Expanding the Market

Once pharmaceutical companies obtained FDA approval for their new psychiatric medications, they naturally wanted to maximize the sale of their products. This meant expanding the pool of potential patients, and to do this, the companies needed the assistance of academic psychiatry and the American Psychiatric Association (APA). From the drug companies’ perspective, the business model to be pursued was obvious: They could provide the financial resources for this task, while academic psychiatry and the APA provided the medical legitimacy. This legitimacy, industry knew, could originate with the DSM: The APA could expand the pool of potential patients by creating new diagnoses or by loosening the diagnostic criteria for existing diagnoses, and then industry could hire academic psychiatrists to conduct studies of the drugs for these new patient populations. Then industry could hire those same psychiatrists, or others in academia, as “key opinion leaders” to speak at professional conferences about the validity of the “illness” and the helpful drug treatment.

[1]  H. Akiskal The emergence of the bipolar spectrum: validation along clinical-epidemiologic and familial-genetic lines. , 2007, Psychopharmacology bulletin.

[2]  H. Möller,et al.  Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. , 2000, Journal of affective disorders.

[3]  Norma Pugh,et al.  Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial. , 2002, JAMA.

[4]  D. Stein,et al.  Consensus statement on generalized anxiety disorder from the International Consensus Group on Depression and Anxiety. , 2001, The Journal of clinical psychiatry.

[5]  J. Biederman,et al.  Attention-deficit/hyperactivity disorder: a life-span perspective. , 1998, The Journal of clinical psychiatry.

[6]  S. Faraone,et al.  Is Attention Deficit Hyperactivity Disorder Familial? , 1994, Harvard review of psychiatry.

[7]  J. Marecek Disappearances, Silences, And Anxious Rhetoric: Gender In Abnormal Psychology Textbooks , 1993 .

[8]  N. Ryan,et al.  Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial. , 2001, Journal of the American Academy of Child and Adolescent Psychiatry.

[9]  F. Goodwin,et al.  The de facto US mental and addictive disorders service system. Epidemiologic catchment area prospective 1-year prevalence rates of disorders and services. , 1993, Archives of general psychiatry.

[10]  M. Thase,et al.  The National Depressive and Manic-Depressive Association consensus statement on the undertreatment of depression. , 1997, JAMA.

[11]  E. Garland SSRI treatment for under-18s , 2004, Canadian Medical Association Journal.

[12]  David Healy One flew over the conflict of interest nest. , 2007, World psychiatry : official journal of the World Psychiatric Association.

[13]  R. Judge,et al.  Patient perspectives on once-weekly fluoxetine. , 2001, The Journal of clinical psychiatry.

[14]  M. Liebowitz,et al.  Update on the diagnosis and treatment of social anxiety disorder. , 1999, The Journal of clinical psychiatry.

[15]  G. Spielmans,et al.  From Evidence-based Medicine to Marketing-based Medicine: Evidence from Internal Industry Documents , 2010 .

[16]  M. Stein,et al.  Paroxetine treatment of generalized social phobia (social anxiety disorder): a randomized controlled trial. , 1998, JAMA.

[17]  J. Toolan Depression in children and adolescents. , 1962, The American journal of orthopsychiatry.

[18]  Michael Strand Where do classifications come from? The DSM-III, the transformation of American psychiatry, and the problem of origins in the sociology of knowledge , 2011 .

[19]  Susanna Quasem,et al.  The Loss of Sadness , 2008 .

[20]  J. Ballenger,et al.  Double-blind, fixed-dose, placebo-controlled study of paroxetine in the treatment of panic disorder. , 1998, The American journal of psychiatry.

[21]  R. Kessler,et al.  Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. , 1994, Archives of general psychiatry.

[22]  S. Ghaemi The failure to know what isn't known: negative publication bias with lamotrigine and a glimpse inside peer review , 2009, Evidence-based mental health.

[23]  Amy L. Green,et al.  Mood disorders in children and adolescents. , 2009, Journal of pediatric nursing.

[24]  J. Biederman,et al.  DSM-IV field trials for attention deficit hyperactivity disorder in children and adolescents. , 1994, The American journal of psychiatry.

[25]  Olga V. Demler,et al.  Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. , 2005, Archives of general psychiatry.

[26]  H. Akiskal The Prevalent Clinical Spectrum of Bipolar Disorders: Beyond DSM-IV , 1996, Journal of clinical psychopharmacology.

