Ergothioneine; antioxidant potential, physiological function and role in disease.

[1]  A. Norins Free radical formation in the skin following exposure to ultraviolet light. , 1962, The Journal of investigative dermatology.

[2]  B. Halliwell,et al.  Using isoprostanes as biomarkers of oxidative stress: some rarely considered issues. , 2010, Antioxidants & redox signaling.

[3]  R. Fraser Blood ergothioneine levels in disease. , 1951, The Journal of laboratory and clinical medicine.

[4]  R. J. Cersosimo,et al.  Cisplatin neurotoxicity. , 1989, Cancer treatment reviews.

[5]  J. M. May,et al.  Uptake and antioxidant effects of ergothioneine in human erythrocytes. , 1999, Clinical science.

[6]  L. Jen,et al.  Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death. , 2004, Free radical biology & medicine.

[7]  K. Delank,et al.  Association of rheumatoid arthritis with ergothioneine levels in red blood cells: a case control study. , 2006, The Journal of rheumatology.

[8]  '. C.M.CASTLEDEN THE EFFECT OF AGE ON PLASMA LEVELS OF PROPRANOLOL AND PRACTOLOL IN MAN , 2006 .

[9]  Y. Sugiura,et al.  Metal Complexes of Ergothioneine , 1974 .

[10]  A. Rubbert,et al.  Functional role of the 503F variant of the organic cation transporter OCTN1 in Crohn’s disease , 2005, Gut.

[11]  Y. Sugiura,et al.  Radioprotective effect of ergothioneine on gamma-irradiation of metmyoglobin: comparison with cysteine on sulfmyoglobin-formation. , 1977, Chemical & pharmaceutical bulletin.

[12]  B. A. Eagles,et al.  THE ISOLATION FROM BLOOD OF A HITHERTO UNKNOWN SUBSTANCE, AND ITS BEARING ON PRESENT METHODS FOR THE ESTIMATION OF URIC ACID , 1925 .

[13]  B. Halliwell,et al.  Antioxidant action of ergothioneine: assessment of its ability to scavenge peroxynitrite. , 1997, Biochemical and biophysical research communications.

[14]  E. Land,et al.  One-electron oxidation of ergothioneine and analogues investigated by pulse radiolysis: redox reaction involving ergothioneine and vitamin C. , 1996, The Biochemical journal.

[15]  E. Mussini,et al.  Determination of ergothioneine in red blood cells by high-performance liquid chromatography. , 1988, Journal of chromatography.

[16]  T. Merriman,et al.  Polymorphisms in the organic cation transporter genes SLC22A4 and SLC22A5 and Crohn's disease in a New Zealand Caucasian cohort , 2006, Immunology and cell biology.

[17]  N. Venketasubramanian,et al.  Oxidative Damage in Ischemic Stroke Revealed Using Multiple Biomarkers , 2011, Stroke.

[18]  E. Land,et al.  DEACTIVATION OF SINGLET MOLECULAR OXYGEN BY THIOLS AND RELATED COMPOUNDS, POSSIBLE PROTECTORS AGAINST SKIN PHOTOSENSITIVITY , 1988, Photochemistry and photobiology.

[19]  Carl W. Cotman,et al.  In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity , 1991, Brain Research.

[20]  C. Rimington,et al.  Some effects of administering ergothioneine to rats. , 1952, The Biochemical journal.

[21]  R. Klevit,et al.  Ovothiol: a novel thiohistidine compound from sea urchin eggs that confers NAD(P)H-O2 oxidoreductase activity on ovoperoxidase. , 1986, The Journal of biological chemistry.

[22]  B. Freeman,et al.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[23]  W. H. Horner,et al.  Tissue ergothioneine. , 1954, The Journal of biological chemistry.

[24]  P. Libby,et al.  Progress and challenges in translating the biology of atherosclerosis , 2011, Nature.

[25]  Y. Kawai,et al.  Studies on ergothioneine. VI. Distribution and fluctuations of ergothioneine in rats. , 1982, Chemical & pharmaceutical bulletin.

[26]  G. Woodruff,et al.  The presence of ergothioneine in the central nervous system and its probable identity with the cerebellar factor , 1966, The Journal of physiology.

