Scaling mitochondrial volume in heart to body mass.

The heart mass was measured and the volume density of mitochondria, VV(mt,f), morphometrically estimated in 11 mammalian species ranging from shrew (3 g) to cattle (920 kg). The mass or the volume of the heart muscle (Vh) was found to scale as Mb0 .970 whereas VV(mt,f) scaled as Mb-0.044. Hence, the total volume of mitochondria in heart, V(mt), scaled as Mb0 .927 (V(mt) = VV(mt,f) x Vh). The volume of heart mitochondria was found to scale disproportionately to VO2max ( Mb0 .75) but in proportion to resting cardiac work rate ( Mb0 .9).

[1]  P. Anversa,et al.  Absolute morphometric study of myocardial hypertrophy in experimental hypertension. II. Ultrastructure of myocytes and interstitium. , 1978, Laboratory investigation; a journal of technical methods and pathology.

[2]  M. Kleiber Body size and metabolism , 1932 .

[3]  E. Page,et al.  Quantitative electron microscopic description of heart muscle cells. Application to normal, hypertrophied and thyroxin-stimulated hearts. , 1973, The American journal of cardiology.

[4]  G Olivetti,et al.  Morphometric Study of Early Postnatal Development in the Left and Right Ventricular Myocardium of the Rat: II. Tissue Composition, Capillary Growth, and Sarcoplasmic Alterations , 1980, Circulation research.

[5]  H. Feldman,et al.  The 3/4 mass exponent for energy metabolism is not a statistical artifact. , 1983, Respiration physiology.

[6]  E R Weibel,et al.  Design of the mammalian respiratory system. VII. Scaling mitochondrial volume in skeletal muscle to body mass. , 1981, Respiration physiology.

[7]  W. R. Stahl,et al.  Organ Weights in Primates and Other Mammals , 1965, Science.

[8]  R. Armstrong,et al.  Design of the mammalian respiratory system. VI Distribution of mitochondria and capillaries in various muscles. , 1981, Respiration physiology.

[9]  E. Page,et al.  Morphometry of rat heart mitochondrial subcompartments and membranes: application to myocardial cell atrophy after hypophysectomy. , 1976, Journal of ultrastructure research.

[10]  A C BURTON,et al.  The importance of the shape and size of the heart. , 1957, American heart journal.

[11]  W. Calder,et al.  Scaling of physiological processes in homeothermic animals. , 1981, Annual review of physiology.

[12]  W. Calder,et al.  Scaling of osmotic regulation in mammals and birds. , 1983, The American journal of physiology.

[13]  J. P. Holt,et al.  Ventricular volumes and body weight in mammals. , 1968, The American journal of physiology.

[14]  A. Keys,et al.  Density and composition of mammalian muscle , 1960 .

[15]  E R Weibel,et al.  Design of the mammalian respiratory system. III Scaling maximum aerobic capacity to body mass: wild and domestic mammals. , 1981, Respiration physiology.

[16]  A. Heusner Energy metabolism and body size. I. Is the 0.75 mass exponent of Kleiber's equation a statistical artifact? , 1982, Respiration physiology.