Menthol-Activated Cells in the Reward-Addiction Neurocircuitry

Background: Menthol, a commonly used flavoring additive in cigarettes has been found to facilitate smoking initiation and nicotine addiction. However, the neuroanatomical and neurochemical targets of menthol within the reward-addiction neurocircuitry remain unknown. In the present study in mice, we hypothesized that dopaminergic and GABAergic neurons of the reward-addiction circuitry are among the initial targets of menthol in the CNS.

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