[27]  B. Halliwell The wanderings of a free radical. , 2009, Free radical biology & medicine.

[28]  R. Kerber,et al.  Transition metal chelators reduce directly measured myocardial free radical production during reperfusion. , 1998, Journal of cardiovascular pharmacology.

[29]  D. Royse,et al.  Identification and Quantification of Ergothioneine in Cultivated Mushrooms by Liquid Chromatography-Mass Spectroscopy , 2006 .

[30]  H. Ou,et al.  Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[31]  K. Aigner,et al.  Peripheral nerve damage following isolated extremity perfusion with cis-platinum. , 1983, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[32]  O. Aruoma,et al.  Effects of ergothioneine on diabetic embryopathy in pregnant rats. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[33]  Bill Newman,et al.  Functional variants of OCTN cation transporter genes are associated with Crohn disease , 2004, Nature Genetics.

[34]  Yusuke Nakamura,et al.  An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis , 2003, Nature Genetics.

[35]  T. Ohshima,et al.  Antioxidative activity and antidiscoloration efficacy of ergothioneine in mushroom (Flammulina velutipes) extract added to beef and fish meats. , 2008, Journal of agricultural and food chemistry.

[36]  S. Golz,et al.  Discovery of the ergothioneine transporter. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[37]  T. Mann,et al.  Studies on the metabolism of semen. VIII. Ergothioneine as a normal constituent of boar seminal plasma; purification and crystallization; site of formation and function. , 1953, The Biochemical journal.

[38]  D. Yarosh,et al.  A comparison of the relative antioxidant potency of L‐ergothioneine and idebenone , 2007, Journal of cosmetic dermatology.

[39]  P. Jocelyn Biochemistry of the SH group , 1972 .

[40]  J. Spencer,et al.  Protection against oxidative damage and cell death by the natural antioxidant ergothioneine. , 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[41]  E. Schömig,et al.  Dietary sources and antioxidant effects of ergothioneine. , 2007, Journal of agricultural and food chemistry.

[42]  H. Salt The ergothioneine content of the blood in health and disease. , 1931, The Biochemical journal.

[43]  D. B. Melville,et al.  On the origin of animal ergothioneine. , 1955, The Journal of biological chemistry.

[44]  L. Migliore,et al.  An in vitro study on the free radical scavenging capacity of ergothioneine: comparison with reduced glutathione, uric acid and trolox. , 2006, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[45]  S. Snyder,et al.  The unusual amino acid L-ergothioneine is a physiologic cytoprotectant , 2010, Cell Death and Differentiation.

[46]  V. Ganapathy,et al.  Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. , 2000, Biochimica et biophysica acta.

[47]  R. Ferrari,et al.  In vitro administration of ergothioneine failed to protect isolated ischaemic and reperfused rabbit heart. , 1995, Biochimica et biophysica acta.

[48]  D. Hanlon Interaction of ergothioneine with metal ions and metalloenzymes. , 1971, Journal of medicinal chemistry.

[49]  E. Tsimoyiannis,et al.  Oxygen-derived free radicals in hepatic ischemia and reperfusion injury in the rat. , 1990, Surgery, gynecology & obstetrics.

[50]  T. Kumosani L-ergothioneine level in red blood cells of healthy human males in the Western province of Saudi Arabia , 2001, Experimental & Molecular Medicine.

[51]  Catalina Carrasco-Pozo,et al.  Cu(I)-glutathione complex: a potential source of superoxide radicals generation. , 2008, Bioorganic & medicinal chemistry.

[52]  A. L. Latner A colorimetric method for the estimation of ergothioneine in human blood. , 1948, The Biochemical journal.

[53]  A. Lamhonwah,et al.  Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria. , 2006, Biochemical and biophysical research communications.

[54]  S. Aizawa,et al.  Expression of organic cation transporter OCTN1 in hematopoietic cells during erythroid differentiation. , 2004, Experimental hematology.

[55]  K. Tomita,et al.  Estimation of ergothioneine in urine, blood and organs by determination of the alkaline perhydrol-labile sulfur. , 1952, Japanese journal of medical science & biology.

