Visualization by Immune Electron Microscopy of a 27-nm Particle Associated with Acute Infectious Nonbacterial Gastroenteritis

A 27-nm particle was observed by immune electron microscopy in an infectious stool filtrate derived from an outbreak in Norwalk, Ohio, of acute infectious nonbacterial gastroenteritis. Both experimentally and naturally infected individuals developed serological evidence of infection; this along with other evidence suggested that the particle was the etiological agent of Norwalk gastroenteritis.

[1]  H. Fukumi,et al.  An indication as to identity between the infectious diarrhea in Japan and the afebrile infectious nonbacterial gastroenteritis by human volunteer experiments. , 1957, Japanese journal of medical science & biology.

[2]  I. Gordon.  The nonamebic nonbacillary diarrheal disorders. , 1955, The American journal of tropical medicine and hygiene.

[3]  W. S. Jordan,et al.  A study of illness in a group of Cleveland families. I. Plan of study and certain general observations. , 1953, American journal of hygiene.

[4]  J. Best,et al.  MORPHOLOGICAL CHARACTERISTICS OF RUBELLA VIRUS , 1967 .

[5]  D. Rubenstein,et al.  New antigen-antibody system in Australia-antigen-positive hepatitis. , 1971, Lancet.

[6]  N. Hadju.  A virus from epidemic vomiting disease. , 1972, British medical journal.

[7]  R. Chanock,et al.  Acute Infectious Nonbacterial Gastroenteritis: Etiology and Pathogenesis , 1972 .

[8]  J. H. Hodges,et al.  The Cause of Epidemic Diarrhea, Nausea and Vomiting. (Viral Dysentery?) , 1945 .

[9]  A. P. Waterson,et al.  The Morphology of Virus-Antibody Interaction , 1969, Advances in Virus Research.

[10]  A. Kapikian,et al.  Immune Electron Microscopy of Rhinoviruses , 1972, Journal of virology.

[11]  William S. Jordan,et al.  Illness in the home : a study of 25,000 illnesses in a group of Cleveland families , 1964 .

[12]  G. Currie,et al.  Clinical laboratory studies in experimentally-induced epidemic nonbacterial gastroenteritis. , 1953, The Journal of laboratory and clinical medicine.

[13]  Y. Cossart,et al.  Virus-like particles in serum of patients with Australia-antigen-associated hepatitis. , 1970, Lancet.

[14]  J. Adler,et al.  Winter vomiting disease. , 1969, The Journal of infectious diseases.

[15]  R. Korns,et al.  TRANSMISSION OF EPIDEMIC GASTROENTERITIS TO HUMAN VOLUNTEERS BY ORAL ADMINISTRATION OF FECAL FILTRATES , 1947, The Journal of experimental medicine.

[16]  W. S. Jordan,et al.  A study of illness in a group of Cleveland families. XIII. Clinical description of acute nonbacterial gastroenteritis. , 1956, American journal of hygiene.

[17]  R. Chanock,et al.  Transmission of acute infectious nonbacterial gastroenteritis to volunteers by oral administration of stool filtrates. , 1971, The Journal of infectious diseases.

[18]  W. S. Jordan,et al.  A STUDY OF ILLNESS IN A GROUP OF CLEVELAND FAMILIES , 1953, The Journal of experimental medicine.

[19]  K. Kuretani,et al.  Studies on the Causative Agent of the Infectious Diarrhoea. Records of the Experiments on Human Volunteers. , 1948 .

[20]  R. Chanock,et al.  Biological Properties of Norwalk Agent of Acute Infectious Nonbacterial Gastroenteritis , 1972, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.