Leucovorin as a prodrug.
暂无分享,去创建一个
[1] J. Doroshow,et al. Pharmacokinetics and toxicity of continuous infusion (6S)-folinic acid and bolus 5-fluorouracil in patients with advanced cancer. , 1992, Cancer research.
[2] J. C. Schmitz,et al. Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously. , 1991, Journal of the National Cancer Institute.
[3] D. Priest,et al. Human red blood cell-mediated metabolism of leucovorin [(R,S)5-formyltetrahydrofolate]. , 1991, Archives of biochemistry and biophysics.
[4] R. Schilsky,et al. Clinical pharmacokinetics of high-dose leucovorin calcium after intravenous and oral administration. , 1990, Journal of the National Cancer Institute.
[5] P. Houghton,et al. Relationship between dose rate of [6RS]Leucovorin administration, plasma concentrations of reduced folates, and pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon adenocarcinoma xenografts. , 1990, Cancer research.
[6] J. Zittoun,et al. Pharmacokinetics of (-)-folinic acid after oral and intravenous administration of the racemate. , 1989, British journal of clinical pharmacology.
[7] R. Ferone,et al. Clinical experience with leucovorin and 5‐fluorouracil , 1989, Cancer.
[8] D. Adelstein,et al. Efficacy of high‐dose oral leucovorin and 5‐fluorouracil in advanced colorectal carcinoma. Plasma and tissue pharmacokinetics , 1989, Cancer.
[9] P. Houghton,et al. Comparison of the conversion of 5-formyltetrahydrofolate and 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon tumors. , 1989, Cancer communications.
[10] N. Petrelli,et al. Plasma and tumor tissue pharmacology of high-dose intravenous leucovorin calcium in combination with fluorouracil in patients with advanced colorectal carcinoma. , 1988, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[11] D. Santi,et al. Cloning, sequencing, and expression of the Lactobacillus casei thymidylate synthase gene. , 1988, DNA.
[12] J. Bertino,et al. Effects of 5-methyltetrahydrofolate on the activity of fluoropyrimidines against human leukemia (CCRF-CEM) cells. , 1987, Biochemical pharmacology.
[13] R. Mackenzie,et al. Human liver methenyltetrahydrofolate synthetase: improved purification and increased affinity for folate polyglutamate substrates. , 1987, Biochimica et biophysica acta.
[14] Stokstad El,et al. Absorption kinetics of orally administered leucovorin calcium. , 1987, NCI monographs : a publication of the National Cancer Institute.
[15] D. Priest,et al. Tissue folate polyglutamate chain length determination by electrophoresis as thymidylate synthase-fluorodeoxyuridylate ternary complexes. , 1986, Methods in enzymology.
[16] R. Matthews. Methylenetetrahydrofolate reductase from pig liver. , 1986, Methods in enzymology.
[17] W. T. Wynn,et al. Pharmacokinetics of the diastereoisomers of leucovorin after intravenous and oral administration to normal subjects. , 1984, Cancer research.
[18] S. Hopkins,et al. 5,10-Methenyltetrahydrofolate synthetase. Purification and properties of the enzyme from rabbit liver. , 1984, The Journal of biological chemistry.
[19] S. Benkovic,et al. Folates and pterins , 1984 .
[20] P. Houghton,et al. The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts. , 1982, European journal of cancer & clinical oncology.
[21] J. Laskin,et al. Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil. , 1981, Cancer research.
[22] K. Danenberg,et al. Effect of 5, 10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism. , 1978, Biochemistry.
[23] D. Santi,et al. Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate. , 1978, Proceedings of the National Academy of Sciences of the United States of America.
[24] B. Cooper,et al. Intestinal Conversion of Folinic Acid to 5‐Methyltetrahydrofolate in Man , 1972, British journal of haematology.
[25] F. M. Huennekens,et al. Thymidylate synthetase from amethopterin-resistant Lactobacillus casei. , 1971, Biochemistry.
[26] F. M. Huennekens,et al. [50] N10-formyltetrahydrofolic deacylase: N10-formyltetrahydrofolate + H2O → formate + tetrahydrofolate , 1963 .