Genome wide association study identifies novel potential candidate genes for bovine milk cholesterol content

[1]  F. Schenkel,et al.  Genetic parameters of milk cholesterol content in Holstein cattle , 2018, Canadian Journal of Animal Science.

[2]  I. Schulman Liver X receptors link lipid metabolism and inflammation , 2017, FEBS letters.

[3]  P. Strzyz Cell Senescence: A new role for ATM , 2017, Nature Reviews Molecular Cell Biology.

[4]  P. Strzyz Lipid Metabolism: Cholesterol feeds into cell growth control , 2017, Nature Reviews Molecular Cell Biology.

[5]  J. Iqbal,et al.  Hexim1 heterozygosity stabilizes atherosclerotic plaque and decreased steatosis in ApoE null mice fed atherogenic diet. , 2017, The international journal of biochemistry & cell biology.

[6]  C. Albrecht,et al.  In vitro characterization and endocrine regulation of cholesterol and phospholipid transport in the mammary gland , 2017, Molecular and Cellular Endocrinology.

[7]  Dianfan Li,et al.  Cholesterol homeostasis: How do cells sense sterol excess? , 2016, Chemistry and physics of lipids.

[8]  E. Ibeagha-Awemu,et al.  High density genome wide genotyping-by-sequencing and association identifies common and low frequency SNPs, and novel candidate genes influencing cow milk traits , 2016, Scientific Reports.

[9]  A. Zimmer,et al.  Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism , 2016, Biochimica et biophysica acta.

[10]  M. Woodward,et al.  Total cholesterol as a risk factor for coronary heart disease and stroke in women compared with men: A systematic review and meta-analysis. , 2016, Atherosclerosis.

[11]  Amy E. Morgan,et al.  Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation , 2016, Ageing Research Reviews.

[12]  G. Morahan,et al.  A common variant association study reveals novel susceptibility loci for low HDL‐cholesterol levels in ethnic Arabs , 2016, Clinical genetics.

[13]  P. Dudemaine,et al.  Transcriptome adaptation of the bovine mammary gland to diets rich in unsaturated fatty acids shows greater impact of linseed oil over safflower oil on gene expression and metabolic pathways , 2016, BMC Genomics.

[14]  Sanghoon Moon,et al.  Genome-wide association study of serum lipids confirms previously reported associations as well as new associations of common SNPs within PCSK7 gene with triglyceride , 2016, Journal of Human Genetics.

[15]  U. Kulozik,et al.  Temporal variation of milk fat globule diameter, fat and cholesterol content and milk epithelial cell gene expression in dairy cows , 2015 .

[16]  Y. Jang,et al.  The Impact of CDH13 Polymorphism and Statin Administration on TG/HDL Ratio in Cardiovascular Patients , 2015, Yonsei medical journal.

[17]  D. Rader,et al.  Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study , 2015, The lancet. Diabetes & endocrinology.

[18]  J. Gross,et al.  Response of the Cholesterol Metabolism to a Negative Energy Balance in Dairy Cows Depends on the Lactational Stage , 2015, PloS one.

[19]  E. Arenas Faculty Opinions recommendation of Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. , 2015 .

[20]  J. Mathers,et al.  Effects of the Dietary Approach to Stop Hypertension (DASH) diet on cardiovascular risk factors: a systematic review and meta-analysis. , 2015, The British journal of nutrition.

[21]  Davide Heller,et al.  STRING v10: protein–protein interaction networks, integrated over the tree of life , 2014, Nucleic Acids Res..

[22]  N. Davidson,et al.  Epigenetic reprogramming in breast cancer: From new targets to new therapies , 2014, Annals of medicine.

[23]  J. Gross,et al.  Cholesterol metabolism, transport, and hepatic regulation in dairy cows during transition and early lactation. , 2014, Journal of dairy science.

[24]  P. Ridker LDL cholesterol: controversies and future therapeutic directions , 2014, The Lancet.

[25]  F. Schenkel,et al.  A new approach for efficient genotype imputation using information from relatives , 2014, BMC Genomics.

[26]  Qin Zhang,et al.  Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein , 2014, PloS one.

[27]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[28]  Kuljeet Singh,et al.  The Role of Tight Junctions in Mammary Gland Function , 2014, Journal of Mammary Gland Biology and Neoplasia.

[29]  M. Rychlik,et al.  Effects of rapeseed and soybean oil dietary supplementation on bovine fat metabolism, fatty acid composition and cholesterol levels in milk , 2013, Journal of Dairy Research.

