Synthesis of N-functionalized 2,3-disubstituted benzofurans/naphthofurans from para-quinone methides and isocyanides via the [4 + 1] annulation pathway

Synthesis of 2-amino substituted benzo- and naphtho-furans via [4 + 1] cycloaddition of 2-hydroxy-substituted p-QMs and various alkyl/aryl isocyanides has been achieved by using Sc(OTf)3 as the catalyst.

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