Dynamics of hydrophobic organic chemical bioconcentration in fish

A model is presented describing the kinetics of uptake and release of nonmetabolizing organic chemicals by fish from water. The model contains three parameters: a bioconcentration factor which is specific to the chemical (and can be characterized by the octanol/water partition coefficient and fish lipid content), a water-phase resistance term and a lipid-phase resistance term which are specific to the fish. These parameters can be estimated from uptake-clearance experiments. Part of the water-phase resistance term can be attributed to gill ventilation rate as estimated from gill uptake efficiencies and part is an “internal” resistance. Procedures are suggested for scaling these parameters to different fish sizes. The dependence of these resistances, and uptake and clearance rate constants, on chemical hydrophobicity is discussed and quantified.

[1]  S. Yalkowsky,et al.  Correlation and prediction of mass transport across membranes. I. Influence of alkyl chain length on flux-determining properties of barrier and diffusant. , 1972, Journal of pharmaceutical sciences.

[2]  G. Flynn,et al.  Drug absorption kinetics in goldfish. , 1973, Journal of pharmaceutical sciences.

[3]  S. Yalkowsky,et al.  Effects of alkyl chain length on biological activity: alkyl p-aminobenzoate-induced narcosis in goldfish. , 1974, Journal of pharmaceutical sciences.

[4]  G. Blau,et al.  Bioconcentration of 2,2′,4,4′-Tetrachlorobiphenyl in Rainbow Trout as Measured by an Accelerated Test , 1975 .

[5]  A. McKinnon,et al.  A Bioenergetics-Based Model for Pollutant Accumulation by Fish. Simulation of PCB and Methylmercury Residue Levels in Ottawa River Yellow Perch (Perca flavescens) , 1976 .

[6]  O. Hutzinger,et al.  Some thoughts on aqueous solubilities and partition coefficients of PCB, and the mathematical correlation between bioaccumulation and physico-chemical properties , 1978 .

[7]  W. Brock Neely,et al.  Estimating rate constants for the uptake and clearance of chemicals by fish , 1979 .

[8]  Gilman D. Veith,et al.  Measuring and Estimating the Bioconcentration Factor of Chemicals in Fish , 1979 .

[9]  H. Esser,et al.  Factors determining the bioaccumulation potential of pesticides in the individual compartments of aquatic food chains. , 1980, Ecotoxicology and environmental safety.

[10]  Kees van Leeuwen,et al.  Toxicokinetics in fish: Accumulation and elimination of six chlorobenzenes by guppies , 1980 .

[11]  W. A. Bruggeman,et al.  Accumulation and elimination kinetics of di-, tri- and tetra chlorobiphenyls by goldfish after dietary and aqueous exposure , 1981 .

[12]  D Mackay,et al.  Correlation of bioconcentration factors. , 1982, Environmental science & technology.

[13]  J. Hamelink,et al.  Alternative models for describing the bioconcentration of organics in fish , 1982 .

[14]  B. G. Oliver,et al.  Biological Half-lives of Polychlorinated Biphenyl (PCB) Congeners in Whole Fish and Muscle of Rainbow Trout (Salmo gairdneri) , 1983 .

[15]  J. McCarthy,et al.  Role of participate organic matter in decreasing accumulation of polynuclear aromatic hydrocarbons byDaphnia magna , 1983 .

[16]  D Mackay,et al.  Three-parameter equation describing the uptake of organic compounds by fish. , 1984, Environmental science & technology.

[17]  O. Hutzinger,et al.  Bioaccumulation of super‐lipophilic chemicals in fish , 1984 .

[18]  D. Muir,et al.  Bioconcentration of PCDDs by fish: Effects of molecular structure and water chemistry , 1985 .

[19]  Des Connell,et al.  Relationships between partition coefficient, uptake rate constant, clearance rate constant and time to equilibrium for bioaccumulation , 1985 .

[20]  P. Landrum,et al.  Predicting the bioavailability of organic xenobiotics to Pontoporeia hoyi in the presence of humic and fulvic materials and natural dissolved organic matter , 1985 .

[21]  G. Veith,et al.  Absorption dynamics of organic chemical transport across trout gills as related to octanol-water partition coefficient. , 1985, Toxicology and applied pharmacology.

[22]  Frank A. P. C. Gobas,et al.  Relationship between bioconcentration in fish and steric factors of hydrophobic chemicals , 1985 .

[23]  Frank A. P. C. Gobas,et al.  Bioconcentration of hydrophobic chemicals in fish: Relationship with membrane permeation , 1986 .