Serotonin2A receptor-like immunoreactivity in rat cerebellar Purkinje cells

In the present study we examined the distribution pattern of serotonin2A (5-HT2A) receptors in the rat cerebellum. A strong immunoreaction against 5-HT2A receptor protein was observed in Purkinje cells. A dense cluster of immunopositive dendritic profiles of Purkinje cells was located beneath the pia matter of cerebellar cortex. Somal profiles in the cerebellar nuclei had weak to moderate immunoreactions.

[1]  S. Hamada,et al.  The cellular localization of 5-HT2A receptors in the spinal cord and spinal ganglia of the adult rat , 1998, Brain Research.

[2]  M. Mikuni,et al.  Regulation of synapse density by 5-HT2A receptor agonist and antagonist in the spinal cord of chicken embryo , 1995, Neuroscience Letters.

[3]  M. Pompeiano,et al.  Localization of the mRNA for the 5-HT2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites , 1990, Brain Research.

[4]  L. Hokin,et al.  Agonist‐Stimulated Inositol Polyphosphate Formation in Cerebellum , 1992, Journal of neurochemistry.

[5]  M. Raiteri,et al.  5-HT2 presynaptic receptors mediate inhibition of glutamate release from cerebellar mossy fibre terminals. , 1991, European journal of pharmacology.

[6]  J. Palacios,et al.  Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors , 1987, Neuroscience.

[7]  J. Palacios,et al.  Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors , 1985, Brain Research.

[8]  Yue Wang,et al.  Serotonin alters an inwardly rectifying current (Ih ) in rat cerebellar Purkinje cells under voltage clamp , 1993, Brain Research.

[9]  B. Roth Multiple serotonin receptors: clinical and experimental aspects. , 1994, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

[10]  M. Pompeiano,et al.  Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. , 1994, Brain research. Molecular brain research.

[11]  C. Fischette,et al.  Effects of 5, 7-dihydroxytryptamine on serotonin1 and serotonin2 receptors throughout the rat central nervous system using quantitative autoradiography , 1987, Brain Research.

[12]  S. Hamada,et al.  Localization of 5-HT2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken. , 1998, Brain research. Molecular brain research.

[13]  Paul J. Harrison,et al.  The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain , 1995, Brain Research.