Integrated Molecular Characterization of Testicular Germ Cell Tumors

[1]  David Haussler,et al.  TumorMap: Exploring the Molecular Similarities of Cancer Samples in an Interactive Portal. , 2017, Cancer research.

[2]  Robert Karlsson,et al.  Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor , 2017, Nature Genetics.

[3]  C. Bokemeyer,et al.  Serum Levels of MicroRNA miR-371a-3p: A Sensitive and Specific New Biomarker for Germ Cell Tumours. , 2017, European urology.

[4]  B. Christensen,et al.  Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine , 2016, Oncotarget.

[5]  D. O. Vidal,et al.  MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients , 2016, Oncotarget.

[6]  S. Gabriel,et al.  Genomic evolution and chemoresistance in germ-cell tumours , 2016, Nature.

[7]  P. Humphrey,et al.  The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. , 2016, European urology.

[8]  R. Huddart,et al.  The genomic landscape of testicular germ cell tumours: from susceptibility to treatment , 2016, Nature Reviews Urology.

[9]  Kenneth L. Jones,et al.  Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer. , 2016, JCI insight.

[10]  M. Beckmann,et al.  Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses , 2016, Cell.

[11]  Eve Shinbrot,et al.  Mutation signatures reveal biological processes in human cancer , 2016, bioRxiv.

[12]  D. Berney,et al.  Defining a New Prognostic Index for Stage I Nonseminomatous Germ Cell Tumors Using CXCL12 Expression and Proportion of Embryonal Carcinoma , 2015, Clinical Cancer Research.

[13]  Trevor J Pugh,et al.  DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts , 2015, Cell.

[14]  C. Ong,et al.  Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas. , 2015, European urology.

[15]  R. Lothe,et al.  Exome Sequencing of Bilateral Testicular Germ Cell Tumors Suggests Independent Development Lineages12 , 2015, Neoplasia.

[16]  S. Seal,et al.  Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours , 2015, Nature Communications.

[17]  G. Kristiansen,et al.  Circulating serum miRNA (miR-367-3p, miR-371a-3p, miR-372-3p and miR-373-3p) as biomarkers in patients with testicular germ cell cancer. , 2015, The Journal of urology.

[18]  Junfeng Zhang,et al.  Investigation of microRNA expression in human serum during the aging process. , 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

[19]  S. Socorro,et al.  The SCF/c‐KIT system in the male: Survival strategies in fertility and cancer , 2014, Molecular reproduction and development.

[20]  Gabor T. Marth,et al.  Novel somatic and germline mutations in intracranial germ cell tumours , 2014, Nature.

[21]  V. Reuter,et al.  Presence of Somatic Mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in Cisplatin-Resistant Germ Cell Tumors , 2014, Clinical Cancer Research.

[22]  Julie V. Harness,et al.  Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment , 2014, Genome research.

[23]  S. Gabriel,et al.  Discovery and saturation analysis of cancer genes across 21 tumor types , 2014, Nature.

[24]  N. Skakkebaek,et al.  Phenotypic characterisation of immune cell infiltrates in testicular germ cell neoplasia. , 2013, Journal of reproductive immunology.

[25]  K. Siegmund,et al.  Null association between histology of first and second primary malignancies in men with bilateral testicular germ cell tumors. , 2013, American journal of epidemiology.

[26]  S. Sleijfer,et al.  MiR-17-92 and miR-221/222 cluster members target KIT and ETV1 in human gastrointestinal stromal tumours , 2013, British Journal of Cancer.

[27]  David T. W. Jones,et al.  Signatures of mutational processes in human cancer , 2013, Nature.

[28]  H. Brenner,et al.  Survival after a diagnosis of testicular germ cell cancers in Germany and the United States, 2002-2006: a high resolution study by histology and age. , 2013, Cancer epidemiology.

[29]  Nazneen Rahman,et al.  Meta-analysis identifies four new loci associated with testicular germ cell tumor , 2013, Nature Genetics.

[30]  Peter W. Laird,et al.  Interplay between the Cancer Genome and Epigenome , 2013, Cell.

[31]  K. Berhane,et al.  Cryptorchidism and testicular germ cell tumors: comprehensive meta-analysis reveals that association between these conditions diminished over time and is modified by clinical characteristics , 2012, Front. Endocrin..

