Visualizing breast cancer using the Twente photoacoustic mammoscope: what do we learn from twelve new patient measurements?

We acquired images of breast malignancies using the Twente photoacoustic mammoscope (PAM), to obtain more information about the clinical feasibility and limitations of photoacoustic mammography. Results were compared with conventional imaging and histopathology. Ten technically acceptable measurements on patients with malignancies and two measurements on patients with cysts were performed. In the reconstructed volumes of all ten malignant lesions, a confined region with high contrast with respect to the background could be seen. In all malignant cases, the PA contrast of the abnormality was higher than the contrast on x-ray mammography. The PA contrast appeared to be independent of the mammographically estimated breast density and was absent in the case of cysts. Technological improvements to the instrument and further studies on less suspicious lesions are planned to further investigate the potential of PAM.

[1]  H. Dehghani,et al.  Diffuse optical imaging , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[2]  P. V. van Deventer.  The blood supply to the nipple-areola complex of the human mammary gland. , 2004, Aesthetic plastic surgery.

[3]  M. Huang,et al.  Utilizing optical tomography with ultrasound localization to image heterogeneous hemoglobin distribution in large breast cancers. , 2005, Neoplasia.

[4]  Da Xing,et al.  Noninvasive photoacoustic imaging of the developing vasculature during early tumor growth , 2008, Physics in medicine and biology.

[5]  Yuan Xu,et al.  Exact frequency-domain reconstruction for thermoacoustic tomography. I. Planar geometry , 2002, IEEE Transactions on Medical Imaging.

[6]  C. Kuhl.  The current status of breast MR imaging. Part I. Choice of technique, image interpretation, diagnostic accuracy, and transfer to clinical practice. , 2007, Radiology.

[7]  O. Sarica,et al.  Evaluation of nipple-areola complex with ultrasonography and magnetic resonance imaging. , 2010, Journal of computer assisted tomography.

[8]  Wiendelt Steenbergen,et al.  The Twente Photoacoustic Mammoscope: system overview and performance , 2005, Physics in medicine and biology.

[9]  L. Benjamin,et al.  Angiogenesis: Tumorigenesis and the angiogenic switch , 2003, Nature Reviews Cancer.

[10]  Zhixing Xie,et al.  Photoacoustic imaging for deep targets in the breast using a multichannel 2D array transducer , 2011, BiOS.

[11]  M. Hall-Craggs,et al.  Breast MR and the appearance of the normal and abnormal nipple. , 1997, Clinical radiology.

[12]  Sandra K. Soho,et al.  Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes. , 2004, Journal of biomedical optics.

[13]  S. Emelianov,et al.  Photoacoustic imaging in cancer detection, diagnosis, and treatment guidance. , 2011, Trends in biotechnology.

[14]  T. Uematsu,et al.  Comparison of magnetic resonance imaging, multidetector row computed tomography, ultrasonography, and mammography for tumor extension of breast cancer , 2008, Breast Cancer Research and Treatment.

[15]  V. Ntziachristos,et al.  Model-based optoacoustic inversions with incomplete projection data. , 2011, Medical physics.

[16]  Robert C Brasch,et al.  Imaging of tumor angiogenesis: current approaches and future prospects. , 2006, Current pharmaceutical design.

[17]  B. Pogue,et al.  Near-infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities , 2003 .

[18]  S. Ciatto,et al.  Categorizing breast mammographic density: intra- and interobserver reproducibility of BI-RADS density categories. , 2005, Breast.

[19]  Rajesh Sehgal,et al.  Prevention of Breast Cancer (Part I): Epidemiology, Risk Factors, and Risk Assessment Tools , 2010, Cancer investigation.

[20]  A. Oraevsky,et al.  Laser optoacoustic imaging system for detection of breast cancer. , 2009, Journal of biomedical optics.

[21]  Wiendelt Steenbergen,et al.  Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms. , 2004, Journal of biomedical optics.

[22]  Lihong V Wang,et al.  Universal back-projection algorithm for photoacoustic computed tomography , 2005, SPIE BiOS.

[23]  R Cubeddu,et al.  Determination of visible near-IR absorption coefficients of mammalian fat using time- and spatially resolved diffuse reflectance and transmission spectroscopy. , 2005, Journal of biomedical optics.

