Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.
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A. Sher | R. Flavell | M. Busslinger | B. Mccright | F. Radtke | D. Amsen | A. Antov | Dragana Jankovic | A. Souabni | T. Gridley | B. McCright
[1] S. Blacklow,et al. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. , 2007, Immunity.
[2] M. Nussenzweig,et al. CD8− DCs induce IL-12–independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS , 2007, The Journal of experimental medicine.
[3] R. D. Hatton,et al. IL-17 family cytokines and the expanding diversity of effector T cell lineages. , 2007, Annual review of immunology.
[4] T. Kinoshita,et al. XMam1, Xenopus Mastermind1, induces neural gene expression in a Notch-independent manner , 2006, Mechanisms of Development.
[5] S. Bray. Notch signalling: a simple pathway becomes complex , 2006, Nature Reviews Molecular Cell Biology.
[6] M. Kubo,et al. The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells. , 2006, Immunity.
[7] Thomas M. Schmitt,et al. Notch Signaling Requires GATA-2 to Inhibit Myelopoiesis from Embryonic Stem Cells and Primary Hemopoietic Progenitors1 , 2006, The Journal of Immunology.
[8] Bogdan Tanasa,et al. Regulation of Th2 differentiation and Il4 locus accessibility. , 2006, Annual review of immunology.
[9] Yuka Kanno,et al. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription , 2006, The Journal of experimental medicine.
[10] R. Bronson,et al. The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. , 2006, Genes & development.
[11] T. So,et al. Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[12] A. Freitas,et al. Notch signaling: distinct ligands induce specific signals during lymphocyte development and maturation. , 2006, Immunology letters.
[13] G. Sonenshein,et al. Notch1 augments NF‐κB activity by facilitating its nuclear retention , 2006 .
[14] B. Mccright,et al. Generation of new Notch2 mutant alleles , 2006, Genesis.
[15] M. Busslinger,et al. Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney , 2006, Development.
[16] G. Sonenshein,et al. Notch1 augments NF-kappaB activity by facilitating its nuclear retention. , 2006, The EMBO journal.
[17] Yu Wang,et al. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand , 2005, The Journal of experimental medicine.
[18] W. Pear,et al. Notch signaling is an important regulator of type 2 immunity , 2005, The Journal of experimental medicine.
[19] M. Boothby,et al. Opposing Roles for RelB and Bcl-3 in Regulation of T-Box Expressed in T Cells, GATA-3, and Th Effector Differentiation 1 , 2005, The Journal of Immunology.
[20] M. Zasloff,et al. The nervous system and innate immunity: the neuropeptide connection. , 2005, Nature immunology.
[21] E. Rothenberg,et al. Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. , 2005, Genes & development.
[22] J. L. de la Pompa,et al. RBPjκ-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells , 2005 .
[23] J. Burch,et al. Regulation of GATA gene expression during vertebrate development. , 2005, Seminars in cell & developmental biology.
[24] Pamela L. Schwartzberg,et al. T Helper Cell Fate Specified by Kinase-Mediated Interaction of T-bet with GATA-3 , 2005, Science.
[25] T. Golde,et al. Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21 , 2005, Nature Immunology.
[26] W. Pear,et al. Regulation of lymphoid development, differentiation, and function by the Notch pathway. , 2005, Annual review of immunology.
[27] L. Glimcher,et al. Signaling pathways in Th2 development , 2004, Immunological reviews.
[28] Booki Min,et al. Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses , 2004, Nature Immunology.
[29] E. Pearce,et al. Th2 response polarization during infection with the helminth parasite Schistosoma mansoni , 2004, Immunological reviews.
[30] M. Busslinger,et al. Analysis of Notch1 Function by In Vitro T Cell Differentiation of Pax5 Mutant Lymphoid Progenitors1 , 2004, The Journal of Immunology.
[31] M. Wolfe,et al. Intramembrane Proteolysis: Theme and Variations , 2004, Science.
[32] V. Hartenstein,et al. Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm , 2004, Nature Genetics.
[33] Maki Ukai-Tadenuma,et al. Essential Role of GATA3 for the Maintenance of Type 2 Helper T (Th2) Cytokine Production and Chromatin Remodeling at the Th2 Cytokine Gene Loci* , 2004, Journal of Biological Chemistry.
