Brief report Bone marrow precursor of extranodal T-cell lymphoma

The development of extranodal lymphomas is thought to be initiated by the transformation event in peripheral or-gans. Lymphomatoid papulosis (LyP) is a low-grade cutaneous lymphoma and may progress into the cutaneous anaplastic lymphoma. We identified 2 patients who 3 and 4 years before the development of LyP were treated for an unrelated malig-nancy (Burkitt lymphoma and small-cell B-cell lymphoma). We analyzed the T-cell receptor (TCR) gene rearrangement pattern in their skin, blood, and bone marrow, including the archival bone marrow sampled years before the development of clinically evident LyP. In all samples we detectedtheuniquemonoclonalTCRrear-rangements. This observation suggests that the initial malignant transformation in LyP occurred in bone marrow and not, as could be supposed, in the skin. (Blood. 2003;102:3797-3799)

[1]  J. V. Dongen,et al.  T cell receptor gamma gene rearrangements as targets for detection of minimal residual disease in acute lymphoblastic leukemia by real-time quantitative PCR analysis , 2002, Leukemia.

[2]  H. Stein,et al.  Single-cell analysis of CD30+ cells in lymphomatoid papulosis demonstrates a common clonal T-cell origin. , 2002, Blood.

[3]  M. Greaves,et al.  Chromosome translocations and covert leukemic clones are generated during normal fetal development , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[4]  J. Eshleman,et al.  Transmission of a T-cell lymphoma by allogeneic bone marrow transplantation. , 2001, The New England journal of medicine.

[5]  P. Batstone,et al.  Borrelia burgdorferi‐associated cutaneous marginal zone lymphoma: a clinicopathological study of two cases illustrating the temporal progression of B. burgdorferi‐associated B‐cell proliferation in the skin , 2000, Histopathology.

[6]  C. V. D. Schoot,et al.  Application of germline IGH probes in real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia , 2000, Leukemia.

[7]  K. Schmiegelow,et al.  Competitive PCR for quantification of minimal residual disease in acute lymphoblastic leukaemia. , 2000, Journal of immunological methods.

[8]  C. Hsieh,et al.  Increased risk of lymphoid and nonlymphoid malignancies in patients with lymphomatoid papulosis , 1999, Cancer.

[9]  M. Nap,et al.  Heat pretreatment increases resolution in DNA flow cytometry of paraffin-embedded tumor tissue. , 1999, Cytometry.

[10]  J. Dick,et al.  A newly discovered class of human hematopoietic cells with SCID-repopulating activity , 1998, Nature Medicine.

[11]  J. Dick,et al.  Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell , 1997, Nature Medicine.

[12]  A. Chott,et al.  The dominant T cell clone is present in multiple regressing skin lesions and associated T cell lymphomas of patients with lymphomatoid papulosis. , 1996, The Journal of investigative dermatology.

[13]  R. Warnke,et al.  Helicobacter pylori infection and gastric lymphoma. , 1994, The New England journal of medicine.

[14]  R. Willemze,et al.  The prognosis of patients with lymphomatoid papulosis associated with malignant lymphomas , 1992, The British journal of dermatology.

[15]  C. Morton,et al.  Hodgkin's disease, lymphomatoid papulosis, and cutaneous T-cell lymphoma derived from a common T-cell clone. , 1992, The New England journal of medicine.

[16]  A. de la Chapelle,et al.  Clonal chromosomal abnormalities showing multiple-cell-lineage involvement in acute myeloid leukemia. , 1988, The New England journal of medicine.

[17]  Shirley A. Miller,et al.  A simple salting out procedure for extracting DNA from human nucleated cells. , 1988, Nucleic acids research.

[18]  H. Levine,et al.  Uniform detection of immunoglobulin-gene rearrangement in benign lymphoepithelial lesions. , 1987, The New England journal of medicine.

[19]  R. Jaffe,et al.  Evidence that the malignant lymphoma of Sjögren's syndrome is a monoclonal B-cell neoplasm. , 1978, The New England journal of medicine.

[20]  J. Muche,et al.  A T-cell receptor gamma polymerase chain reaction assay using capillary electrophoresis for the diagnosis of cutaneous T-cell lymphomas. , 2002, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

[21]  K. Asadullah,et al.  Demonstration of frequent occurrence of clonal T cells in the peripheral blood of patients with primary cutaneous T-cell lymphoma. , 1997, Blood.

[22]  W. Hiddemann,et al.  Evidence for malignant transformation in acute myeloid leukemia at the level of early hematopoietic stem cells by cytogenetic analysis of CD34+ subpopulations. , 1995, Blood.