Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson’s disease

[1]  S. Hamilton-Dutoit,et al.  Pathological α‐synuclein in gastrointestinal tissues from prodromal Parkinson disease patients , 2016, Annals of neurology.

[2]  L. Leclair-Visonneau,et al.  What a gastrointestinal biopsy can tell us about Parkinson's disease? , 2016, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[3]  G. Deuschl,et al.  Can we use peripheral tissue biopsies to diagnose Parkinson's disease? A review of the literature , 2016, European journal of neurology.

[4]  H. Reichmann,et al.  Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors , 2015, Nature Reviews Neurology.

[5]  E. Tolosa,et al.  Alpha-synuclein immunoreactivity patterns in the enteric nervous system , 2015, Neuroscience Letters.

[6]  Yun Li,et al.  Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-hydroxydopamine-induced Parkinson's disease rats. , 2015, Translational research : the journal of laboratory and clinical medicine.

[7]  K. Jellinger Neuropathobiology of non-motor symptoms in Parkinson disease , 2015, Journal of Neural Transmission.

[8]  M. Cersosimo Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson's Disease , 2015, Gastroenterology research and practice.

[9]  M. Heymann,et al.  Structural alterations of the intestinal epithelial barrier in Parkinson’s disease , 2015, Acta neuropathologica communications.

[10]  L. Hazrati,et al.  Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease , 2015, Neurology.

[11]  T. Südhof,et al.  α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation , 2014, Proceedings of the National Academy of Sciences.

[12]  J. Blaivas,et al.  A Review of Lower Urinary Tract Symptoms in Patients with Parkinson’s Disease , 2014, Current Urology Reports.

[13]  M. Catalán,et al.  In vivo gastric detection of α‐synuclein inclusions in Parkinson's disease , 2015, Movement disorders : official journal of the Movement Disorder Society.

[14]  C. Carroll,et al.  Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease , 2014, Acta Neuropathologica.

[15]  Jiajie Diao,et al.  Properties of native brain α-synuclein , 2013, Nature.

[16]  Hitoshi Takahashi,et al.  The Lewy Body in Parkinson’s Disease and Related Neurodegenerative Disorders , 2013, Molecular Neurobiology.

[17]  D. Devos,et al.  Colonic inflammation in Parkinson's disease , 2013, Neurobiology of Disease.

[18]  D. Munoz,et al.  Enteric alpha‐synuclein expression is increased in Parkinson's disease but not Alzheimer's disease , 2013, Movement disorders : official journal of the Movement Disorder Society.

[19]  G. Deuschl,et al.  Expression pattern and localization of alpha-synuclein in the human enteric nervous system , 2012, Neurobiology of Disease.

[20]  H. Reichmann,et al.  Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice , 2012, Scientific Reports.

[21]  C. Adler,et al.  Parkinson’s disease is not associated with gastrointestinal myenteric ganglion neuron loss , 2012, Acta Neuropathologica.

[22]  T. Outeiro,et al.  Alpha-synuclein: from secretion to dysfunction and death , 2012, Cell Death and Disease.

[23]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[24]  John B. Furness,et al.  The enteric nervous system and neurogastroenterology , 2012, Nature Reviews Gastroenterology &Hepatology.

[25]  H. Takayama,et al.  Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice , 2012, Laboratory Investigation.

[26]  Lisheng Li,et al.  Dopamine receptor D1 mediates the inhibition of dopamine on the distal colonic motility. , 2012, Translational research : the journal of laboratory and clinical medicine.

[27]  K. Shannon,et al.  Alpha‐synuclein in colonic submucosa in early untreated Parkinson's disease , 2012, Movement disorders : official journal of the Movement Disorder Society.

[28]  S. B. des Varannes,et al.  A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson’s disease , 2012, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[29]  O. Suchowersky,et al.  Increased Intestinal Permeability and Parkinson Disease Patients: Chicken or Egg? , 2012, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[30]  L. Stefanis α-Synuclein in Parkinson's disease. , 2012, Cold Spring Harbor perspectives in medicine.

[31]  M. Jönsson,et al.  Epithelial Expression of Vasoactive Intestinal Peptide in Ulcerative Colitis: Down-Regulation in Markedly Inflamed Colon , 2012, Digestive Diseases and Sciences.

[32]  M. Neunlist,et al.  A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease , 2012, Neurobiology of Disease.

[33]  K. Jellinger Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts , 2012, Movement disorders : official journal of the Movement Disorder Society.

[34]  Jeffrey H. Kordower,et al.  Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease , 2011, PloS one.

[35]  K. Lyons,et al.  The impact and management of nonmotor symptoms of Parkinson's disease. , 2011, The American journal of managed care.

[36]  K. Krogh Gastrointestinal Dysfunction in Parkinson’s Disease , 2011 .

[37]  D. Selkoe,et al.  α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation , 2011, Nature.

[38]  M. Gershon Developmental determinants of the independence and complexity of the enteric nervous system , 2010, Trends in Neurosciences.

[39]  P. Damier,et al.  Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms , 2010, PloS one.

[40]  W. Meier-Ruge,et al.  The London Classification of gastrointestinal neuromuscular pathology: report on behalf of the Gastro 2009 International Working Group , 2010, Gut.

