Trends in childhood leukemia in Basrah, Iraq, 1993-2007.

OBJECTIVES Through a sister-university relationship between the University of Basrah and the University of Washington, we analyzed Ibn Ghazwan Hospital's leukemia registry data to evaluate trends in childhood leukemia since 1993. METHODS We documented leukemia cases among children aged 0 to 14 years for each of the last 15 years. Population data were obtained from a 1997 census and various subsequent estimates to calculate rates. RESULTS We observed 698 cases of childhood leukemia between 1993 and 2007, ranging between 15 cases (2.6 per 100 000 annual rate) in the first year and 56 cases (6.9 per 100 000 annual rate) in the final year, reaching a peak of 97 cases in 2006 (12.2 per 100 000 annual rate). CONCLUSIONS Childhood leukemia rates in Basrah more than doubled over a 15-year period. The test for trend was significant (P = .03). Basrah's childhood leukemia rate compared unfavorably with neighboring Kuwait and nearby Oman, as well as the United States, the European Union, and other countries.

[1]  J. Shaham,et al.  Parental Occupational Exposure and the Risk of Acute Lymphoblastic Leukemia in Offspring in Israel , 2006, Journal of occupational and environmental medicine.

[2]  L. Ries,et al.  Cancer surveillance series: recent trends in childhood cancer incidence and mortality in the United States. , 1999, Journal of the National Cancer Institute.

[3]  J. Ross,et al.  Trends in childhood cancer incidence in the U.S. (1992–2004) , 2008, Cancer.

[4]  H. Knox-macaulay,et al.  Descriptive epidemiology of de novo acute leukaemia in the Sultanate of Oman. , 2000, Leukemia research.

[5]  H Austin,et al.  Benzene and leukemia. A review of the literature and a risk assessment. , 1988, American journal of epidemiology.

[6]  J. Stockman.  Geographical Patterns and Time Trends of Cancer Incidence and Survival Among Children and Adolescents in Europe Since the 1970s (the ACCIS Project): An Epidemiological Study , 2006 .

[7]  R. Haden.  The leukemias. , 1988, Pediatric clinics of North America.

[8]  C. Infante-Rivard,et al.  Drinking Water Contaminants and Childhood Leukemia , 2001, Epidemiology.

[9]  I M Madany,et al.  Polycyclic aromatic hydrocarbons, nickel and vanadium in air particulate matter in Bahrain during the burning of oil fields in Kuwait. , 1992, The Science of the total environment.

[10]  B. Armstrong,et al.  Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study , 2001, The Lancet.

[11]  H. Dohy,et al.  Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma, 1950-1987. , 1994, Radiation research.

[12]  C. Magnani,et al.  Parental Occupation and Other Environmental Factors in the Etiology of Leukemias and Non-Hodgkin'S Lymphomas in Childhood: A Case-Control Study , 1990, Tumori.

[13]  N. Pearce,et al.  Bayesian methods for early detection of changes in childhood cancer incidence: trends for acute lymphoblastic leukaemia are consistent with an infectious aetiology. , 2006, European journal of cancer.

[14]  Han K. Kang,et al.  Mortality in US Army Gulf War veterans exposed to 1991 Khamisiyah chemical munitions destruction. , 2005, American journal of public health.

[15]  I. Shah,et al.  Sanctions and childhood mortality in Iraq , 2000, The Lancet.

[16]  C. la Vecchia,et al.  Childhood leukaemias and lymphomas in Greece (1996–2006): a nationwide registration study , 2008, Archives of Disease in Childhood.

[17]  J. Mejía-Aranguré,et al.  Incidence of cancer in children residing in ten jurisdictions of the Mexican Republic: importance of the Cancer registry (a population-based study) , 2007, BMC Cancer.

[18]  R. Sadda.  Maxillofacial war injuries during the Iraq-Iran War: an analysis of 300 cases. , 2003, International journal of oral and maxillofacial surgery.

[19]  G. Bunin.  Nongenetic causes of childhood cancers: evidence from international variation, time trends, and risk factor studies. , 2004, Toxicology and applied pharmacology.

[20]  H. Comber,et al.  Childhood cancer in Ireland: a population-based study , 2007, Archives of Disease in Childhood.

[21]  R. Swaminathan,et al.  Childhood cancers in Chennai, India, 1990–2001: Incidence and survival , 2008, International journal of cancer.

[22]  Kimberly J. Johnson,et al.  Parental and infant characteristics and childhood leukemia in Minnesota , 2008, BMC pediatrics.

[23]  C. Mathers,et al.  Violence-related mortality in Iraq from 2002 to 2006. , 2008, The New England journal of medicine.

[24]  P. Lewis.  Violence-related mortality in Iraq from 2002 to 2006 , 2008 .

[25]  J. Mejía-Aranguré,et al.  Bmc Cancer , 2022 .

[26]  Case-control study of leukaemia and non-Hodgkin's lymphoma among children aged 0-4 years living in west Berkshire and north Hampshire health districts. , 1993, BMJ.

[27]  L. Kinlen.  High-contact paternal occupations, infection and childhood leukaemia: five studies of unusual population-mixing of adults. , 1997, British Journal of Cancer.

[28]  S. Greenland,et al.  Socioeconomic status and childhood leukaemia: a review. , 2006, International journal of epidemiology.

[29]  H. Adami,et al.  Prenatal and neonatal risk factors for childhood lymphatic leukemia. , 1995, Journal of the National Cancer Institute.

[30]  Yuri Quintana,et al.  Childhood cancer epidemiology in low‐income countries , 2008, Cancer.