[34] L. Otten,et al. Notch1 expression on T cells is not required for CD4+ T helper differentiation , 2004, European journal of immunology.
[35] Richard A Flavell,et al. Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells , 2004, Cell.
[36] M. Kubo,et al. Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling , 2004 .
[37] S. Pai,et al. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[38] M. Kubo,et al. Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. , 2004, Immunity.
[39] S. Pai,et al. Critical roles for transcription factor GATA-3 in thymocyte development. , 2003, Immunity.
[40] M. Kapsenberg. Dendritic-cell control of pathogen-driven T-cell polarization , 2003, Nature Reviews Immunology.
[41] H. Hirai,et al. Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. , 2003, Immunity.
[42] Warren Strober,et al. GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet. , 2003, Immunity.
[43] Kenneth M. Murphy,et al. Decision making in the immune system: The lineage decisions of helper T cells , 2002, Nature Reviews Immunology.
[44] H. Asnagli,et al. Cutting Edge: Identification of an Alternative GATA-3 Promoter Directing Tissue-Specific Gene Expression in Mouse and Human1 , 2002, The Journal of Immunology.
[45] T. Honjo,et al. Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells , 2002, Nature Immunology.
[46] T. Yamagata,et al. Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression. , 2001, Blood.
[47] Andrew L. Kung,et al. Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection , 2001, Science.
[48] Prabir Ray,et al. A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation , 2001, Nature Immunology.
[49] S. Barolo,et al. A Notch-Independent Activity of Suppressor of Hairless Is Required for Normal Mechanoreceptor Physiology , 2000, Cell.
[50] Kenneth M. Murphy,et al. Dendritic cell regulation of TH1-TH2 development , 2000, Nature Immunology.
[51] Naoko Arai,et al. Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells , 2000, The Journal of experimental medicine.
[52] Reynaldo Sequerra,et al. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP , 2000, Nature Genetics.
[53] Laurie H Glimcher,et al. A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment , 2000, Cell.
[54] A. Sher,et al. Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile , 2000, The Journal of Immunology.
[55] G. McKenzie,et al. Schistosome Infection of Transgenic Mice Defines Distinct and Contrasting Pathogenic Roles for IL-4 and IL-13: IL-13 Is a Profibrotic Agent1 , 2000, The Journal of Immunology.
[56] F. Finkelman,et al. Stat6 Regulation of In Vivo IL-4 Responses1 , 2000, The Journal of Immunology.
[57] A Radbruch,et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. , 2000, Immunity.
[58] H. Lee,et al. Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. , 1999, Immunity.
[59] H. Macdonald,et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. , 1999, Immunity.
[60] S. Artavanis-Tsakonas,et al. Notch Signaling : Cell Fate Control and Signal Integration in Development , 1999 .
[61] W. Ouyang,et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. , 1998, Immunity.
[62] K. Toellner,et al. CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1 , 1998, The Journal of experimental medicine.
[63] S. Minoguchi,et al. Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. , 1997, Development.
[64] W. Paul,et al. An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[65] A. Ray,et al. Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene* , 1997, The Journal of Biological Chemistry.
[66] Richard A Flavell,et al. The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells , 1997, Cell.
[67] E. Fikrig,et al. Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells , 1997, The Journal of experimental medicine.
[68] Kenneth M. Murphy,et al. Functional diversity of helper T lymphocytes , 1996, Nature.
[69] J. Posakony,et al. Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. , 1995, Genes & development.
[70] T. Mak,et al. Disruption of the mouse RBP-J kappa gene results in early embryonic death. , 1995, Development.
[71] A Radbruch,et al. Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells , 1994, The Journal of experimental medicine.
[72] T. Honjo,et al. Recognition sequence of a highly conserved DNA binding protein RBP-Jx , 1994 .
[73] T. Honjo,et al. Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. , 1994, Nucleic acids research.
[74] R. Coffman,et al. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. , 1989, Annual review of immunology.
[75] K. Warren,et al. DELAYED HYPERSENSITIVITY-TYPE GRANULOMA FORMATION AND DERMAL REACTION INDUCED AND ELICITED BY A SOLUBLE FACTOR ISOLATED FROM SCHISTOSOMA MANSONI EGGS , 1970, The Journal of experimental medicine.