[56]  C. Rimington,et al.  Synthesis of Ergothioneine , 1950, Nature.

[57]  Wolfram Klitzsch [K] , 1962, Dendara. Catalogue des dieux et des offrandes.

[58]  B. Kalyanaraman,et al.  Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex. , 2011, Chemical research in toxicology.

[59]  E. Schömig,et al.  Increased ergothioneine tissue concentrations in carriers of the Crohn’s disease risk-associated 503F variant of the organic cation transporter OCTN1 , 2009, Gut.

[60]  J. Carlsson,et al.  A convenient spectrophotometric assay for the determination of L-ergothioneine in blood. , 1974, The Biochemical journal.

[61]  Beatty Ch Levels of ergothioneine in the red blood cell in experimental diabetes. , 1952 .

[62]  I. Rahman,et al.  Ergothioneine inhibits oxidative stress- and TNF-α-induced NF-κB activation and interleukin-8 release in alveolar epithelial cells , 2003 .

[63]  L. Jen,et al.  Ergothioneine treatment protects neurons against N-methyl-d-aspartate excitotoxicity in an in vivo rat retinal model , 2002, Neuroscience Letters.

[64]  C. Rimington,et al.  Studies using radioactive sulphur on ergothioneine formation in the pig. , 1953, The Biochemical journal.

[65]  R. Hayeshi,et al.  The interaction of selected natural products with human recombinant glutathione transferases , 2004, Phytotherapy research : PTR.

[66]  K. Martin The bioactive agent ergothioneine, a key component of dietary mushrooms, inhibits monocyte binding to endothelial cells characteristic of early cardiovascular disease. , 2010, Journal of medicinal food.

[67]  J. Pulido,et al.  Ergothioneine distribution in bovine and porcine ocular tissues. , 1997, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

[68]  O. Cinek,et al.  Two independent genetic factors responsible for the associations of the IBD5 locus with Crohn's disease in the Czech population , 2011, Inflammatory bowel diseases.

[69]  G. Hunter A new test for ergothioneine upon which is based a method for its estimation in simple solution and in blood-filtrates. , 1928, The Biochemical journal.

[70]  Y. Sugiura,et al.  Complexing of copper ion by ergothioneine. , 1976, Chemical & pharmaceutical bulletin.

[71]  T. Mayumi,et al.  Studies on ergothioneine. VII. Some effects on ergothioneine on glycolytic metabolism in red blood cells from rats. , 1982, Chemical & pharmaceutical bulletin.

[72]  J. A. Behre,et al.  THE OCCURRENCE AND DETERMINATION OF THIONEINE (ERGOTHIONEINE) IN HUMAN BLOOD , 1929 .

[73]  A. Bedirli,et al.  Ergothioneine modulates proinflammatory cytokines and heat shock protein 70 in mesenteric ischemia and reperfusion injury. , 2008, The Journal of surgical research.

[74]  B. Halliwell,et al.  Allantoin in human plasma, serum, and nasal-lining fluids as a biomarker of oxidative stress: avoiding artifacts and establishing real in vivo concentrations. , 2009, Antioxidants & redox signaling.

[75]  K. Siminovitch,et al.  SLC22A4 polymorphisms implicated in rheumatoid arthritis and Crohn's disease are not associated with rheumatoid arthritis in a Canadian Caucasian population. , 2005, Arthritis and rheumatism.

[76]  G. Toennies,et al.  The preparation and properties of ergothioneine disulphide. , 1958, The Biochemical journal.

[77]  B. Halliwell,et al.  Free radicals in biology and medicine , 1985 .

[78]  P. Jocelyn Biochemistry of the SH group : the occurrence, chemical properties, metabolism and biological function of thiols and disulphides , 1972 .

[79]  H. Heath,et al.  The biosynthesis of ergothioneine and histidine by Claviceps purpurea. I. The incorporation of [2-14C]acetate. , 1956, The Biochemical journal.

[80]  Linda Partridge,et al.  Unraveling the biological roles of reactive oxygen species. , 2011, Cell metabolism.

