Decreased high‐molecular‐weight adiponectin in gestational diabetes: implications for the pathophysiology of Type 2 diabetes

Aims  Low serum concentrations of the insulin‐sensitizing protein adiponectin predict the development of incident Type 2 diabetes (T2DM). It has recently emerged that the anti‐diabetic activity of adiponectin may be mediated by its high‐molecular‐weight (HMW) isoform, circulating levels of which are decreased in T2DM. The relevance of decreased HMW adiponectin to incident T2DM, however, has not been assessed. Since gestational diabetes (GDM) identifies a population of young women at high risk of future T2DM (i.e. representing an early stage in the natural history of the disease), we sought to determine if decreased HMW adiponectin is a feature of GDM.

[1]  M. Matsuda,et al.  Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. , 1999, Diabetes care.

[2]  S. Kihara,et al.  Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin , 2004, Circulation research.

[3]  C. Drevon,et al.  Adiponectin is reduced in gestational diabetes mellitus in normal weight women , 2004, Acta obstetricia et gynecologica Scandinavica.

[4]  W. Garvey,et al.  Adiponectin multimeric complexes and the metabolic syndrome trait cluster. , 2006, Diabetes.

[5]  Jonathan Krakoff,et al.  Adiponectin and development of type 2 diabetes in the Pima Indian population , 2002, The Lancet.

[6]  H. Boeing,et al.  Adiponectin and protection against type 2 diabetes mellitus , 2003, The Lancet.

[7]  H. Lodish,et al.  Role of Disulfide Bonds in Acrp30/Adiponectin Structure and Signaling Specificity , 2003, Journal of Biological Chemistry.

[8]  J. Kirwan,et al.  Clinically useful estimates of insulin sensitivity during pregnancy: validation studies in women with normal glucose tolerance and gestational diabetes mellitus. , 2001, Diabetes care.

[9]  B. Zinman,et al.  Reduced adiponectin concentration in women with gestational diabetes: a potential factor in progression to type 2 diabetes. , 2004, Diabetes care.

[10]  B. Zinman,et al.  Low Serum Levels of High–Molecular Weight Adiponectin in Indo-Asian Women During Pregnancy , 2006, Diabetes Care.

[11]  T Nakamura,et al.  Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[12]  M. Cnop,et al.  Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex , 2003, Diabetologia.

[13]  A. Pfeiffer,et al.  Changes of adiponectin oligomer composition by moderate weight reduction. , 2005, Diabetes.

[14]  M. Stumvoll,et al.  Oral glucose tolerance test indexes for insulin sensitivity and secretion based on various availabilities of sampling times. , 2001, Diabetes care.

[15]  D. Luthy,et al.  Plasma adiponectin concentrations in early pregnancy and subsequent risk of gestational diabetes mellitus. , 2003, The Journal of clinical endocrinology and metabolism.

[16]  B. Zinman,et al.  Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications , 2005, Diabetologia.

[17]  S. Fowler,et al.  Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. , 2002 .

[18]  B. Goldstein,et al.  Adiponectin: A novel adipokine linking adipocytes and vascular function. , 2004, The Journal of clinical endocrinology and metabolism.

[19]  A. Kautzky-Willer,et al.  Decreased plasma adiponectin concentrations in women with gestational diabetes mellitus. , 2004, American journal of obstetrics and gynecology.

[20]  M. Igarashi,et al.  Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study. , 2003, Diabetes care.

[21]  B. Zinman,et al.  C-reactive protein and gestational diabetes: the central role of maternal obesity. , 2003, The Journal of clinical endocrinology and metabolism.

[22]  S. Haffner,et al.  Plasma adiponectin is an independent predictor of type 2 diabetes in Asian indians. , 2003, Diabetes care.

[23]  L. Campbell,et al.  The metabolism of isoforms of human adiponectin: studies in human subjects and in experimental animals. , 2005, European journal of endocrinology.

[24]  T. Buchanan,et al.  Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women. , 2002, Diabetes.

[25]  K. Polonsky,et al.  C-Peptide as a Measure of the Secretion and Hepatic Extraction of Insulin: Pitfalls and Limitations , 1984, Diabetes.

[26]  John A Wagner,et al.  Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity* , 2004, Journal of Biological Chemistry.