[30]  R. Bruckmaier,et al.  Hepatic gene expression involved in glucose and lipid metabolism in transition cows: effects of fat mobilization during early lactation in relation to milk performance and metabolic changes. , 2013, Journal of dairy science.

[31]  H. Lu,et al.  Enhancer of zeste homolog 2 activates wnt signaling through downregulating CXXC finger protein 4 , 2013, Cell Death and Disease.

[32]  C. Albrecht,et al.  Characteristics and Functional Relevance of Apolipoprotein-A1 and Cholesterol Binding in Mammary Gland Tissues and Epithelial Cells , 2013, PloS one.

[33]  Xueyuan Cao,et al.  Polymorphisms of PTPN11 gene could influence serum lipid levels in a sex-specific pattern , 2013, Lipids in Health and Disease.

[34]  E. Chen,et al.  Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool , 2013, BMC Bioinformatics.

[35]  R. Summers,et al.  Relaxin family peptides and their receptors. , 2013, Physiological reviews.

[36]  Xiaolong Wang,et al.  Identification and Dissection of Four Major QTL Affecting Milk Fat Content in the German Holstein-Friesian Population , 2012, PloS one.

[37]  R. Ringseis,et al.  Changes in the expression of hepatic genes involved in cholesterol homeostasis in dairy cows in the transition period and at different stages of lactation. , 2012, Journal of dairy science.

[38]  Lisa J. Martin,et al.  Accounting for a Quantitative Trait Locus for Plasma Triglyceride Levels: Utilization of Variants in Multiple Genes , 2012, PloS one.

[39]  Y. Kokubo,et al.  CDH13 gene coding t‐cadherin influences variations in plasma adiponectin levels in the Japanese population , 2012, Human mutation.

[40]  H. Ahammer,et al.  Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice , 2011, Biochimica et biophysica acta.

[41]  G. Ness,et al.  Mechanism of Resistance to Dietary Cholesterol , 2011, Journal of lipids.

[42]  C. Carlson,et al.  Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study , 2011, PLoS genetics.

[43]  M. T. Sorensen,et al.  Identification of ABCA1 and ABCG1 in milk fat globules and mammary cells--implications for milk cholesterol secretion. , 2011, Journal of dairy science.

[44]  D. Figeys,et al.  Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism. , 2010, Biochimica et biophysica acta.

[45]  C. Wijmenga,et al.  Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study. , 2010, Atherosclerosis.

[46]  P. Ma,et al.  Genome Wide Association Studies for Milk Production Traits in Chinese Holstein Population , 2010, PloS one.

[47]  Avi Ma'ayan,et al.  ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments , 2010, Bioinform..

[48]  M. Olivier,et al.  Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels. , 2010, Physiological genomics.

[49]  J. A. Arias,et al.  Epigenetic Regulation of Milk Production in Dairy Cows , 2010, Journal of Mammary Gland Biology and Neoplasia.

[50]  Aaron R. Quinlan,et al.  BIOINFORMATICS APPLICATIONS NOTE , 2022 .

[51]  Jihong Han,et al.  Inhibition of ERK1/2 and Activation of Liver X Receptor Synergistically Induce Macrophage ABCA1 Expression and Cholesterol Efflux* , 2009, The Journal of Biological Chemistry.

[52]  M. Kaske,et al.  Cholesterol synthesis in the lactating cow: Induced expression of candidate genes , 2009, The Journal of Steroid Biochemistry and Molecular Biology.

[53]  Hiromu Suzuki,et al.  Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling , 2009, Oncogene.

[54]  Christian Gieger,et al.  Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts , 2009, Nature Genetics.

[55]  Fan Lan,et al.  SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase* , 2008, Journal of Biological Chemistry.

[56]  D. Strachan,et al.  LDL-cholesterol concentrations: a genome-wide association study , 2008, The Lancet.

[57]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[58]  H. Snieder,et al.  SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women. , 2007, Atherosclerosis.

[59]  A. Gotto,et al.  HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. , 2007, The New England journal of medicine.

[60]  Simon C. Potter,et al.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.

[61]  Ole F. Christensen,et al.  Proceedings, 10 World Congress of Genetics Applied to Livestock Production DMU - A Package for Analyzing Multivariate Mixed Models in quantitative Genetics and Genomics , 2014 .

[62]  S. Bray Notch signalling: a simple pathway becomes complex , 2006, Nature Reviews Molecular Cell Biology.

