Silver or silver nanoparticles: a hazardous threat to the environment and human health?

Nanotechnology is a rapidly growing science of producing and utilizing nano-sized particles that measure in nanometers. These nanomaterials are already having an impact on health care. Now-a-days we are using nanoproducts in various fields. Of these, silver nanoparticles are playing a major role in the field of nanotechnology and nanomedicine. Their unique size-dependent properties make these materials superior and indispensable as they show unusual physical, chemical and biological properties. Silver nanoparticles have potential antimicrobial activity towards many pathogenic microbes. Along with this antimicrobial activity, silver nanoparticles are showing unacceptable toxic effects on human health and the environment. The chronic exposure to silver causes adverse effects such as permanent bluish-grey discoloration of the skin (argyria) and eyes (argyrosis). Besides argyria and argyrosis, exposure to soluble silver compounds may produce other toxic effects like liver and kidney damage, irritation of the eyes, skin, respiratory and intestinal tract and changes to blood cells. This review summarizes the hazardous effects of silver nanoparticles in the environment and theirs toxic effects on human health.

[1]  L. Murr,et al.  Cytotoxic Responses and Potential Respiratory Health Effects of Carbon and Carbonaceous Nanoparticulates in the Paso del Norte Airshed Environment , 2008, International journal of environmental research and public health.

[2]  Saber M Hussain,et al.  The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[3]  Younan Xia,et al.  Shape-Controlled Synthesis of Gold and Silver Nanoparticles , 2002, Science.

[4]  C. McClain,et al.  Serum and urinary silver levels in thermal injury patients. , 1987, Surgery.

[5]  K. Rosenman,et al.  Argyria: clinical implications of exposure to silver nitrate and silver oxide. , 1979, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[6]  E. Capodaglio,et al.  Effects of silver in isolated rat hepatocytes. , 1988, Toxicology letters.

[7]  S. Saint,et al.  The potential clinical and economic benefits of silver alloy urinary catheters in preventing urinary tract infection. , 2000, Archives of internal medicine.

[8]  R. Lazova,et al.  Scar-localized argyria secondary to silver sulfadiazine cream. , 2003, Journal of the American Academy of Dermatology.

[9]  J. Guggenbichler,et al.  Prevention of catheter-related infections: the potential of a new nano-silver impregnated catheter. , 2004, International journal of antimicrobial agents.

[10]  Seung Hun Lee,et al.  Generalized Argyria after Habitual Use of AgNO3 , 1994, The Journal of dermatology.

[11]  N. Bogdanchikova,et al.  Structure of silver clusters embedded in erionite channels , 1999 .

[12]  Robert N Grass,et al.  Exposure of engineered nanoparticles to human lung epithelial cells: influence of chemical composition and catalytic activity on oxidative stress. , 2007, Environmental science & technology.

[13]  N. Seixas,et al.  Potential nephrotoxic effects of exposure to silver. , 1987, British journal of industrial medicine.

[14]  Lawrence J. Albright,et al.  Sub-lethal effects of several metallic salts—organic compounds combinations upon the heterotrophic microflora of a natural water , 1974 .

[15]  Asymptomatic blue nevus-like macule. Diagnosis: localized argyria. , 1996, Archives of dermatology.

[16]  M. Yacamán,et al.  The bactericidal effect of silver nanoparticles , 2005, Nanotechnology.

[17]  Sueki,et al.  Two unusual cases of argyria: the application of an improved tissue processing method for X‐ray microanalysis of selenium and sulphur in silver‐laden granules , 1999, The British journal of dermatology.

[18]  Wolfgang Kreyling,et al.  Toxicological hazards of inhaled nanoparticles--potential implications for drug delivery. , 2004, Journal of nanoscience and nanotechnology.

[19]  J. Rungby,et al.  Neuronal accumulation of silver in brains of progeny from argyric rats , 2004, Acta Neuropathologica.

[20]  M Lippmann,et al.  Deposition, retention, and clearance of inhaled particles. , 1980, British journal of industrial medicine.

[21]  P. Mehraein,et al.  Brain involvement in generalized argyria. , 1984, Clinical neuropathology.

[22]  V. Poon,et al.  Antimicrobial activities of silver dressings: an in vitro comparison. , 2006, Journal of medical microbiology.

[23]  R. Russell‐Jones,et al.  Severe generalized argyria secondary to ingestion of colloidal silver protein , 2003, Clinical and experimental dermatology.

[24]  Scott Kg,et al.  The metabolism of silver in the rat with radio-silver used as an indicator. , 1950 .