[81]  B. A. Eagles,et al.  THE PHYSIOLOGY OF ERGOTHIONEINE , 1928 .

[82]  O. Touster Estimation of blood ergothioneine by determination of brominelabile sulfur. , 1951, The Journal of biological chemistry.

[83]  S. Jegard,et al.  Blood ergothioneine levels in diabetes mellitus. , 1950, The Journal of laboratory and clinical medicine.

[84]  N. Motohashi,et al.  Thiol-induced hydroxyl radical formation and scavenger effect of thiocarbamides on hydroxyl radicals. , 1986, Journal of inorganic biochemistry.

[85]  C. Triggs,et al.  Mushroom intolerance: a novel diet–gene interaction in Crohn's disease , 2009, British Journal of Nutrition.

[86]  A. Arduini,et al.  The reduction of ferryl myoglobin by ergothioneine: a novel function for ergothioneine. , 1990, Archives of biochemistry and biophysics.

[87]  I. Rahman,et al.  Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells. , 2003, Biochemical and biophysical research communications.

[88]  J. Bockaert,et al.  NMDA-dependent superoxide production and neurotoxicity , 1993, Nature.

[89]  T. Mayumi,et al.  Studies on ergothioneine. XI. Inhibitory effect on lipid peroxide formation in mouse liver. , 1983, Chemical & pharmaceutical bulletin.

[90]  H P Misra,et al.  Generation of superoxide free radical during the autoxidation of thiols. , 1974, The Journal of biological chemistry.

[91]  M. Brummel In search of a physiological function for L-ergothioneine--II. , 1985, Medical hypotheses.

[92]  T. Ohshima,et al.  Effects of ergothioneine from mushrooms (Flammulina velutipes) on melanosis and lipid oxidation of kuruma shrimp (Marsupenaeus japonicus). , 2010, Journal of agricultural and food chemistry.

[93]  G. Duménil,et al.  Evaluation of photolyase (Photosome) repair activity in human keratinocytes after a single dose of ultraviolet B irradiation using the comet assay. , 2005, Journal of photochemistry and photobiology. B, Biology.

[94]  E. Bruckert,et al.  Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. , 2002, The Journal of clinical endocrinology and metabolism.

[95]  C. H. Beatty Levels of ergothioneine in the red blood cell in experimental diabetes. , 1952, The Journal of biological chemistry.

[96]  D. Butterfield,et al.  In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42) , 1999, Neurobiology of aging.

[97]  T. Mayumi,et al.  Quantitative determination of ergothioneine in plasma and tissues by TLC-densitometry. , 1980, Chemical & pharmaceutical bulletin.

[98]  E. Stadtman,et al.  Human studies related to protein oxidation: protein carbonyl content as a marker of damage. , 2000, Free radical research.

[99]  V. M. Mendoza-Núñez,et al.  Aging-related oxidative stress in healthy humans. , 2007, The Tohoku journal of experimental medicine.

[100]  D. Yarosh,et al.  L-Ergothioneine scavenges superoxide and singlet oxygen and suppresses TNF-alpha and MMP-1 expression in UV-irradiated human dermal fibroblasts. , 2005, Journal of cosmetic science.

[101]  T. Mann Studies on the metabolism of semen. 7. Cytochrome in human spermatozoa. , 1951, The Biochemical journal.

[102]  D. Yarosh,et al.  Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system. , 2009, Free radical biology & medicine.

[103]  B. Halliwell,et al.  Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. , 2008, Free radical biology & medicine.

[104]  P. Zheng,et al.  SLC22A4 and SLC22A5 gene polymorphisms and Crohn's disease in the Chinese Han population , 2009, Journal of digestive diseases.

[105]  P. Hartman Ergothioneine as antioxidant. , 1990, Methods in enzymology.

[106]  L. Migliore,et al.  Modulation of palmitic acid‐induced cell death by ergothioneine: Evidence of an anti‐inflammatory action , 2008, BioFactors.

[107]  C. Di Giorgio,et al.  Genotoxicity of visible light (400-800 nm) and photoprotection assessment of ectoin, L-ergothioneine and mannitol and four sunscreens. , 2008, Journal of photochemistry and photobiology. B, Biology.

