The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk
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[1] Y. Yazaki,et al. Antisense Repression of Proto-oncogene c-Cbl Enhances Activation of the JAK-STAT Pathway but Not the Ras Pathway in Epidermal Growth Factor Receptor Signaling* , 1997, The Journal of Biological Chemistry.
[2] J. Penninger,et al. cbl-3: a new mammalian cbl family protein , 1999, Oncogene.
[3] S. Corey,et al. Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF , 2000, Oncogene.
[4] Y. Yazaki,et al. The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells (*) , 1995, The Journal of Biological Chemistry.
[5] S. K. Shore,et al. Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts , 1999, Oncogene.
[6] W. Birchmeier,et al. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis , 1996, Nature.
[7] H. Band,et al. Molecules in focus: The c-Cbl oncoprotein , 1998 .
[8] W. Birchmeier,et al. Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[9] D. Bowtell,et al. The Cbl protooncoprotein stimulates CSF‐1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation , 1999, The EMBO journal.
[10] B. Druker,et al. The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[11] G. V. Vande Woude,et al. Met-HGF/SF: tumorigenesis, invasion and metastasis. , 2007, Ciba Foundation symposium.
[12] A. Bardelli,et al. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway , 1998, Nature.
[13] A. Bardelli,et al. Specific Uncoupling of GRB2 from the Met Receptor , 1996, The Journal of Biological Chemistry.
[14] Sakae Tanaka,et al. c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption , 1996, Nature.
[15] S. Shoelson,et al. The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120 , 1995, The Journal of Biological Chemistry.
[16] A. Godwin,et al. A Grb2-associated docking protein in EGF- and insulin-receptor signalling , 1996, Nature.
[17] G. G. Stokes. "J." , 1890, The New Yale Book of Quotations.
[18] T. Hirano,et al. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. , 1999, Blood.
[19] Francesco Pagano,et al. Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours , 1998, Oncogene.
[20] C. Cooper,et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line , 1984, Nature.
[21] M. Fiscella,et al. Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor , 1998, Oncogene.
[22] C. Cooper,et al. Mechanism of met oncogene activation , 1986, Cell.
[23] R. Baron,et al. Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7* , 1999, The Journal of Biological Chemistry.
[24] M. Matsuda,et al. Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells , 1993, Molecular and cellular biology.
[25] G. Rodrigues,et al. Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase , 1993, Molecular and cellular biology.
[26] A. Bardelli,et al. Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential , 1997, Oncogene.
[27] W. Langdon,et al. Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. , 1994, The EMBO journal.
[28] M. Shibuya,et al. Two species of human CRK cDNA encode proteins with distinct biological activities , 1992, Molecular and cellular biology.
[29] M. Nau,et al. cbl-b inhibits epidermal growth factor receptor signaling , 1999, Oncogene.
[30] M. Matsuda,et al. CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells , 1994, Molecular and cellular biology.
[31] Y. Yarden,et al. The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor* , 1999, The Journal of Biological Chemistry.
[32] M. Tremblay,et al. Association of the Multisubstrate Docking Protein Gab1 with the Hepatocyte Growth Factor Receptor Requires a Functional Grb2 Binding Site Involving Tyrosine 1356* , 1997, The Journal of Biological Chemistry.
[33] M. Czech,et al. Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells , 1995, Molecular and cellular biology.
[34] W. Langdon,et al. Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl , 1997, Oncogene.
[35] L. Schmidt,et al. Activating mutations for the met tyrosine kinase receptor in human cancer. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[36] S. Shoelson,et al. Stimulation through the T Cell Receptor Induces Cbl Association with Crk Proteins and the Guanine Nucleotide Exchange Protein C3G (*) , 1996, The Journal of Biological Chemistry.
[37] A. Bardelli,et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family , 1994, Cell.
[38] H. Band,et al. The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction. , 1997, Critical reviews in oncogenesis.
[39] S. Ōmura,et al. Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway , 1997, Molecular and cellular biology.
[40] M. E. Cook,et al. Regulation of β1-integrin-mediated cell adhesion by the CbI adaptor protein , 1998, Current Biology.
[41] A Ciechanover,et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. , 1999, Molecular cell.
[42] W. Marston Linehan,et al. Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas , 1998, Nature Genetics.
[43] Y. Yazaki,et al. c-Cbl is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3'-kinase pathway. , 1998, Blood.
[44] E. Ruoslahti,et al. Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases , 1996, Molecular and cellular biology.
[45] Keigo Nishida,et al. Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase , 1998, Molecular and Cellular Biology.
[46] M. Matsuda,et al. Emerging components of the Crk oncogene product: the first identified adaptor protein. , 1996, Cellular signalling.
[47] S. Feller,et al. Physiological signals and oncogenesis mediated through Crk family adapter proteins , 1998, Journal of cellular physiology.
[48] K. Vuori,et al. The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[49] W. Birchmeier,et al. Signaling of Hepatocyte Growth Factor/Scatter Factor (HGF) to the Small GTPase Rap1 via the Large Docking Protein Gab1 and the Adapter Protein CRKL* , 2000, The Journal of Biological Chemistry.
[50] Z. Kam,et al. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. , 1998, Genes & development.
[51] K. Vuori,et al. CAS/Crk Coupling Serves as a “Molecular Switch” for Induction of Cell Migration , 1998, The Journal of cell biology.
[52] B. Mayer,et al. Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins , 1995, Molecular and cellular biology.
[53] Aaron Ciechanover,et al. The ubiquitin–proteasome pathway: on protein death and cell life , 1998, The EMBO journal.
[54] C. Lowell,et al. A β1 integrin signaling pathway involving Src‐family kinases, Cbl and PI‐3 kinase is required for macrophage spreading and migration , 1998, The EMBO journal.
[55] J. Schlessinger,et al. Activation of the JNK pathway is essential for transformation by the Met oncogene , 1997, The EMBO journal.
[56] M. Barbacid,et al. Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation , 1997, Oncogene.
[57] D. Kamikura,et al. Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1* , 1997, The Journal of Biological Chemistry.
[58] K. Vuori,et al. Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 – Crk signaling complex formation , 1999, Oncogene.
[59] T. Hunter,et al. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. , 1999, Science.
[60] A. Wong,et al. Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. , 1997, Proceedings of the National Academy of Sciences of the United States of America.