[27]  J. Biederman,et al.  Attention-deficit hyperactivity disorder and comorbid substance use disorders in adults. , 1995, Psychiatric services.

[28]  A. Rush,et al.  A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression. , 1997, Archives of general psychiatry.

[29]  M. Rynn,et al.  Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder: two randomized controlled trials. , 2003, JAMA.

[30]  Sheldon Krimsky,et al.  Financial Ties between DSM-IV Panel Members and the Pharmaceutical Industry , 2006, Psychotherapy and Psychosomatics.

[31]  R. Kessler,et al.  Mood disorders in children and adolescents: an epidemiologic perspective , 2001, Biological Psychiatry.

[32]  G. Emslie,et al.  Mood disorders in children and adolescents: psychopharmacological treatment , 2001, Biological Psychiatry.

[33]  D. Sheehan,et al.  Current concepts in the treatment of panic disorder. , 1999, The Journal of clinical psychiatry.

[34]  E. Garland Facing the evidence: antidepressant treatment in children and adolescents. , 2004, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[35]  S. Faraone,et al.  Autistic Traits in Children With and Without ADHD , 2013, Pediatrics.

[36]  Diagnosis and the DSM: A Critical Review , 2014 .

[37]  Scott B. Greenspan,et al.  Tripartite Conflicts of Interest and High Stakes Patent Extensions in the DSM-5 , 2014, Psychotherapy and Psychosomatics.

[38]  J. Stockman Lifetime Prevalence of Mental Disorders in U.S. Adolescents: Results from the National Comorbidity Survey Replication–Adolescent Supplement (NCS-A) , 2012 .

[39]  H. Akiskal,et al.  Cyclothymic disorder: validating criteria for inclusion in the bipolar affective group. , 1977, The American journal of psychiatry.

[40]  J. Leo The SSRI Trials in Children: Disturbing Implications for Academic Medicine , 2006, Ethical Human Psychology and Psychiatry.

[41]  K. Merikangas,et al.  Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication--Adolescent Supplement (NCS-A). , 2010, Journal of the American Academy of Child and Adolescent Psychiatry.

[42]  J. Gorman,et al.  Social phobia. Review of a neglected anxiety disorder. , 1985, Archives of general psychiatry.

[43]  Bremner Jd Functional neuroanatomical correlates of traumatic stress revisited 7 years later, this time with data. , 2003, Psychopharmacology bulletin.

[44]  L. Judd,et al.  The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases. , 2003, Journal of affective disorders.

[45]  Robert Michels,et al.  Issues for DSM-5: whither melancholia? The case for its classification as a distinct mood disorder. , 2010, The American journal of psychiatry.

[46]  A. Gelenberg,et al.  Trends in the use of antidepressants in a national sample of commercially insured pediatric patients, 1998 to 2002. , 2004, Psychiatric services.

[47]  Introduction. New Frontiers in the Management of Social Anxiety Disorder: Diagnosis, Treatment, and Clinical Course , 1999 .

[48]  P. Lavori,et al.  Depression in children and adolescents: new data on 'undertreatment' and a literature review on the efficacy of available treatments. , 1991, Journal of affective disorders.

[49]  J. Davidson,et al.  Posttraumatic stress disorder: epidemiology and health-related considerations. , 2000, The Journal of clinical psychiatry.

[50]  J. Davidson Treatment of posttraumatic stress disorder: the impact of paroxetine. , 2003, Psychopharmacology bulletin.

[51]  J. Biederman,et al.  Pharmacotherapy of attention-deficit hyperactivity disorder across the life cycle. , 1996, Journal of the American Academy of Child and Adolescent Psychiatry.

[52]  Emily A. Kuhl,et al.  DSM-5 field trials in the United States and Canada, Part II: test-retest reliability of selected categorical diagnoses. , 2013, The American journal of psychiatry.

[53]  S. Faraone,et al.  The naturalistic course of pharmacologic treatment of children with maniclike symptoms: a systematic chart review. , 1998, The Journal of clinical psychiatry.

[54]  A. Ravindran,et al.  Once-daily venlafaxine extended release (XR) compared with fluoxetine in outpatients with depression and anxiety. Venlafaxine XR 360 Study Group. , 1999, The Journal of clinical psychiatry.