Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
暂无分享,去创建一个
M. Ladomery | S. Harper | D. Bates | M. Saleem | J. Woolard | A. Churchill | D. Nowak | O. Konopatskaya | Elianna M Amin
[1] Maryam Hamdollah-Zadeh,et al. Recombinant human VEGF165b protein is an effective anti-cancer agent in mice. , 2008, European journal of cancer.
[2] S. Harper,et al. Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[3] S. Harper,et al. VEGF165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy , 2008, British Journal of Cancer.
[4] E. Kleinerman,et al. The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice , 2008, British Journal of Cancer.
[5] D. Bates,et al. Expression of VEGFxxxb, the inhibitory isoforms of VEGF, in malignant melanoma , 2007, British Journal of Cancer.
[6] F. Eitner,et al. Impaired glomerular maturation and lack of VEGF165b in Denys-Drash syndrome. , 2007, Journal of the American Society of Nephrology : JASN.
[7] Jung-Chun Lin,et al. Cell stress modulates the function of splicing regulatory protein RBM4 in translation control , 2007, Proceedings of the National Academy of Sciences.
[8] A. Bikfalvi,et al. Tumor angiogenesis , 2020, Advances in cancer research.
[9] J. Wood,et al. A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2 , 2006, Cellular and Molecular Life Sciences CMLS.
[10] Yan Qiu,et al. The endogenous anti-angiogenic family of splice variants of VEGF, VEGFxxxb, are down-regulated in pre-eclamptic placentae at term. , 2006, Clinical science.
[11] S. Harper,et al. VEGF165b, an endogenous C-terminal splice variant of VEGF, inhibits retinal neovascularization in mice. , 2006, Molecular vision.
[12] J. Venables. Unbalanced alternative splicing and its significance in cancer , 2006, BioEssays : news and reviews in molecular, cellular and developmental biology.
[13] A. Nash,et al. The biology of vascular endothelial growth factor-B (VEGF-B). , 2006, Pulmonary pharmacology & therapeutics.
[14] Leandro Quadrana,et al. Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT , 2005, Nature Structural &Molecular Biology.
[15] Christopher W. J. Smith. Alternative Splicing— When Two’s a Crowd , 2005, Cell.
[16] S. Harper,et al. Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor , 2005, Diabetologia.
[17] M. Rastaldi,et al. Sam68-like mammalian protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular endothelial growth factor. , 2005, Journal of the American Society of Nephrology : JASN.
[18] A. Kornblihtt,et al. Promoter usage and alternative splicing. , 2005, Current opinion in cell biology.
[19] F. Clark,et al. Understanding alternative splicing: towards a cellular code , 2005, Nature Reviews Molecular Cell Biology.
[20] K. Silina,et al. Alterations of pre‐mRNA splicing in cancer , 2005, Genes, chromosomes & cancer.
[21] K. Tsubota,et al. TGF-beta1, IL-1beta, and Th2 cytokines stimulate vascular endothelial growth factor production from conjunctival fibroblasts. , 2005, Experimental eye research.
[22] B. O’Malley,et al. Steroid Hormone Receptor Coactivation and Alternative RNA Splicing by U2AF65-Related Proteins CAPERα and CAPERβ , 2005 .
[23] B. O’Malley,et al. Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta. , 2005, Molecular cell.
[24] M. Rastaldi,et al. Sam 68-Like Mammalian Protein 2 , Identified by Digital Differential Display as Expressed by Podocytes , Is Induced in Proteinuria and Involved in Splice Site Selection of Vascular Endothelial Growth Factor , 2005 .
[25] E. Gragoudas,et al. Pegaptanib for neovascular age-related macular degeneration. , 2004, The New England journal of medicine.
[26] W. Jin,et al. Enhancer-Dependent Splicing of FGFR1 α-Exon Is Repressed by RNA Interference-Mediated Down-Regulation of SRp55 , 2004, Cancer Research.
[27] C. Lechuga,et al. TGF-beta1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK, PI3-kinase, AKT, and p70S6k. , 2004, American journal of physiology. Gastrointestinal and liver physiology.
[28] Marina Ziche,et al. VEGF165b, an Inhibitory Vascular Endothelial Growth Factor Splice Variant , 2004, Cancer Research.
[29] D. Helfman,et al. A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells. , 2004, Molecular biology of the cell.
[30] Hiroshi Yamamoto,et al. Possible participation of pICln in the regulation of angiogenesis through alternative splicing of vascular endothelial growth factor receptor mRNAs. , 2004, Endothelium : journal of endothelial cell research.
[31] J. Berlin,et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. , 2004, The New England journal of medicine.
[32] D. Gillatt,et al. Differentiated human podocytes endogenously express an inhibitory isoform of vascular endothelial growth factor (VEGF165b) mRNA and protein. , 2004, American journal of physiology. Renal physiology.
[33] G. Neufeld,et al. Similarities and differences between the vascular endothelial growth factor (VEGF) splice variants , 1996, Cancer and Metastasis Reviews.