[24]  V. Ntziachristos,et al.  Molecular imaging by means of multispectral optoacoustic tomography (MSOT). , 2010, Chemical reviews.

[25]  Manojit Pramanik,et al.  Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography. , 2008, Medical physics.

[26]  B. Tromberg,et al.  In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy. , 2006, Journal of biomedical optics.

[27]  F. M. van den Engh,et al.  Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics. , 2007, Optics express.

[28]  Sergio Fantini,et al.  Near-Infrared Optical Mammography for Breast Cancer Detection with Intrinsic Contrast , 2011, Annals of Biomedical Engineering.

[29]  P. Choyke,et al.  Imaging of angiogenesis: from microscope to clinic , 2003, Nature Medicine.

[30]  Paola Taroni,et al.  Diffuse optical spectroscopy of breast tissue extended to 1100 nm. , 2009, Journal of biomedical optics.

[31]  Rebecca S Lewis,et al.  Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer. , 2004, Radiology.

[32]  Qiang Wang,et al.  Quantitative photoacoustic tomography: recovery of optical absorption coefficient maps of heterogeneous media , 2007, SPIE BiOS.

[33]  Rami Nachabé,et al.  Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods. , 2011, Journal of biomedical optics.

[34]  Robert A Kruger,et al.  Photoacoustic angiography of the breast. , 2010, Medical physics.

[35]  Alessandro Torricelli,et al.  Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification. , 2009, Optics express.

[36]  Lihong V Wang,et al.  Photoacoustic tomography and sensing in biomedicine , 2009, Physics in medicine and biology.

[37]  Alexander A Karabutov,et al.  Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics. , 2007, Applied optics.

[38]  Wenfeng Xia,et al.  Photoacoustic Imaging of the Breast Using the Twente Photoacoustic Mammoscope: Present Status and Future Perspectives , 2010, IEEE Journal of Selected Topics in Quantum Electronics.

[39]  Junjie Yao,et al.  Photoacoustic tomography: fundamentals, advances and prospects. , 2011, Contrast media & molecular imaging.

[40]  Petrus V. Deventer,et al.  The Blood Supply to the Nipple-Areola Complex of the Human Mammary Gland , 2004 .

[41]  Alessandro Torricelli,et al.  Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy. , 2010, Journal of biomedical optics.

[42]  P. Beard.  Biomedical photoacoustic imaging , 2011, Interface Focus.

[43]  Srirang Manohar,et al.  Imaging of tumor vasculature using Twente photoacoustic systems , 2009, Journal of biophotonics.

[44]  Bernhard Brendel,et al.  Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging , 2009, European Radiology.

[45]  N. Jagannathan.  Breast tissue characterization by in vivo Magnetic Resonance Spectroscopy (MRS) , 2011 .

[46]  B. Tromberg,et al.  Spectroscopy enhances the information content of optical mammography. , 2002, Journal of biomedical optics.

[47]  Ivan Pelivanov,et al.  Optoacoustic tomography utilizing focused transducers: The resolution study , 2008 .

[48]  E. Cronin,et al.  Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis. , 2010, Radiology.

[49]  Simon R Arridge,et al.  Two-dimensional quantitative photoacoustic image reconstruction of absorption distributions in scattering media by use of a simple iterative method. , 2006, Applied optics.

[50]  N. Jagannathan.  Breast tissue characterization byin vivoMagnetic Resonance Spectroscopy (MRS) , 2011 .

[51]  T G van Leeuwen,et al.  Imaging Tumor Vascularization for Detection and Diagnosis of Breast Cancer , 2011, Technology in cancer research & treatment.

[52]  Yuan Xu,et al.  Effects of acoustic heterogeneity in breast thermoacoustic tomography , 2003, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[53]  E. Miller,et al.  Combined optical and X-ray tomosynthesis breast imaging. , 2011, Radiology.

[54]  Proton MR spectroscopy in normal breasts between pre- and postmenopausal women: a preliminary study. , 2008, AJR. American journal of roentgenology.

[55]  G. Yancopoulos,et al.  New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF , 1999, Oncogene.