,et al.  Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments , 2014, Nature Communications.

[15]  E. Larsson,et al.  Antioxidants Accelerate Lung Cancer Progression in Mice , 2014, Science Translational Medicine.

[16]  V. Mootha,et al.  Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer , 2014, Nature Communications.

[17]  Andrea Glasauer,et al.  Targeting SOD1 reduces experimental non–small-cell lung cancer. , 2014, The Journal of clinical investigation.

[18]  Tomer Shlomi,et al.  Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia , 2013, Molecular systems biology.

[19]  T. Mak,et al.  Modulation of oxidative stress as an anticancer strategy , 2013, Nature Reviews Drug Discovery.

[20]  R. Deberardinis,et al.  Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells , 2013, Journal of Molecular Medicine.

[21]  E. White,et al.  Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. , 2013, Cancer discovery.

[22]  L. Cantley,et al.  Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma , 2013, Proceedings of the National Academy of Sciences.

[23]  Tomoyoshi Soga,et al.  Oncometabolites: linking altered metabolism with cancer. , 2013, The Journal of clinical investigation.

[24]  Ralph J DeBerardinis,et al.  Glutamine and cancer: cell biology, physiology, and clinical opportunities. , 2013, The Journal of clinical investigation.

[25]  R. Deberardinis,et al.  The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. , 2013, Molecular cell.

[26]  J. Locasale.  Serine, glycine and one-carbon units: cancer metabolism in full circle , 2013, Nature Reviews Cancer.

[27]  S. Ivanov,et al.  Does scavenging of mitochondrial superoxide attenuate cancer prosurvival signaling pathways? , 2013, Antioxidants & redox signaling.

[28]  D. Hardie,et al.  AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer , 2013, Diabetes.

[29]  G. Stephanopoulos,et al.  Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. , 2013, Cancer research.

[30]  G. Pond,et al.  Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK , 2013, British Journal of Cancer.

[31]  W. Kaelin,et al.  Influence of Metabolism on Epigenetics and Disease , 2013, Cell.

[32]  P. Puigserver,et al.  PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. , 2013, Cancer cell.

[33]  Jun S. Song,et al.  Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. , 2013, Cancer cell.

[34]  Liu Wei,et al.  LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. , 2013, Cancer cell.

[35]  M. Schwab,et al.  Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects. , 2013, Trends in pharmacological sciences.

[36]  J. Maris,et al.  ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. , 2012, Cancer cell.

[37]  N. Chandel,et al.  Physiological roles of mitochondrial reactive oxygen species. , 2012, Molecular cell.

[38]  A. Kishan,et al.  Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. , 2012, Cancer cell.

[39]  D. Wallace.  Mitochondria and cancer , 2012, Nature Reviews Cancer.

[40]  M. Herlyn,et al.  Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s. , 2012, Cancer cell.

[41]  D. Sabatini,et al.  Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson , 2012, Nature Medicine.

[42]  Saroj Niraula,et al.  Metformin in cancer: translational challenges. , 2012, Journal of molecular endocrinology.

[43]  J. Joseph,et al.  Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. , 2012, Cancer research.

[44]  C. Dang.  Links between metabolism and cancer. , 2012, Genes & development.

[45]  P. Ward,et al.  Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. , 2012, Cancer cell.

[46]  A. Thompson,et al.  Phenformin as prophylaxis and therapy in breast cancer xenografts , 2012, British Journal of Cancer.

[47]  M. Pollak.  The insulin and insulin-like growth factor receptor family in neoplasia: an update , 2012, Nature Reviews Cancer.

[48]  A. Lane,et al.  Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. , 2012, Cell metabolism.

[49]  Jesse M. Platt,et al.  Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability , 2011, Proceedings of the National Academy of Sciences.

[50]  G. Giaever,et al.  Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. , 2011, Cancer cell.

[51]  Christian M. Metallo,et al.  Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia , 2011, Nature.

[52]  W. Marston Linehan,et al.  Reductive carboxylation supports growth in tumor cells with defective mitochondria , 2011, Nature.

[53]  M. V. Vander Heiden,et al.  Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. , 2011, Annual review of cell and developmental biology.

[54]  T. Golub,et al.  Selective killing of cancer cells with a small molecule targeting stress response to ROS , 2011, Nature.

[55]  Scott E. Kern,et al.  Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis , 2011, Nature.

[56]  Domenico L Gatti,et al.  Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation. , 2011, Cell metabolism.

[57]  Chi V. Dang,et al.  Otto Warburg's contributions to current concepts of cancer metabolism , 2011, Nature Reviews Cancer.

[58]  H. Coller,et al.  Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. , 2011, Genes & development.

[59]  C. Dang,et al.  Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. , 2010, Cancer cell.

[60]  R. Memmott,et al.  Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis , 2010, Cancer Prevention Research.

[61]  V. Fung,et al.  A double‐blind, placebo‐controlled study to assess the mitochondria‐targeted antioxidant MitoQ as a disease‐modifying therapy in Parkinson's disease , 2010, Movement disorders : official journal of the Movement Disorder Society.