[32]  R. Chaganti,et al.  Reduced Proficiency in Homologous Recombination Underlies the High Sensitivity of Embryonal Carcinoma Testicular Germ Cell Tumors to Cisplatin and Poly (ADP-Ribose) Polymerase Inhibition , 2012, PloS one.

[33]  S. Fosså,et al.  Contemporary management of postchemotherapy testis cancer. , 2012, European urology.

[34]  Gangning Liang,et al.  DNA methylation screening identifies driver epigenetic events of cancer cell survival. , 2012, Cancer cell.

[35]  A. McKenna,et al.  Absolute quantification of somatic DNA alterations in human cancer , 2012, Nature Biotechnology.

[36]  Benjamin J. Raphael,et al.  Integrated Genomic Analyses of Ovarian Carcinoma , 2011, Nature.

[37]  F. Mallet,et al.  Custom human endogenous retroviruses dedicated microarray identifies self-induced HERV-W family elements reactivated in testicular cancer upon methylation control , 2010, Nucleic acids research.

[38]  Lee E. Edsall,et al.  Human DNA methylomes at base resolution show widespread epigenomic differences , 2009, Nature.

[39]  Nandita Mitra,et al.  Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer , 2009, Nature Genetics.

[40]  Atul J Butte,et al.  MicroRNA profiling of human-induced pluripotent stem cells. , 2009, Stem cells and development.

[41]  Andrew J. G. Simpson,et al.  CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens , 2008, Nucleic Acids Res..

[42]  J. Hicks,et al.  Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors , 2008, Modern Pathology.

[43]  P. Laird,et al.  Epigenetic stem cell signature in cancer , 2007, Nature Genetics.

[44]  Yun-Fai Chris Lau,et al.  Germ cell lineage differentiation in non‐seminomatous germ cell tumours , 2006, The Journal of pathology.

[45]  R. Huddart,et al.  Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults. , 2005, Cancer research.

[46]  Jinbo Chen,et al.  Risk of contralateral testicular cancer: a population-based study of 29,515 U.S. men. , 2005, Journal of the National Cancer Institute.

[47]  R. Huddart,et al.  Defining minimum genomic regions of imbalance involved in testicular germ cell tumors of adolescents and adults through genome wide microarray analysis of cDNA clones , 2004, Oncogene.

[48]  D. Gisselsson,et al.  A model for karyotypic evolution in testicular germ cell tumors , 2004, Genes, chromosomes & cancer.

[49]  J. Habbema,et al.  Predictors of occult metastasis in clinical stage I nonseminoma: a systematic review. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[50]  H. Leffers,et al.  High‐resolution comparative genomic hybridization detects extra chromosome arm 12p material in most cases of carcinoma in situ adjacent to overt germ cell tumors, but not before the invasive tumor development , 2003, Genes, chromosomes & cancer.

[51]  E. Maher,et al.  Frequent epigenetic inactivation of the RASSF1A tumour suppressor gene in testicular tumours and distinct methylation profiles of seminoma and nonseminoma testicular germ cell tumours , 2003, Oncogene.

[52]  V. Reuter,et al.  Characteristic promoter hypermethylation signatures in male germ cell tumors , 2002, Molecular Cancer.

[53]  C. Parker,et al.  The prognostic significance of the tumour infiltrating lymphocyte count in stage I testicular seminoma managed by surveillance. , 2002, European journal of cancer.

[54]  C. Plass,et al.  Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors , 2002, Oncogene.

[55]  R. Huddart,et al.  Chromosomal imbalances associated with carcinoma in situ and associated testicular germ cell tumours of adolescents and adults , 2001, British Journal of Cancer.

[56]  L. Looijenga,et al.  Comparative Genomic and In Situ Hybridization of Germ Cell Tumors of the Infantile Testis , 2000, Laboratory Investigation.

[57]  C. Moskaluk,et al.  Activating c-kit gene mutations in human germ cell tumors. , 1999, The American journal of pathology.

[58]  N. Jørgensen,et al.  DNA content and expression of tumour markers in germ cells adjacent to germ cell tumours in childhood: Probably A different origin for infantile and adolescent germ cell tumours , 1995, The Journal of pathology.

[59]  A. Langeveld,et al.  Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells. , 1989, Cancer genetics and cytogenetics.