The iOSC3 System: Using Ontologies and SWRL Rules for Intelligent Supervision and Care of Patients with Acute Cardiac Disorders

Physicians in the Intensive Care Unit (ICU) are specially trained to deal constantly with very large and complex quantities of clinical data and make quick decisions as they face complications. However, the amount of information generated and the way the data are presented may overload the cognitive skills of even experienced professionals and lead to inaccurate or erroneous actions that put patients' lives at risk. In this paper, we present the design, development, and validation of iOSC3, an ontology-based system for intelligent supervision and treatment of critical patients with acute cardiac disorders. The system analyzes the patient's condition and provides a recommendation about the treatment that should be administered to achieve the fastest possible recovery. If the recommendation is accepted by the doctor, the system automatically modifies the quantity of drugs that are being delivered to the patient. The knowledge base is constituted by an OWL ontology and a set of SWRL rules that represent the expert's knowledge. iOSC3 has been developed in collaboration with experts from the Cardiac Intensive Care Unit (CICU) of the Meixoeiro Hospital, one of the most significant hospitals in the northwest region of Spain.

[1]  Stefan Decker,et al.  Creating Semantic Web Contents with Protégé-2000 , 2001, IEEE Intell. Syst..

[2]  Y. Donchin,et al.  A look into the nature and causes of human errors in the intensive care unit , 2022 .

[3]  Kei-Hoi Cheung,et al.  Semantic Web: Revolutionizing Knowledge Discovery in the Life Sciences , 2006 .

[4]  Gómez-PérezAsunción,et al.  Methodologies, tools and languages for building ontologies , 2003 .

[5]  J Gotman,et al.  An expert system for EEG monitoring in the pediatric intensive care unit. , 1998, Electroencephalography and clinical neurophysiology.

[6]  H. E. Pople,et al.  Internist-I, an Experimental Computer-Based Diagnostic Consultant for General Internal Medicine , 1982 .

[7]  James M. Blum,et al.  Specificity Improvement for Network Distributed Physiologic Alarms Based on a Simple Deterministic Reactive Intelligent Agent in the Critical Care Environment , 2009, Journal of Clinical Monitoring and Computing.

[8]  Ainhoa Serna Nocedal,et al.  Supporting clinical processes with semantic web technologies: a case in breast cancer treatment , 2010, Int. J. Metadata Semant. Ontologies.

[9]  Shu-Hsien Liao,et al.  Expert system methodologies and applications - a decade review from 1995 to 2004 , 2005, Expert Syst. Appl..

[10]  Huajun Chen,et al.  The Semantic Web , 2011, Lecture Notes in Computer Science.

[11]  Ricardo Colomo Palacios,et al.  ODDIN: Ontology-driven differential diagnosis based on logical inference and probabilistic refinements , 2010, Expert Syst. Appl..

[12]  H. Lan,et al.  SWRL : A semantic Web rule language combining OWL and ruleML , 2004 .

[13]  Keith Darlington,et al.  Designing for Explanation in Health Care Applications of Expert Systems , 2011 .

[14]  Daniel E. O'Leary,et al.  PERFORMING AND MANAGING EXPERT SYSTEM VALIDATION , 2009 .

[15]  Patrick Brézillon,et al.  Lecture Notes in Artificial Intelligence , 1999 .

[16]  Rung Ching Chen,et al.  A recommendation system based on domain ontology and SWRL for anti-diabetic drugs selection , 2012, Expert Syst. Appl..

[17]  G. Capellier,et al.  Medication errors at the administration stage in an intensive care unit , 1999, Intensive Care Medicine.

[18]  N. D. de Keizer,et al.  Analysis and Design of an Ontology for Intensive Care Diagnoses , 1999, Methods of Information in Medicine.

[19]  Ivar Jacobson,et al.  The unified software development process - the complete guide to the unified process from the original designers , 1999, Addison-Wesley object technology series.

[20]  Samson W. Tu,et al.  Querying the Semantic Web with SWRL , 2007, RuleML.

[21]  Christopher G. Chute,et al.  BioPortal: ontologies and integrated data resources at the click of a mouse , 2009, Nucleic Acids Res..

[22]  Alexander C. Yu,et al.  Methods in biomedical ontology , 2006, J. Biomed. Informatics.

[23]  Edward H. Shortliffe,et al.  Computer-based medical consultations, MYCIN , 1976 .

[24]  H. Stelfox,et al.  Medication errors in critical care: risk factors, prevention and disclosure , 2009, Canadian Medical Association Journal.

[25]  C. Holzmueller,et al.  Defining and measuring patient safety. , 2005, Critical care clinics.

[26]  Alejandro Pazos,et al.  A Multi-criteria Approach for Automatic Ontology Recommendation Using Collective Knowledge , 2012, Recommender Systems for the Social Web.

[27]  M. Ashburner,et al.  The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration , 2007, Nature Biotechnology.

[28]  Sudip Sanyal,et al.  Hybrid approach using case-based reasoning and rule-based reasoning for domain independent clinical decision support in ICU , 2009, Expert Syst. Appl..

[29]  Osman Balci,et al.  Validation of Expert System Performance , 1986 .

[30]  Asunción Gómez-Pérez,et al.  Building a chemical ontology using Methontology and the Ontology Design Environment , 1999, IEEE Intell. Syst..

[31]  Patrice Degoulet,et al.  Terminology extraction from text to build an ontology in surgical intensive care , 2002, AMIA.

[32]  Dan Brickley,et al.  Resource Description Framework (RDF) Model and Syntax Specification , 2002 .

[33]  F. T. de Dombal,et al.  Human and Computer-aided Diagnosis of Abdominal Pain: Further Report with Emphasis on Performance of Clinicians , 1974, British medical journal.

[34]  L. Stein,et al.  OWL Web Ontology Language - Reference , 2004 .

[35]  Asunción Gómez-Pérez,et al.  Methodologies, tools and languages for building ontologies: Where is their meeting point? , 2003, Data Knowl. Eng..

[36]  Cristian R. Munteanu,et al.  An Approach for the Automatic Recommendation of Ontologies Using Collaborative Knowledge , 2010, KES.

[37]  Raphael Volz,et al.  The Ontology Extraction & Maintenance Framework Text-To-Onto , 2001 .

[38]  M. Cevdet Ince,et al.  An expert system for detection of breast cancer based on association rules and neural network , 2009, Expert Syst. Appl..

[39]  E. Shortliffe Clinical decision-support systems , 1990 .

[40]  Suzanne Smith,et al.  Verification and validation of rule-based expert systems , 1993 .

[41]  Michael Lawrence,et al.  The effects of structural characteristics of explanations on use of a DSS , 2006, Decis. Support Syst..

[42]  Lee W. Lacy OWL: Representing Information Using the Web Ontology Language , 2006 .

[43]  Thomas R. Gruber,et al.  The Role of Common Ontology in Achieving Sharable, Reusable Knowledge Bases , 1991, KR.

[44]  O. Bodenreider,et al.  Clinical Ontologies for Discovery Applications , 2007 .

[45]  Asunción Gómez-Pérez,et al.  METHONTOLOGY: From Ontological Art Towards Ontological Engineering , 1997, AAAI 1997.

[46]  Ivar Jacobson,et al.  The Unified Software Development Process , 1999 .

[47]  H. Ying,et al.  Regulating mean arterial pressure in postsurgical cardiac patients. A fuzzy logic system to control administration of sodium nitroprusside , 1994, IEEE Engineering in Medicine and Biology Magazine.

[48]  Yarden Katz,et al.  Pellet: A practical OWL-DL reasoner , 2007, J. Web Semant..