[62]  W. Wheaton,et al.  Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity , 2010, Proceedings of the National Academy of Sciences.

[63]  Jeffrey W. Smith,et al.  Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation , 2010, Molecular and Cellular Biology.

[64]  R. Deberardinis,et al.  Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer , 2010, Oncogene.

[65]  Justin R. Cross,et al.  ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation , 2009, Science.

[66]  Jennifer E. Van Eyk,et al.  c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism , 2009, Nature.

[67]  Anthony Mancuso,et al.  Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction , 2008, Proceedings of the National Academy of Sciences.

[68]  Ralph Weissleder,et al.  Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers , 2008, Nature Medicine.

[69]  Kunihiro Hosono,et al.  Metformin suppresses intestinal polyp growth in ApcMin/+ mice , 2008, Cancer science.

[70]  A. Lane,et al.  Targeting aspartate aminotransferase in breast cancer , 2008, Breast Cancer Research.

[71]  J. Hayashi,et al.  ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis , 2008, Science.

[72]  N. Chandel,et al.  Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis , 2007, Molecular and Cellular Biology.

[73]  B. Viollet,et al.  Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. , 2007, Cancer research.

[74]  C. Gluud,et al.  Surviving antioxidant supplements. , 2007, Journal of the National Cancer Institute.

[75]  Robin A. J. Smith,et al.  Targeting antioxidants to mitochondria by conjugation to lipophilic cations. , 2007, Annual review of pharmacology and toxicology.

[76]  Jinsong Liu,et al.  Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. , 2006, Cancer cell.

[77]  D. Wallace.  A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine , 2005, Annual review of genetics.

[78]  Stephen W. Fesik,et al.  Promoting apoptosis as a strategy for cancer drug discovery , 2005, Nature Reviews Cancer.

[79]  Daniel E Bauer,et al.  ATP citrate lyase inhibition can suppress tumor cell growth. , 2005, Cancer cell.

[80]  Zhijian J. Chen,et al.  Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 , 2005, Cell.

[81]  Jesse R. Dixon,et al.  Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. , 2005, Molecular cell.

[82]  Dario R Alessi,et al.  Metformin and reduced risk of cancer in diabetic patients , 2005, BMJ : British Medical Journal.

[83]  John A. Hall,et al.  mtDNA mutations increase tumorigenicity in prostate cancer. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[84]  R. Gillies,et al.  Why do cancers have high aerobic glycolysis? , 2004, Nature Reviews Cancer.

[85]  M. Guppy,et al.  Cancer metabolism: facts, fantasy, and fiction. , 2004, Biochemical and biophysical research communications.

[86]  Dai Fukumura,et al.  Dissecting tumour pathophysiology using intravital microscopy , 2002, Nature Reviews Cancer.

[87]  M. Owen,et al.  Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. , 2000, The Biochemical journal.

[88]  M. Rigoulet,et al.  Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I* , 2000, The Journal of Biological Chemistry.

[89]  Mark H. Ellisman,et al.  NH2-Terminal Targeting Motifs Direct Dual Specificity A-Kinase–anchoring Protein 1 (D-AKAP1) to Either Mitochondria or Endoplasmic Reticulum , 1999, The Journal of cell biology.

[90]  B. Ames,et al.  Oxidants, antioxidants, and the degenerative diseases of aging. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[91]  W. Rumsey,et al.  Cellular energetics and the oxygen dependence of respiration in cardiac myocytes isolated from adult rat. , 1990, The Journal of biological chemistry.

[92]  B. Ames,et al.  Oxygen radicals and human disease. , 1987, Annals of internal medicine.

[93]  O. Warburg.  On respiratory impairment in cancer cells. , 1956, Science.

[94]  O. Warburg.  [Origin of cancer cells]. , 1956, Oncologia.

[95]  S. Weinhouse,et al.  Metabolism of neoplastic tissue. I. The oxidation of carbohydrate and fatty acids in transplanted tumors. , 1951, Cancer research.

[96]  S. Weinhouse.  Studies on the fate of isotopically labeled metabolites in the oxidative metabolism of tumors. , 1951, Cancer research.

[97]  W. D. Martin,et al.  Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. , 2012, The American journal of pathology.

[98]  Sébastien Bonnet,et al.  A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. , 2007, Cancer cell.

[99]  D. Albanes,et al.  The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. , 1994, The New England journal of medicine.

[100]  S. Weinhouse,et al.  Metabolism of neoplastic tissue. III. Diphosphopyridine nucleotide requirements for oxidations by mitochondria of neoplastic and non-neoplastic tissues. , 1953, Cancer research.

[101]  S. Weinhouse,et al.  Metabolism of neoplastic tissue. II. A survey of enzymes of the citric acid cycle in transplanted tumors. , 1952, Cancer research.

[102]  Christian M. Metallo,et al.  Molecular Systems Biology Peer Review Process File Oncogenic K-ras Decouples Glucose and Glutamine Metabolism to Support Cancer Cell Growth Transaction Report , 2022 .