[25]  J. Schlager,et al.  In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[26]  K. Watanabe [Histopathological study of damage to periodontal tissues by silver alloy metals in rats]. , 1989, Nihon Shishubyo Gakkai kaishi.

[27]  V. Bhoraskar,et al.  Silver nanoparticles: synthesis and size control by electron irradiation , 2006 .

[28]  E. Merian Metal toxicity in mammals: Edited by D. Luckey and B. Venugopal , 1980 .

[29]  O. Nishimura,et al.  Synthesis of silver nanoparticles by laser ablation in pure water , 2004 .

[30]  G. Sergeev,et al.  Cryochemical synthesis and properties of silver nanoparticle dispersions stabilised by poly(2-dimethylaminoethyl methacrylate) , 1999 .

[31]  M. Yacamán,et al.  Interaction of silver nanoparticles with HIV-1 , 2005, Journal of nanobiotechnology.

[32]  H. K. Wilson,et al.  The determination of silver in whole blood and its application to biological monitoring of occupationally exposed groups. , 1996, The Annals of occupational hygiene.

[33]  Mark R Wiesner,et al.  Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. , 2006, Nano letters.

[34]  L. Baden,et al.  "Images in clinical medicine". , 2001, Connecticut medicine.

[35]  R Heinrich,et al.  Formation of large clusters during sputtering of silver , 2000 .

[36]  S. Brooks Lung disorders resulting from the inhalation of metals. , 1981, Clinics in chest medicine.

[37]  Kurlemann,et al.  A Medical Mystery. , 2000, The New England journal of medicine.

[38]  Chi-Ming Che,et al.  Proteomic analysis of the mode of antibacterial action of silver nanoparticles. , 2006, Journal of proteome research.

[39]  Helmut Sigel,et al.  Handbook on toxicity of inorganic compounds , 1990 .

[40]  Yajun Wang,et al.  Synthesis of silver nanoparticles via electrochemical reduction on compact zeolite film modified electrodes. , 2002, Chemical Communications.

[41]  R. Pariser Generalized argyria. Clinicopathologic features and histochemical studies. , 1978, Archives of dermatology.

[42]  C. Wood,et al.  Physiology and modeling of mechanisms of silver uptake and toxicity in fish , 1999 .

[43]  Y. Sue,et al.  Generalized argyria in two chronic hemodialysis patients. , 2001, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[44]  黄亚明 eMedicine , 2009 .

[45]  Theerayuth Kaewamatawong,et al.  Acute and Subacute Pulmonary Toxicity of Low Dose of Ultrafine Colloidal Silica Particles in Mice after Intratracheal Instillation , 2006, Toxicologic pathology.

[46]  U. Heinzmann,et al.  Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. , 2001, Environmental health perspectives.

[47]  W. R. Lee,et al.  Argyrosis of the lacrimal sac , 2005, Graefe's Archive for Clinical and Experimental Ophthalmology.

[48]  Bouts Ba Images in clinical medicine. Argyria. , 1999 .

[49]  J. Marshall,et al.  Systemic argyria secondary to topical silver nitrate. , 1977, Archives of dermatology.

[50]  D. W. Fassett,et al.  Localized Argyria: II. Chemical Nature of the Silver Containing Particles , 1965 .

[51]  J. Davis,et al.  Sources, transport, fate, and toxicity of pollutants in the San Francisco Bay estuary. , 2007, Environmental research.

[52]  R. Hansen,et al.  Argyria following the use of dietary supplements containing colloidal silver protein. , 2000, Cutis.

[53]  A. Rebora,et al.  Blue nevi-like dotted occupational argyria. , 1992, Journal of the American Academy of Dermatology.

[54]  Kimberly Wise,et al.  Single-walled carbon nanotubes induces oxidative stress in rat lung epithelial cells. , 2007, Journal of nanoscience and nanotechnology.

[55]  S. Gullans,et al.  Silver ion (Ag+)-Induced increases in cell membrane K+ and Na+ permeability in the renal proximal tubule: Reversal by thiol reagents , 1988, The Journal of Membrane Biology.

[56]  J. Rungby,et al.  Localization of exogenous silver in brain and spinal cord of silver exposed rats , 2004, Acta Neuropathologica.

[57]  S. Hallin,et al.  Silver (Ag+) reduces denitrification and induces enrichment of novel nirK genotypes in soil. , 2007, FEMS microbiology letters.

[58]  T. Takamatsu,et al.  Effects Of Pb, Cu, Sb, In and Ag Contamination on the Proliferation of Soil Bacterial Colonies, Soil Dehydrogenase Activity, and Phospholipid Fatty Acid Profiles of Soil Microbial Communities , 2005 .

