Synthesis of N,N′-Disulfonylamidines from Sulfonamides and Alkynes by a Two-Step, One-Pot Reaction with Nonafluorobutanesulfonyl Azide

Nonafluorobutanesulfonyl azide is an advantageous alternative to triflyl azide for the efficient synthesis of sulfonyl azides from sulfonamides in terms of its higher reactivity, lower cost, and non-hazardous nature. The reagent has proven its utility in a novel synthesis of N,N′-disulfonylamidines from available sulfonamides by a copper-catalyzed two-step, one-pot sequential process with added terminal alkynes.

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