Emerging imaging techniques.

This article reviews recent developments in selected imaging technologies focused on the cardiovascular system. The techniques covered are: ultrasound biomicroscopy (UBM), microSPECT, microPET, near infrared imaging, and quantum dots. For each technique, the basic physical principles are explained and recent example applications demonstrated.

[1]  W. Webb,et al.  Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo , 2003, Science.

[2]  J. Mountz,et al.  Molecular imaging: New applications for biochemistry , 2002, Journal of cellular biochemistry. Supplement.

[3]  E. Ritman Micro-computed tomography-current status and developments. , 2004, Annual review of biomedical engineering.

[4]  J. Jaiswal,et al.  Potentials and pitfalls of fluorescent quantum dots for biological imaging. , 2004, Trends in cell biology.

[5]  D A Benaron,et al.  Imaging transgenic animals. , 1999, Annual review of biomedical engineering.

[6]  F. Foster Transducer materials and probe construction. , 2000, Ultrasound in medicine & biology.

[7]  Donald W. Wilson,et al.  Quantitative analysis of acute myocardial infarct in rat hearts with ischemia-reperfusion using a high-resolution stationary SPECT system. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[8]  Alessandro Torricelli,et al.  Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near-infrared spectroscopy , 2004, Physics in medicine and biology.

[9]  Mark Hewko,et al.  Regional variations in myocardial tissue oxygenation mapped by near-infrared spectroscopic imaging. , 2002, Journal of molecular and cellular cardiology.

[10]  David M. Auslander,et al.  Control and dynamic systems , 1970 .

[11]  T. Balla,et al.  Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic , 2001, The Journal of cell biology.

[12]  L W Hedlund,et al.  Magnetic Resonance Microscopy in Basic Studies of Brain Structure and Function a , b , 1997, Annals of the New York Academy of Sciences.

[13]  Donald W. Wilson,et al.  High-resolution imaging with (99m)Tc-glucarate for assessing myocardial injury in rat heart models exposed to different durations of ischemia with reperfusion. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[14]  S. Gambhir,et al.  Molecular imaging in living subjects: seeing fundamental biological processes in a new light. , 2003, Genes & development.

[15]  R. Leahy,et al.  High-resolution 3D Bayesian image reconstruction using the microPET small-animal scanner. , 1998, Physics in medicine and biology.

[16]  T. Nägele,et al.  Molecular imaging: Bridging the gap between neuroradiology and neurohistology. , 2004, Histology and histopathology.

[17]  P. Yock,et al.  Intravascular ultrasound: novel pathophysiological insights and current clinical applications. , 2001, Circulation.

[18]  Sanjiv S Gambhir,et al.  Positron Emission Tomography Imaging of Cardiac Reporter Gene Expression in Living Rats , 2002, Circulation.

[19]  Hedi Mattoussi,et al.  Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy , 2004, Nature Medicine.

[20]  M. Phelps,et al.  PET: the merging of biology and imaging into molecular imaging. , 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[21]  K. Chien,et al.  Genes and physiology: molecular physiology in genetically engineered animals. , 1996, The Journal of clinical investigation.

[22]  F Stuart Foster,et al.  In vivo imaging of embryonic development in the mouse eye by ultrasound biomicroscopy. , 2003, Investigative ophthalmology & visual science.

[23]  C. Pavlin,et al.  High frequency ultrasound. , 1995, The British journal of ophthalmology.

[24]  David W Townsend,et al.  PET/CT today and tomorrow. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[25]  Elazer R Edelman,et al.  Tissue Engineering Therapy for Cardiovascular Disease , 2003, Circulation research.

[26]  Sanjiv S. Gambhir,et al.  Small Animal Imaging Center Design: The Facility at the UCLA Crump Institute for Molecular Imaging , 2005, Molecular Imaging and Biology.

[27]  Sanjiv S Gambhir,et al.  Positron-Emission Tomography Reporter Gene Expression Imaging in Rat Myocardium , 2003, Circulation.

[28]  M. Bruchez,et al.  Lighting up cells with quantum dots. , 2003, BioTechniques.

[29]  F. Foster,et al.  Comprehensive transthoracic cardiac imaging in mice using ultrasound biomicroscopy with anatomical confirmation by magnetic resonance imaging. , 2004, Physiological genomics.

[30]  S. Gambhir Molecular imaging of cancer with positron emission tomography , 2002, Nature Reviews Cancer.

[31]  Hong Wang,et al.  Detection of tumor marker CA125 in ovarian carcinoma using quantum dots. , 2004, Acta biochimica et biophysica Sinica.

[32]  D. Taggart,et al.  Preliminary experience with a novel intraoperative fluorescence imaging technique to evaluate the patency of bypass grafts in total arterial revascularization. , 2003, The Annals of thoracic surgery.

