Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia

Glutamate decarboxylase (GAD) activity was measured in the nuclei of the basal ganglia in patients with neuroleptic‐induced tardive dyskinesia (TD) and controls matched for age and premortem state. In five TD patients, who all had a sudden death, a significant decrease in GAD activity was found in the subthalamic nucleus (STN). The lowered GAD activity in the STN may represent a biochemical substrate for neuroleptic‐induced TD.

[1]  Y. Agid,et al.  Brain glutamate decarboxylase in Parkinson's disease with particular reference to a premortem severity index. , 1985, Brain : a journal of neurology.

[2]  M. D. Crutcher,et al.  Primate globus pallidus and subthalamic nucleus: functional organization. , 1985, Journal of neurophysiology.

[3]  M. Sambrook,et al.  Experimental hemichorea/hemiballismus in the monkey. Studies on the intracerebral site of action in a drug-induced dyskinesia. , 1984, Brain : a journal of neurology.

[4]  L. Gunne,et al.  Association with persistent neuroleptic-induced dyskinesia of regional changes in brain GABA synthesis , 1984, Nature.

[5]  E K Perry,et al.  Human brain neurochemistry - some postmortem problems. , 1983, Life sciences.

[6]  Robert M. Beckstead,et al.  A reciprocal axonal connection between the subthalamic nucleus and the neostriatum in the cat , 1983, Brain Research.

[7]  E. Perry,et al.  The influence of agonal status on some neurochemical activities of postmortem human brain tissue , 1982, Neuroscience Letters.

[8]  J. Kane,et al.  Research diagnoses for tardive dyskinesia. , 1982, Archives of general psychiatry.

[9]  J. Kane,et al.  Tardive dyskinesia: prevalence and risk factors, 1959 to 1979 , 1982, Archives of general psychiatry.

[10]  T. Perry,et al.  Postmortem Changes of Amino Compounds in Human and Rat Brain , 1981, Journal of neurochemistry.

[11]  M. Sambrook,et al.  Experimental hemiballismus in the baboon produced by injection of a gamma-aminobutyric acid antagonist into the basal ganglia , 1980, Neuroscience Letters.

[12]  T. Hattori,et al.  Single subthalamic nucleus neurons project to both the globus pallidus and substantia nigra in rat , 1980, The Journal of comparative neurology.

[13]  E. Spokes.  An analysis of factors influencing measurements of dopamine, noradrenaline, glutamate decarboxylase and choline acetylase in human post-mortem brain tissue. , 1979, Brain : a journal of neurology.

[14]  P. Gaspar,et al.  POST MORTEM STABILITY AND STORAGE IN THE COLD OF BRAIN ENZYMES , 1979, Journal of neurochemistry.

[15]  D M Bowen,et al.  Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. , 1976, Brain : a journal of neurology.

[16]  K. F. Schroeder,et al.  Morphometric studies of the neuropathological changes in choreatic diseases , 1976, Journal of the Neurological Sciences.

[17]  L. Cote,et al.  STABILITY OF ENZYMES IN POST‐MORTEM RAT BRAIN 1 , 1976, Journal of neurochemistry.

[18]  H. Klawans.  The pharmacology of tardive dyskinesias. , 1973, The American journal of psychiatry.

[19]  M. Carpenter,et al.  Analysis of somatotopic relations of the corpus Luysi in man and monkey. Relation between the site of dyskinesia and distribution of lesions within the subthalamic nucleus , 1951, The Journal of comparative neurology.

[20]  J. Whittier.  BALLISM AND THE SUBTHALAMIC NUCLEUS (NUCLEUS HYPOTHALAMICUS; CORPUS LUYSI): Review of the Literature and Study of Thirty Cases , 1947 .