Feasibility of terahertz time-domain spectroscopy to detect tetracyclines hydrochloride in infant milk powder.

We report the use of terahertz time-domain spectroscopy (THz-TDS) to detect tetracyclines hydrochloride (TCsH) in infant milk powder for the first time. Four kinds of TCsH exhibited their unique spectral features in the region of 0.3-1.8 THz. The main spectral features of these TCsH were still detectable when mixed with infant milk powder with concentrations at 1%-50%, even in the ternary mixtures. The results from chemometrics analysis showed that qualitative and quantitative detection of TCsH in infant milk powder could be successfully achieved. The residual predictive deviation (RPD) values of all these TCsH models were all higher than 2, indicating these models were considered good and could be used in screening purposes. The RPD values of TCH, DTCH, and CTCH models were higher than 3, which were considered excellent for prediction purposes. These preliminary results indicated that THz-TDS combined with chemometrics analysis was suitable for detecting the presence of TCsH residues in a food matrix.

[1]  Ulrich J. Griesser,et al.  Qualitative and quantitative study of polymorphic forms in drug formulations by near infrared FT-Raman spectroscopy , 2003 .

[2]  John E Cunningham,et al.  Effect of molecular size and particle shape on the terahertz absorption of a homologous series of tetraalkylammonium salts. , 2013, Analytical chemistry.

[3]  S. Sivakesava,et al.  Rapid determination of tetracycline in milk by FT-MIR and FT-NIR spectroscopy. , 2002, Journal of dairy science.

[4]  J. Zhao,et al.  Multiresidue determination of tetracycline antibiotics in propolis by using HPLC-UV detection with ultrasonic-assisted extraction and two-step solid phase extraction , 2009 .

[5]  E. Stobberingh,et al.  Epidemiology of resistance to antibiotics. Links between animals and humans. , 2000, International journal of antimicrobial agents.

[6]  Isao Tomita,et al.  Quantitative measurements of amino acids by terahertz time-domain transmission spectroscopy. , 2006, Analytical chemistry.

[7]  Usefulness of parallel factor analysis to handle the matrix effect in the fluorescence determination of tetracycline in whey milk. , 2009, Analytica chimica acta.

[8]  E. Heilweil,et al.  Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz , 2000 .

[9]  Yuegang Zuo,et al.  Simultaneous determination of tetracycline, oxytetracycline, and 4-epitetracycline in milk by high-performance liquid chromatography , 2007 .

[10]  Susana Campuzano,et al.  Integrated disposable electrochemical immunosensors for the simultaneous determination of sulfonamide and tetracycline antibiotics residues in milk. , 2013, Biosensors & bioelectronics.

[11]  A. Marco Saitta,et al.  First-principles modeling of the infrared spectrum of kaolinite , 2001 .

[12]  H. Wu,et al.  Process analytical technology (PAT): effects of instrumental and compositional variables on terahertz spectral data quality to characterize pharmaceutical materials and tablets. , 2007, International journal of pharmaceutics.

[13]  Tadao Nagatsuma,et al.  24 Gbit/s data transmission in 300 GHz band for future terahertz communications , 2012 .

[14]  Ángel Maquieira,et al.  Fast screening methods to detect antibiotic residues in food samples , 2010 .

[15]  Yaochun Shen,et al.  Terahertz pulsed spectroscopy and imaging for pharmaceutical applications: a review. , 2011, International journal of pharmaceutics.

[16]  H. Nau,et al.  Residue analysis of tetracyclines and their metabolites in eggs and in the environment by HPLC coupled with a microbiological assay and tandem mass spectrometry. , 2003, Journal of agricultural and food chemistry.

[17]  D. Cozzolino,et al.  Prediction of phenolic compounds in red wine fermentations by visible and near infrared spectroscopy , 2004 .

[18]  Yuko Ito,et al.  Chromatographic analysis of tetracycline antibiotics in foods. , 2000, Journal of chromatography. A.

[19]  Willem Haasnoot,et al.  Label-free and multiplex detection of antibiotic residues in milk using imaging surface plasmon resonance-based immunosensor. , 2009, Analytical chemistry.

[20]  Li Jiusheng,et al.  Optical Parameters of Vegetable Oil Studied by Terahertz Time-Domain Spectroscopy , 2010, Applied spectroscopy.

[21]  Yibin Ying,et al.  The Detection of Agricultural Products and Food Using Terahertz Spectroscopy: A Review , 2013 .

[22]  Yolanda Picó,et al.  Determination of tetracyclines in multi-specie animal tissues by pressurized liquid extraction and liquid chromatography-tandem mass spectrometry , 2009 .

[23]  Li Wang,et al.  Alkanethiol-functionalized terahertz metamaterial as label-free, highly-sensitive and specific biosensor. , 2013, Biosensors & bioelectronics.

[24]  Prashanth C. Upadhya,et al.  Far-infrared vibrational modes of polycrystalline saccharides , 2004 .

[25]  Anastasios D. Koulouklidis,et al.  Detection of Harmful Residues in Honey Using Terahertz Time-Domain Spectroscopy , 2013, Applied spectroscopy.

[26]  Chennupati Jagadish,et al.  Electronic properties of GaAs, InAs and InP nanowires studied by terahertz spectroscopy , 2013, Nanotechnology.

[27]  Hoeil Chung,et al.  Impact of pellet thickness on quantitative terahertz spectroscopy of solid samples in a polyethylene matrix. , 2013, Analytical chemistry.

[28]  Albert Redo-Sanchez,et al.  Assessment of terahertz spectroscopy to detect antibiotic residues in food and feed matrices. , 2011, The Analyst.

[29]  Erika Rodriguez,et al.  An overview of sample preparation procedures for LC-MS multiclass antibiotic determination in environmental and food samples , 2009, Analytical and bioanalytical chemistry.

[30]  V. Wallace,et al.  Biomedical applications of terahertz technology , 2006 .

[31]  Pavel Matousek,et al.  Tetracycline and derivatives—assignment of IR and Raman spectra via DFT calculations , 2003 .

[32]  Gerard Downey,et al.  Detection and identification of bacteria in an isolated system with near-infrared spectroscopy and multivariate analysis. , 2008, Journal of agricultural and food chemistry.

[33]  D. Cozzolino,et al.  Feasibility study on the use of visible and near-infrared spectroscopy together with chemometrics to discriminate between commercial white wines of different varietal origins. , 2003, Journal of agricultural and food chemistry.

[34]  C. Hurburgh,et al.  Near-Infrared Reflectance Spectroscopy–Principal Components Regression Analyses of Soil Properties , 2001 .

[35]  B. Fischer,et al.  Dynamic range in terahertz time-domain transmission and reflection spectroscopy. , 2005, Optics letters.

[36]  Xicheng Zhang,et al.  Materials for terahertz science and technology , 2002, Nature materials.

[37]  D. Donoghue,et al.  Simultaneous determination of fluoroquinolones and tetracyclines in chicken muscle using HPLC with fluorescence detection. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.