[34] Seth M Steinberg,et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. , 2003, The New England journal of medicine.
[35] M. Mccarthy. Antiangiogenesis drug promising for metastatic colorectal cancer , 2003, The Lancet.
[36] M. Lai,et al. Differential effects of hyperphosphorylation on splicing factor SRp55. , 2003, The Biochemical journal.
[37] John I. Loewenstein,et al. Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: phase II study results. , 2003, Ophthalmology.
[38] F. Otsuka,et al. PDGF‐BB Induces MAP Kinase Phosphorylation and VEGF Expression in Neurofibroma‐Derived Cultured Cells from Patients with Neurofibromatosis 1 , 2002, The Journal of dermatology.
[39] D. Gillatt,et al. VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma. , 2002, Cancer research.
[40] A. Kornblihtt,et al. Alternative splicing: multiple control mechanisms and involvement in human disease. , 2002, Trends in genetics : TIG.
[41] M. O'hare,et al. A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. , 2002, Journal of the American Society of Nephrology : JASN.
[42] D. Gillatt,et al. VEGF 165 b , an Inhibitory Splice Variant of Vascular Endothelial Growth Factor , Is Down-Regulated in Renal Cell Carcinoma 1 , 2002 .
[43] M. Benito,et al. Activation of p38MAPK by TGF‐β in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death , 2001, FEBS letters.
[44] M. Dake,et al. Vascular endothelial growth factor enhances atherosclerotic plaque progression , 2001, Nature Medicine.
[45] Peter Carmeliet,et al. VEGF gene therapy: stimulating angiogenesis or angioma-genesis? , 2000, Nature Medicine.
[46] D. Charnock-Jones,et al. The effect of progestins on vascular endothelial growth factor, oestrogen receptor and progesterone receptor immunoreactivity and endothelial cell density in human endometrium. , 2000, Human reproduction.
[47] A. Krainer,et al. The Mkk3/6-p38–Signaling Cascade Alters the Subcellular Distribution of Hnrnp A1 and Modulates Alternative Splicing Regulation , 2000, The Journal of cell biology.
[48] G. Edelman,et al. Differential regulation by multiple promoters of the gene encoding the neuron-restrictive silencer factor. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[49] T. Pawson,et al. The Protein Kinase Clk/Sty Directly Modulates SR Protein Activity: Both Hyper- and Hypophosphorylation Inhibit Splicing , 1999, Molecular and Cellular Biology.
[50] A. Kornblihtt,et al. Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer. , 1999, Molecular cell.
[51] J. Manley,et al. Phosphorylated RNA polymerase II stimulates pre-mRNA splicing. , 1999, Genes & development.
[52] G. Neufeld,et al. Vascular endothelial growth factor (VEGF) and its receptors , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[53] J. Klekamp,et al. Vascular endothelial growth factor expression is decreased in rat lung following exposure to 24 or 48 hours of hyperoxia: implications for endothelial cell survival. , 1998, Chest.
[54] G. Siemeister,et al. Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression , 1997, Oncogene.
[55] B. Keyt,et al. Disulfide structure of the heparin binding domain in vascular endothelial growth factor: characterization of posttranslational modifications in VEGF. , 1997, Archives of biochemistry and biophysics.
[56] T. Maniatis,et al. Common themes in the function of transcription and splicing enhancers. , 1997, Current opinion in cell biology.
[57] Tom Misteli,et al. The dynamics of a pre-mRNA splicing factor in living cells , 1997, Nature.
[58] N. Ferrara,et al. The biology of vascular endothelial growth factor. , 1997, Endocrine reviews.
[59] K. Matsumoto,et al. Interleukin 10 and interleukin 13 synergize to inhibit vascular permeability factor release by peripheral blood mononuclear cells from patients with lipoid nephrosis. , 1997, Nephron.
[60] E. Haber,et al. Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells. , 1996, The Journal of clinical investigation.
[61] C. Patterson,et al. Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor I. , 1996, Endocrinology.
[62] S. Kondo,et al. Vascular endothelial growth factor is induced by long-term high glucose concentration and up-regulated by acute glucose deprivation in cultured bovine retinal pigmented epithelial cells. , 1996, Biochemical and biophysical research communications.
[63] R. Kerbel,et al. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. , 1995, Cancer research.
[64] D. Mukhopadhyay,et al. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation , 1995, Nature.
[65] C. Patterson,et al. Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1 in Rat Aortic Smooth Muscle Cells (*) , 1995, The Journal of Biological Chemistry.
[66] K. Alitalo,et al. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. , 1994, The Journal of biological chemistry.
[67] E. Keshet,et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis , 1992, Nature.
[68] J. Winer,et al. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. , 1991, Molecular endocrinology.
[69] J. Folkman,et al. Conditioned medium from mouse sarcoma 180 cells contains vascular endothelial growth factor. , 1990, Growth factors.
[70] P. Chomczyński,et al. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.