[41]  Johannes C. Klein,et al.  Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo , 2010, Neurology.

[42]  H. Reichmann,et al.  Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice , 2010, PloS one.

[43]  E. Bézard,et al.  Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms , 2009, The Lancet Neurology.

[44]  Thomas Gasser,et al.  Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria , 2009, The Lancet Neurology.

[45]  S. B. des Varannes,et al.  Routine colonic biopsies as a new tool to study the enteric nervous system in living patients , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[46]  Takuya Suzuki,et al.  PKCη regulates occludin phosphorylation and epithelial tight junction integrity , 2009, Proceedings of the National Academy of Sciences.

[47]  P. Damier,et al.  Pathological lesions in colonic biopsies during Parkinson’s disease , 2008, Gut.

[48]  C. Adler,et al.  Evaluation of α-synuclein immunohistochemical methods used by invited experts , 2008, Acta Neuropathologica.

[49]  T. Powley,et al.  Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease? , 2008, Neuroscience.

[50]  J. Furness,et al.  The enteric nervous system: normal functions and enteric neuropathies , 2008, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[51]  J. Jankovic,et al.  Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Process, format, and clinimetric testing plan , 2007, Movement disorders : official journal of the Movement Disorder Society.

[52]  M. Perdue,et al.  Muscarinic acetylcholine receptor activation increases transcellular transport of macromolecules across mouse and human intestinal epithelium in vitro , 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[53]  R. Barbour,et al.  Phosphorylation of Ser-129 Is the Dominant Pathological Modification of α-Synuclein in Familial and Sporadic Lewy Body Disease* , 2006, Journal of Biological Chemistry.

[54]  R. Nussbaum,et al.  Levels of alpha‐synuclein mRNA in sporadic Parkinson disease patients , 2006, Movement disorders : official journal of the Movement Disorder Society.

[55]  Jochen Klucken,et al.  Detection of novel intracellular O‐synuclein oligomeric species by fluorescence lifetime imaging , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[56]  A. Probst,et al.  α‐Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects , 2006, Neuropathology and applied neurobiology.

[57]  H. Braak,et al.  Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology , 2006, Neuroscience Letters.

[58]  C. Shults Lewy bodies. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[59]  Yi Zhao,et al.  Alpha‐synuclein mRNA expression in sporadic Parkinson's disease , 2005, Movement disorders : official journal of the Movement Disorder Society.

[60]  M. Neunlist,et al.  The human enteric nervous system , 2004, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[61]  A. Lees,et al.  Alteration in α‐synuclein mRNA expression in Parkinson's disease , 2004 .

[62]  K. Murthy,et al.  Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptors. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[63]  A. Fasano,et al.  Gastrointestinal dysfunction in Parkinson's disease , 2003, The Lancet Neurology.

[64]  S. Hirai,et al.  Heterogeneity of Nigral and Cortical Lewy Bodies Differentiated by Amplified Triple-Labeling for Alpha-Synuclein, Ubiquitin, and Thiazin Red , 2002, Experimental Neurology.

[65]  T. Chase,et al.  Muscarinic Receptor Stimulation Induces Translocation of an α-Synuclein Oligomer from Plasma Membrane to a Light Vesicle Fraction in Cytoplasm* , 2001, The Journal of Biological Chemistry.

[66]  S. Brookes,et al.  Anatomy and physiology of the enteric nervous system , 2000, Gut.

[67]  B. Hyman,et al.  α-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining , 2000, Acta Neuropathologica.

[68]  P. Andrews,et al.  Fundamentals of neurogastroenterology , 1999, Gut.

[69]  W. Kühnel,et al.  Organization of the enteric nervous system in the human colon demonstrated by wholemount immunohistochemistry with special reference to the submucous plexus. , 1999, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.

[70]  S. Wexner,et al.  A constipation scoring system to simplify evaluation and management of constipated patients , 1996, Diseases of the colon and rectum.

[71]  G. Burnstock,et al.  Vasoactive intestinal polypeptide levels in sigmoid colon in idiopathic constipation and diverticular disease. , 1990, Gastroenterology.

[72]  Xiao-ying Jiang,et al.  Effects of enteral nutrition on the barrier function of the intestinal mucosa and dopamine receptor expression in rats with traumatic brain injury. , 2015, JPEN. Journal of parenteral and enteral nutrition.

[73]  J. Woulfe,et al.  Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease. , 2015, Neurology.

[74]  J. Dorszewska,et al.  [Alpha-synuclein in Parkinson's disease]. , 2014, Przeglad lekarski.

[75]  Jing-Jing Wei,et al.  The 5-HT4 receptor agonist mosapride attenuates inflammation of reflux esophagitis. , 2014, Hepato-Gastroenterology.

[76]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[77]  M. Matsui,et al.  M2 and M3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: Findings obtained with muscarinic-receptor knockout mouse. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[78]  A. Lees,et al.  Alteration in alpha-synuclein mRNA expression in Parkinson's disease. , 2004, Movement disorders : official journal of the Movement Disorder Society.

[79]  S. Holm A Simple Sequentially Rejective Multiple Test Procedure , 1979 .