[108]  M. Tomita,et al.  Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1 , 2010, Pharmaceutical Research.

[109]  H. Heath,et al.  Biosynthesis of Ergothioneine , 1957, Nature.

[110]  G. Gores,et al.  The Role of Metals in Ischemia/Reperfusion Injury of the Liver , 1996, Seminars in liver disease.

[111]  K. Miyazawa,et al.  Mechanism of the Regulation of Organic Cation/Carnitine Transporter 1 (SLC22A4) by Rheumatoid Arthritis-Associated Transcriptional Factor RUNX1 and Inflammatory Cytokines , 2007, Drug Metabolism and Disposition.

[112]  Xiang Gao,et al.  OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease. , 2008, World journal of gastroenterology.

[113]  I. Tamai,et al.  Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4). , 2008, Biological & pharmaceutical bulletin.

[114]  J. Carlsson,et al.  Reactions of L-ergothioneine and some other aminothiones with2,2'-and 4,4'-dipyridyl disulphides and of L-ergothioneine with iodoacetamide. 2-Mercaptoimidazoles, 2- and 4-thiopyridones, thiourea and thioacetamide as highly reactive neutral sulphur nucleophils. , 1974, The Biochemical journal.

[115]  G. Newton,et al.  Analysis of biological thiols: quantitative determination of thiols at the picomole level based upon derivatization with monobromobimanes and separation by cation-exchange chromatography. , 1981, Analytical biochemistry.

[116]  G. Newton,et al.  Organic Hydroperoxide Resistance Protein and Ergothioneine Compensate for Loss of Mycothiol in Mycobacterium smegmatis Mutants , 2011, Journal of bacteriology.

[117]  H. V. Morley,et al.  The determination of ergothioneine; the non-occurrence of ergothioneine in urine. , 1950, The Biochemical journal.

[118]  K. Kalimeris,et al.  Iron Chelation for Amelioration of Liver Ischemia-Reperfusion Injury , 2010, Hemoglobin.

[119]  W. Smith,et al.  Spin‐echo 1H NMR detected response of ergothioneine to oxidative stress in the intact human erythrocyte , 1988, Magnetic resonance in medicine.

[120]  B. Halliwell,et al.  Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? , 2004, British journal of pharmacology.

[121]  H. Dakin,et al.  ON THIASINE, ITS STRUCTURE AND IDENTIFICATION WITH ERGOTHIONEINE , 1927 .

[122]  M. Citardi,et al.  Ergothioneine, histidine, and two naturally occurring histidine dipeptides as radioprotectors against gamma-irradiation inactivation of bacteriophages T4 and P22. , 1988, Radiation research.

[123]  Y. Sugiura,et al.  Effect of Ergothioneine on γ-Irradiation of Metmyoglobin , 1973 .

[124]  L. Jen,et al.  Ergothioneine rescues PC12 cells from β-amyloid-induced apoptotic death ☆ , 2004 .

[125]  T. Ozben,et al.  Alterations of antioxidant enzymes and oxidative stress markers in aging , 2001, Experimental Gerontology.

[126]  I. Briggs ERGOTHIONEINE IN THE CENTRAL NERVOUS SYSTEM , 1972, Journal of neurochemistry.

[127]  C. Tanret Sur une base nouvelle retiree du seigle ergote, l'ergothioneine , 1909 .

[128]  C. Mackenzie,et al.  The effect of age, sex, and androgen on blood ergothioneine. , 1957, The Journal of biological chemistry.

[129]  A. Bedirli,et al.  Ergothioneine pretreatment protects the liver from ischemia-reperfusion injury caused by increasing hepatic heat shock protein 70. , 2004, The Journal of surgical research.

[130]  D. B. Melville,et al.  Ergothioneine in microorganisms. , 1956, The Journal of biological chemistry.

[131]  S. Aizawa,et al.  Decreased Proliferation and Erythroid Differentiation of K562 Cells by siRNA-induced Depression of OCTN1 (SLC22A4) Transporter Gene , 2007, Pharmaceutical Research.

[132]  D. S. Genghof,et al.  BIOSYNTHESIS OF ERGOTHIONEINE AND HERCYNINE BY MYCOBACTERIA , 1964, Journal of bacteriology.

