Abnormal dopaminergic modulation of striato-cortical networks underlies levodopa-induced dyskinesias in humans

Abnormal dopaminergic modulation of connectivity between the putamen and cortex is thought to underlie the emergence of levodopa-induced dyskinesias. Herz et al. confirm this directly by showing that in individuals with Parkinson's disease who have taken a single dose of levodopa, changes in connectivity preceding dyskinesias accurately predict their severity.

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