[59]  S. Graham,et al.  The feasibility of measuring silver concentrations in vivo with x-ray fluorescence. , 2004, Physics in medicine and biology.

[60]  H. Jacobe,et al.  Argyria secondary to ingestion of homemade silver solution. , 2005, Journal of the American Academy of Dermatology.

[61]  P. Drake,et al.  Exposure-related health effects of silver and silver compounds: a review. , 2005, The Annals of occupational hygiene.

[62]  P. Morrow,et al.  Experimental inhalation of metallic silver. , 1973, Health physics.

[63]  William Robinson Hill,et al.  Argyria : the pharmacology of silver , 1939 .

[64]  Michael Wagener,et al.  An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement. , 2004, Biomaterials.

[65]  M. Fung,et al.  Silver products for medical indications: risk-benefit assessment. , 1996, Journal of toxicology. Clinical toxicology.

[66]  Zhao Yan-li Antibacterial Materials of Silver Nanoparticles Application in Medical Appliances and Appliances for Daily Use , 2004 .

[67]  V. Sulica,et al.  Allergy to silver amalgams. , 1978, Oral surgery, oral medicine, and oral pathology.

[68]  M. Espinel,et al.  Asymptomatic blue nevus-like macule , 1996 .

[69]  Anne Lynn S Chang,et al.  A case of argyria after colloidal silver ingestion , 2006, Journal of cutaneous pathology.

[70]  J. Gearhart,et al.  In vitro toxicity of nanoparticles in BRL 3A rat liver cells. , 2005, Toxicology in vitro : an international journal published in association with BIBRA.

[71]  M. Perry,et al.  Are nanoparticles potential male reproductive toxicants? A literature review , 2007 .

[72]  T. Hovig,et al.  Argyria-tissue deposition of silver as selenide. , 1981, Scandinavian journal of clinical and laboratory investigation.

[73]  S. Ghosh,et al.  Implications of silver nanoparticle induced cell apoptosis for in vitro gene therapy , 2008, Nanotechnology.

[74]  Andrew Burd,et al.  A comparative study of the cytotoxicity of silver‐based dressings in monolayer cell, tissue explant, and animal models , 2007, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[75]  Seung-Heon Shin,et al.  The effects of nano-silver on the proliferation and cytokine expression by peripheral blood mononuclear cells. , 2007, International immunopharmacology.

[76]  Lawrence E Murr,et al.  Comparative in vitro cytotoxicity assessment of some manufacturednanoparticulate materials characterized by transmissionelectron microscopy , 2005 .

[77]  G. Mostafa,et al.  Facile synthesis of silver nano particles with highly efficient anti-microbial property , 2007 .

[78]  A. Di Stefani,et al.  "Familial" generalized argyria. , 2006, Archives of dermatology.

[79]  X. Chen,et al.  Nanosilver: a nanoproduct in medical application. , 2008, Toxicology letters.

[80]  Furchner Je,et al.  Comparative metabolism of radionuclides in mammals-IV. Retention of silver-110m in the mouse, rat, monkey, and dog. , 1968 .

[81]  The metabolism of silver in the rat with radio-silver used as an indicator. , 1950, University of California publications in pharmacology.

[82]  H. Soyer,et al.  Argyria after short-contact acupuncture , 1998, The Lancet.

[83]  C. Richmond,et al.  Comparative metabolism of radionuclides in mammals-IV. Retention of silver-110m in the mouse, rat, monkey, and dog. , 1968, Health physics.

[84]  W. Aberer,et al.  A silver man , 2004, The Lancet.

[85]  C. Chou,et al.  Observation of Growth of Human Fibroblasts on Silver Nanoparticles , 2007 .

[86]  W. Shelley,et al.  Argyria: the intradermal "photograph," a manifestation of passive photosensitivity. , 1987, Journal of the American Academy of Dermatology.

[87]  Absence of symptoms in silver refiners with raised blood silver levels. , 1995, Occupational medicine.

[88]  M. Westhofen,et al.  Generalized argyrosis in man: neurotological, ultrastructural and X-ray microanalytical findings , 2004, Archives of oto-rhino-laryngology.

[89]  Jiao Sun,et al.  [A study on the bio-safety for nano-silver as anti-bacterial materials]. , 2007, Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation.

[90]  R. Prescott,et al.  Systemic argyria. , 1994, Journal of clinical pathology.

[91]  T. Flotte,et al.  Localized argyria with pseudo-ochronosis. , 2002, Journal of the American Academy of Dermatology.