Preoperative glucose in surgical oncology patient is not associated with postoperative outcomes after adjustment for frailty

Observational studies have shown associations between even small elevations in preoperative glucose and poorer outcomes, including increased length of stay (LOS) and higher mortality. This has led to calls for aggressive glycemic control in the preoperative period, including delay of treatment until glucose is reduced. However, it is not known whether there is a direct causal effect of blood glucose or whether adverse outcomes result from overall poorer health in patients with higher glucose.

[1]  E. Huang,et al.  16. Diabetes Care in the Hospital: Standards of Medical Care in Diabetes-2022. , 2021, Diabetes care.

[2]  Yu-Chun Wang,et al.  Association Between Preoperative Blood Glucose Level and Hospital Length of Stay for Patients Undergoing Appendectomy or Laparoscopic Cholecystectomy , 2020, Diabetes care.

[3]  Kyunga Kim,et al.  Associations Between Preoperative Glucose and Hemoglobin A1c Level and Myocardial Injury After Noncardiac Surgery , 2020, Journal of the American Heart Association.

[4]  A. Vickers,et al.  Development and Evaluation of a New Frailty Index for Older Surgical Patients With Cancer , 2019, JAMA network open.

[5]  Zhou Kang,et al.  Effects of perioperative tight glycemic control on postoperative outcomes: a meta-analysis , 2018, Endocrine connections.

[6]  Susan E. Spratt,et al.  Rationalization, Development, and Implementation of a Preoperative Diabetes Optimization Program Designed to Improve Perioperative Outcomes and Reduce Cost , 2017, Diabetes Spectrum.

[7]  A. Bader,et al.  Effect of Preoperative Diabetes Management on Glycemic Control and Clinical Outcomes After Elective Surgery , 2017, Annals of surgery.

[8]  S. Surani,et al.  Guidelines for Perioperative Management of the Diabetic Patient , 2015, Surgery research and practice.

[9]  K. Dhatariya.  Comment on Underwood et al. Preoperative A1C and Clinical Outcomes in Patients With Diabetes Undergoing Major Noncardiac Surgical Procedures. Diabetes Care 2014;37:611–616 , 2014, Diabetes Care.

[10]  R. Garg,et al.  Response to Comment on Underwood et al. Preoperative A1C and Clinical Outcomes in Patients With Diabetes Undergoing Major Noncardiac Surgical Procedures. Diabetes Care 2014;37:611–616 , 2014, Diabetes Care.

[11]  R. Garg,et al.  Preoperative A1C and Clinical Outcomes in Patients With Diabetes Undergoing Major Noncardiac Surgical Procedures , 2014, Diabetes Care.

[12]  Seung-Baik Kang,et al.  Relations between Long-term Glycemic Control and Postoperative Wound and Infectious Complications after Total Knee Arthroplasty in Type 2 Diabetics , 2013, Clinics in orthopedic surgery.

[13]  A. Khwaja.  KDIGO Clinical Practice Guidelines for Acute Kidney Injury , 2012, Nephron Clinical Practice.

[14]  G. Umpierrez,et al.  Glycemic control in non-diabetic critically ill patients. , 2011, Best practice & research. Clinical endocrinology & metabolism.

[15]  Limin Peng,et al.  Randomized Study of Basal-Bolus Insulin Therapy in the Inpatient Management of Patients With Type 2 Diabetes Undergoing General Surgery (RABBIT 2 Surgery) , 2011, Diabetes Care.

[16]  G. Umpierrez,et al.  Prevalence and Clinical Outcome of Hyperglycemia in the Perioperative Period in Noncardiac Surgery , 2010, Diabetes Care.

[17]  J. Avorn,et al.  High-dimensional Propensity Score Adjustment in Studies of Treatment Effects Using Health Care Claims Data , 2009, Epidemiology.

[18]  R. Guyton,et al.  Elevated preoperative hemoglobin A1c level is predictive of adverse events after coronary artery bypass surgery. , 2008, The Journal of thoracic and cardiovascular surgery.

[19]  J. Concato,et al.  Long-term glycemic control and postoperative infectious complications. , 2006, Archives of surgery.

[20]  Kosuke Imai,et al.  Causal Inference With General Treatment Regimes , 2004 .

[21]  N. Demartines,et al.  Classification of Surgical Complications: A New Proposal With Evaluation in a Cohort of 6336 Patients and Results of a Survey , 2004, Annals of Surgery.

[22]  M. Cakir,et al.  Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. , 2003, The Journal of clinical endocrinology and metabolism.

[23]  David R Flum,et al.  Perioperative hyperglycemia and risk of adverse events among patients with and without diabetes. , 2015, Annals of surgery.

[24]  G. Van den Berghe,et al.  Preoperative blood glucose concentrations and postoperative outcomes after elective non-cardiac surgery: an observational study. , 2014, British journal of anaesthesia.

[25]  Jeroen J. Bax,et al.  Increased preoperative glucose levels are associated with perioperative mortality in patients undergoing noncardiac, nonvascular surgery. , 2007, European journal of endocrinology.