Sebumetric and mexametric evaluation of a fennel based cream

This study aims to investigate the effects of a topical cream (emulsion) containing 4% extract of fennel (Foeniculum vulgare) on functional skin parameters like sebum content, skin melanin, and skin erythaema, using the base without fennel as a control. Fennel extract was entrapped in the inner aqueous phase of emulsion. The creams were applied to 11 healthy male volunteers for a period of 12 weeks. Skin parameters were measured fortnightly using a Mexameter MPA 5 and a Sebumeter MPA 5 to determine the effects produced. The base showed insignificant (p > 0.05) increase while the active formulation showed significant (p 6 0.05) decrease in skin melanin and sebum content, which can be attributed to the presence of linoleic acid and oleic acids in fennel. Analysis using a paired sample t-test showed that the base decreased skin erythaema insignificantly while the formulation exerted a significant decrease indicating that it possessed anti-erythaemic effects. The formulation can therefore be used safely for the treatment of acne and as a skin whitening agent in males.

[1]  T. Mahmood,et al.  Development of a sebum control cream from a local desert plant Capparis decidua , 2012 .

[2]  T. Mahmood,et al.  Formulation development of a cream containing fennel extract: in vivo evaluation for anti-aging effects. , 2012, Die Pharmazie.

[3]  Baokang Huang,et al.  A review of chemistry and bioactivities of a medicinal spice: Foeniculum vulgare , 2011 .

[4]  T. Mahmood,et al.  Outcomes of 3% green tea emulsion on skin sebum production in male volunteers. , 2010, Bosnian journal of basic medical sciences.

[5]  M. Ichihashi,et al.  Quasi-Drugs Developed in Japan for the Prevention or Treatment of Hyperpigmentary Disorders , 2010, International journal of molecular sciences.

[6]  T. Mahmood,et al.  Formulation and evaluation of antisebum secretion effects of sea buckthorn w/o emulsion , 2010, Journal of pharmacy & bioallied sciences.

[7]  Thomas Mammone,et al.  Gender-linked differences in human skin. , 2009, Journal of dermatological science.

[8]  F. Anwar,et al.  Antioxidant and antimicrobial activities of essential oil and extracts of fennel (Foeniculum vulgare Mill.) seeds from Pakistan , 2009 .

[9]  L. Chiang,et al.  Immunomodulatory activities of common vegetables and spices of Umbelliferae and its related coumarins and flavonoids , 2008 .

[10]  Ž. Knez,et al.  Antioxidant and antimicrobial activity of guarana seed extracts , 2007 .

[11]  Huiyuan Yao,et al.  Antioxidant activities of barley seeds extracts , 2007 .

[12]  Shuxia Yang,et al.  Depigmentation of melanocytes by the treatment of extracts from traditional Chinese herbs: a cell culture assay. , 2006, Biological & pharmaceutical bulletin.

[13]  Anna Gręda,et al.  Contents of polyphenols in fruit and vegetables , 2006 .

[14]  D. Arslan,et al.  Comparative essential oil composition and antifungal effect of bitter fennel (Foeniculum vulgare ssp. piperitum) fruit oils obtained during different vegetation. , 2006, Journal of medicinal food.

[15]  Jae-Kwan Hwang,et al.  Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. , 2004, Fitoterapia.

[16]  N. Oku,et al.  Skin whitening effect of linoleic acid is enhanced by liposomal formulations. , 2004, Biological & pharmaceutical bulletin.

[17]  C. Codina,et al.  Bioguided isolation and identification of the nonvolatile antioxidant compounds from fennel (Foeniculum vulgare Mill.) waste. , 2004, Journal of agricultural and food chemistry.

[18]  N. Mimica-Dukić,et al.  Essential oil composition and antifungal activity of Foeniculum vulgare Mill. obtained by different distillation conditions , 2003, Phytotherapy research : PTR.

[19]  M. Oktay,et al.  Determination of in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts , 2003 .

[20]  K. Javidnia,et al.  Antihirsutism activity of Fennel (fruits of Foeniculum vulgare) extract. A double-blind placebo controlled study. , 2003, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[21]  V. Rogiers,et al.  The effect of two moisturisers on skin barrier damage in allergic contact dermatitis. , 2002, European journal of dermatology : EJD.

[22]  Sibel Karakaya,et al.  Antioxidant activity of some foods containing phenolic compounds. , 2001, International journal of food sciences and nutrition.

[23]  S. Bošnjak.  The declaration of Helsinki: The cornerstone of research ethics , 2001 .

[24]  Paul D. Prenzler,et al.  Phenolic compounds and their role in oxidative processes in fruits , 1999 .