[133]  L. Greene,et al.  Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[134]  E. Lee,et al.  Genetic variations of the SLC22A5 gene in the Chinese and Indian populations of Singapore. , 2010, Drug metabolism and pharmacokinetics.

[135]  P. Hartman [32] Ergothioneine as antioxidant , 1990 .

[136]  D. B. Melville,et al.  A method for the determination of ergothioneine in blood. , 1953, The Journal of biological chemistry.

[137]  K. Köhrer,et al.  Oligonucleotide microarray analysis of differential transporter regulation in the regenerating rat liver , 2005, Liver international : official journal of the International Association for the Study of the Liver.

[138]  B. Halliwell,et al.  Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? , 2011, Free radical biology & medicine.

[139]  Célio X. C. Santos,et al.  Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology. , 2002, Free radical biology & medicine.

[140]  J. Yadan,et al.  Synthesis of L-(+)-Ergothioneine. , 1996 .

[141]  Wi-Young Lee,et al.  Ergothioneine accumulation in a medicinal plant Gastrodia elata. , 2010 .

[142]  Latner Al A colorimetric method for the estimation of ergothioneine in human blood. , 1948 .

[143]  S. Spicer,et al.  Ergothioneine Depletion in Rabbit Erythrocytes and Its Effect on Methemoglobin Formation and Reversion , 1951, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[144]  Y. Kawai,et al.  Studies on ergothioneine. V. Determination by high performance liquid chromatography and application to metabolic research. , 1978, Chemical & pharmaceutical bulletin.

[145]  S. Taylor,et al.  Effect of Carnitine and Ergothioneine on Human Platelet Metabolism 1 , 1969, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[146]  D. Gründemann,et al.  Cyanobacteria produce high levels of ergothioneine , 2011 .

[147]  S. Golz,et al.  Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations. , 2007, Biochemical pharmacology.

[148]  T. Mann Studies on the metabolism of semen: 3. Fructose as a normal constituent of seminal plasma. Site of formation and function of fructose in semen. , 1946, The Biochemical journal.

[149]  O. Aruoma,et al.  The antioxidant action of ergothioneine. , 1991, Archives of biochemistry and biophysics.

[150]  P. Jocelyn The distribution of ergothioneine in blood as determined by a new method of estimation. , 1958, The Biochemical journal.

[151]  Sandra Coecke,et al.  Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine. , 2006, Clinical nutrition.

[152]  J. Nezu,et al.  Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1 , 1997, FEBS letters.

[153]  C. Cotman,et al.  In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. , 1991, Brain research.

[154]  R. Epand The role of dietary ergothioneine in the development of diabetes mellitus. , 1982, Medical hypotheses.

[155]  O. Aruoma,et al.  L-ergothioneine modulates oxidative damage in the kidney and liver of rats in vivo: studies upon the profile of polyunsaturated fatty acids. , 2004, Clinical nutrition.

[156]  B. Halliwell,et al.  Oxidation and generation of hydrogen peroxide by thiol compounds in commonly used cell culture media. , 2001, Biochemical and biophysical research communications.

[157]  G. Hunter The determination of ergothioneine in simple solution and in blood. , 1949, Canadian journal of research. Section E, Medical sciences.

[158]  T. Mann,et al.  Ergothioneine in the Seminal Vesicle Secretion , 1951, Nature.

[159]  J. Manson,et al.  Plasma Concentration of Interleukin-6 and C-reactive Protein and the Risk of Developing Type 2 Diabetes Mellitus Among Healthy Middle-Aged Women , 2001, Circulation.

[160]  B. Halliwell,et al.  Thiols and disulphides can aggravate peroxynitrite‐dependent inactivation of α1‐antiproteinase , 1997, FEBS letters.

[161]  A. Barton,et al.  Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patients. , 2005, Arthritis and rheumatism.

[162]  J. A. Behre,et al.  A NEW SULFUR-CONTAINING COMPOUND (THIASINE) IN THE BLOOD , 1926 .

[163]  B. Halliwell What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo? , 1997, FEBS letters.