[33]  K. Hoffmann,et al.  Ultrasound in Dermatology , 1988 .

[34]  J. Frangioni In vivo near-infrared fluorescence imaging. , 2003, Current opinion in chemical biology.

[35]  S. Nissen,et al.  Application of intravascular ultrasound to characterize coronary artery disease and assess the progression or regression of atherosclerosis. , 2002, The American journal of cardiology.

[36]  R. Leahy,et al.  Optimization and performance evaluation of the microPET II scanner for in vivo small-animal imaging , 2004, Physics in medicine and biology.

[37]  M. Black,et al.  A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[38]  H. Atkins,et al.  Pinhole SPECT: an approach to in vivo high resolution SPECT imaging in small laboratory animals. , 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[39]  Robert E. Lenkinski,et al.  In vivo near-infrared fluorescence imaging of osteoblastic activity , 2001, Nature Biotechnology.

[40]  Byron Ballou,et al.  Noninvasive imaging of quantum dots in mice. , 2004, Bioconjugate chemistry.

[41]  Vincent Noireaux,et al.  In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles , 2002, Science.

[42]  Arion F. Chatziioannou,et al.  Molecular imaging of small animals with dedicated PET tomographs , 2001, European Journal of Nuclear Medicine and Molecular Imaging.

[43]  T. Mihaljevic,et al.  Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping , 2004, Nature Biotechnology.

[44]  Simon R. Cherry,et al.  Comparison of 3-D maximum a posteriori and filtered backprojection algorithms for high-resolution animal imaging with microPET , 2000, IEEE Transactions on Medical Imaging.

[45]  S. Cherry,et al.  MicroPET II: design, development and initial performance of an improved microPET scanner for small-animal imaging. , 2003, Physics in medicine and biology.

[46]  S R Cherry,et al.  Detector development for microPET II: a 1 microl resolution PET scanner for small animal imaging. , 2001, Physics in medicine and biology.

[47]  W. Vaalburg,et al.  Positron emission tomography: measurement of transgene expression. , 2002, Methods.

[48]  G. Jemec,et al.  Ultrasound in dermatology. Part I. High frequency ultrasound. , 2000, European journal of dermatology : EJD.

[49]  D. Weber,et al.  Pinhole SPECT: ultra-high resolution imaging for small animal studies. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[50]  Jonathan R. Lindner,et al.  Microbubbles in medical imaging: current applications and future directions , 2004, Nature Reviews Drug Discovery.

[51]  V. Chernomordik,et al.  Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots1 , 2005 .

[52]  Wei Chen,et al.  Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots. , 2005, Academic radiology.

[53]  F. Foster,et al.  Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndrome. , 2005, American journal of physiology. Heart and circulatory physiology.

[54]  Jonathon Bishop,et al.  Magnetic resonance imaging for detection and analysis of mouse phenotypes , 2005, NMR in biomedicine.

[55]  D. Weber,et al.  Ultra-high-resolution imaging of small animals: Implications for preclinical and research studies , 1999, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[56]  W.P. Klein,et al.  FASTSPECT: electrical and mechanical design of a high-resolution dynamic SPECT imager , 1995, 1995 IEEE Nuclear Science Symposium and Medical Imaging Conference Record.

[57]  J. Frangioni,et al.  Functional Near-Infrared Imaging for Cardiac Surgery and Targeted Gene Therapy , 2002 .

[58]  M. Brezinski,et al.  Characterizing arterial plaque with optical coherence tomography , 2002, Current opinion in cardiology.

[59]  L. Hedlund,et al.  Morphologic phenotyping with MR microscopy: the visible mouse. , 2002, Radiology.

[60]  N. Satyamurthy,et al.  Quantitative imaging of gene induction in living animals , 2001, Gene Therapy.

[61]  William E. Lorensen,et al.  CATFEM - Computer-Assisted Tomography and Finite Element Modeling , 1991 .

[62]  Yong Taik Lim,et al.  Selection of Quantum Dot Wavelengths for Biomedical Assays and Imaging , 2003, Molecular imaging.

[63]  K. Chien,et al.  Physiological assessment of complex cardiac phenotypes in genetically engineered mice. , 1997, The American journal of physiology.

[64]  Vasilis Ntziachristos,et al.  Shedding light onto live molecular targets , 2003, Nature Medicine.

[65]  John V Frangioni,et al.  Functional Near-Infrared Fluorescence Imaging for Cardiac Surgery and Targeted Gene Therapy , 2002, Molecular imaging.

[66]  Paul Schoenhagen,et al.  Understanding coronary artery disease: tomographic imaging with intravascular ultrasound , 2002, Heart.