论文信息 - Structural studies on minor components of saframycin group antibiotics saframycins F, G and H.

Structural studies on minor components of saframycin group antibiotics saframycins F, G and H.

Three minor components of saframycin group antibiotics, saframycins F, G and H were isolated and their structures were determined by comparison with the spectral data of UV, IR, and 1H and 13C NMR of already reported saframycins A and D. Saframycins F, G and H were 21-cyanosaframycin D, 14-hydroxysaframycin A and 25-dihydro-25-beta-ketopropyl-saframycin A, respectively.

[1] N. Saito,et al. Isolation and structural elucidation of new saframycins Y3, Yd-1, Yd-2, Ad-1, Y2b and Y2b-d. , 1986, The Journal of antibiotics.

[2] K. Yazawa,et al. Antitumor activity of new semisynthetic saframycin derivatives. , 1986, Japanese journal of cancer research : Gann.

[3] K. Yazawa,et al. Directed biosynthesis of new saframycin derivatives with resting cells of Streptomyces lavendulae , 1985, Antimicrobial Agents and Chemotherapy.

[4] S. Iwasaki,et al. Biosynthetic studies on saframycin A, a quinone antitumor antibiotic produced by Streptomyces lavendulae. , 1985, The Journal of biological chemistry.