[63]  S. Patton,et al.  Origins of the cholesterol in milk , 1980, Lipids.

[64]  M. Eilers,et al.  Transcriptional regulation and transformation by Myc proteins , 2005, Nature Reviews Molecular Cell Biology.

[65]  S. Miura,et al.  Increased Very Low Density Lipoprotein Secretion and Gonadal Fat Mass in Mice Overexpressing Liver DGAT1* , 2005, Journal of Biological Chemistry.

[66]  Mark Daly,et al.  Haploview: analysis and visualization of LD and haplotype maps , 2005, Bioinform..

[67]  S. Davis,et al.  Decreased expression of β1‐integrin and focal adhesion kinase in epithelial cells may initiate involution of mammary glands , 2004, Journal of cellular physiology.

[68]  Michel Georges,et al.  Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[69]  H. Thomsen,et al.  The DGAT1 K232A mutation is not solely responsible for the milk production quantitative trait locus on the bovine chromosome 14. , 2004, Journal of dairy science.

[70]  U. Lendahl,et al.  Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. , 2004, Experimental cell research.

[71]  R. Fries,et al.  Assessment of the gene content of the chromosomal regions flanking bovine DGAT1. , 2004, Genomics.

[72]  D. Hardie Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/en.2003-0982 Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status , 2022 .

[73]  J. Breslow,et al.  Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mices⃞s⃞ The online version of this article (available at http://www.jlr.org) contains one supplemental table. Published, JLR Papers in Press, August 1, 2003. DOI 10.1194/jlr.M300203-JLR200 , 2003, Journal of Lipid Research.

[74]  Hitoshi Shimano,et al.  Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling. , 2003, Molecular endocrinology.

[75]  Didier Boichard,et al.  Detection of genes influencing economic traits in three French dairy cattle breeds , 2003, Genetics Selection Evolution.

[76]  M. de Oya,et al.  Food sources of nutrients in the diet of Spanish children: the Four Provinces Study , 2003, British Journal of Nutrition.

[77]  B. A. Janowski The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[78]  R. Aebersold,et al.  Crucial Step in Cholesterol Homeostasis Sterols Promote Binding of SCAP to INSIG-1, a Membrane Protein that Facilitates Retention of SREBPs in ER , 2002, Cell.

[79]  S. Gabriel,et al.  The Structure of Haplotype Blocks in the Human Genome , 2002, Science.

[80]  Yanhong Shi,et al.  The peroxisome proliferator-activated receptor δ, an integrator of transcriptional repression and nuclear receptor signaling , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[81]  R. G. Jensen The composition of bovine milk lipids: January 1995 to December 2000. , 2002, Journal of dairy science.

[82]  S. Kliewer,et al.  A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[83]  E. Ikonen,et al.  How cells handle cholesterol. , 2000, Science.

[84]  Jean-Marc A. Lobaccaro,et al.  Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ , 2000 .

[85]  M. Peaker,et al.  Transport of milk constituents by the mammary gland. , 2000, Physiological reviews.

[86]  I. Shimomura,et al.  Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. , 2000, Genes & development.

[87]  D. Fletouris,et al.  Rapid determination of cholesterol in milk and milk products by direct saponification and capillary gas chromatography. , 1998, Journal of dairy science.

[88]  R. Hammer,et al.  Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα , 1998, Cell.

[89]  J. Hokanson,et al.  Plasma Triglyceride Level is a Risk Factor for Cardiovascular Disease Independent of High-Density Lipoprotein Cholesterol Level: A Metaanalysis of Population-Based Prospective Studies , 1996, Journal of cardiovascular risk.

[90]  B. Groner,et al.  Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[91]  E. Nigg,et al.  Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[92]  H. Cheng,et al.  Zonation of cholesterol and glycerolipid synthesis in regenerating rat livers , 1993, Hepatology.

[93]  G. Vassaux,et al.  Cholesterol efflux from adipose cells is coupled to diacylglycerol production and protein kinase C activation. , 1990, Biochemical and biophysical research communications.

[94]  A. Sim,et al.  The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolism , 1989 .

[95]  P. Yeagle Cholesterol and the cell membrane. , 1985, Biochimica et biophysica acta.

[96]  P. Leder,et al.  Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor , 1983, Cell.

[97]  R. G. Jensen Composition of bovine milk lipids , 1973, Journal of the American Oil Chemists' Society.

[98]  U. Bracco,et al.  Lipid composition of the fat globule membrane of human and bovine milk. , 1972, Journal of dairy science.