All-inorganic perovskite quantum dot/TiO2 inverse opal electrode platform: stable and efficient photoelectrochemical sensing of dopamine under visible irradiation.

CsPbX3 (X = Cl, Br or I) perovskite quantum dots (PQDs) have attracted tremendous attention due to their extraordinarily excellent optical properties. However, there is still an obstacle for their bio-application, which is limited by their water-instability. In this work, we have designed a novel visible light triggered photoelectrochemical (PEC) sensor for dopamine (DA) based on CsPbBr1.5I1.5 PQD immobilized three-dimensional (3D) TiO2 inverse opal photonic crystals (IOPCs). Supported by the TiO2 IOPCs, the water-stability of the PQDs as well as that of the PEC sensor was considerably improved. Furthermore, employed as a photoactive material in PEC sensor, CsPbBr1.5I1.5 PQDs can expand the photocurrent response of the PEC sensor to the whole visible region. In addition, the modulation of the photonic stop band effect of TiO2 IOPCs on the incident light and the emission of PQDs could further enhance the photocurrent response. Such a PEC sensor demonstrates sensitive detection of DA in phosphate buffer saline solution and serum, with a good linear range from 0.1 μM to 250 μM and a low detection limit of approximately 0.012 μM. Our strategy opens an alternative horizon for PQD based PEC sensing, which could be more sensitive, convenient and inexpensive for clinical and biological analysis.

[1]  Ming Xu,et al.  Photoelectrochemical detection of glutathione by IrO2-hemin-TiO2 nanowire arrays. , 2013, Nano letters.

[2]  Zeger Hens,et al.  Highly Dynamic Ligand Binding and Light Absorption Coefficient of Cesium Lead Bromide Perovskite Nanocrystals. , 2016, ACS nano.

[3]  William W. Yu,et al.  Efficient and Stable White LEDs with Silica‐Coated Inorganic Perovskite Quantum Dots , 2016, Advanced materials.

[4]  H. Zeng,et al.  Quantum Dot Light‐Emitting Diodes Based on Inorganic Perovskite Cesium Lead Halides (CsPbX3) , 2015, Advanced materials.

[5]  Li Niu,et al.  Electrochemical sensor for dopamine based on a novel graphene-molecular imprinted polymers composite recognition element. , 2011, Biosensors & bioelectronics.

[6]  Yongsheng Zhu,et al.  Efficient energy transfer from inserted CdTe quantum dots to YVO₄:Eu³⁺ inverse opals: a novel strategy to improve and expand visible excitation of rare earth ions. , 2014, Nanoscale.

[7]  Cesare Soci,et al.  Lead iodide perovskite light-emitting field-effect transistor , 2015, Nature Communications.

[8]  Syed Mazhar Shah,et al.  Determination of catecholamine in human serum by a fluorescent quenching method based on a water-soluble fluorescent conjugated polymer-enzyme hybrid system. , 2012, The Analyst.

[9]  Sisi Liang,et al.  Enhancing the Stability of Perovskite Quantum Dots by Encapsulation in Crosslinked Polystyrene Beads via a Swelling–Shrinking Strategy toward Superior Water Resistance , 2017 .

[10]  Felix Deschler,et al.  Bright light-emitting diodes based on organometal halide perovskite. , 2014, Nature nanotechnology.

[11]  Oleksandr Isaienko,et al.  Spectral and Dynamical Properties of Single Excitons, Biexcitons, and Trions in Cesium-Lead-Halide Perovskite Quantum Dots. , 2016, Nano letters.

[12]  Guang-Li Wang,et al.  Dopamine sensitized nanoporous TiO2 film on electrodes: photoelectrochemical sensing of NADH under visible irradiation. , 2009, Biosensors & bioelectronics.

[13]  Itamar Willner,et al.  Photoelectrochemistry with ordered CdS nanoparticle/relay or photosensitizer/relay dyads on DNA scaffolds. , 2008, Angewandte Chemie.

[14]  Shin-Tson Wu,et al.  Ultrastable, Highly Luminescent Organic–Inorganic Perovskite–Polymer Composite Films , 2016, Advanced materials.

[15]  H. Pang,et al.  Electrochemical detection of dopamine using water-soluble sulfonated graphene , 2013 .

[16]  Yichuan Ling,et al.  Hydrogen-treated TiO2 nanowire arrays for photoelectrochemical water splitting. , 2011, Nano letters.

[17]  O. Mabrouk,et al.  In vivo neurochemical monitoring using benzoyl chloride derivatization and liquid chromatography-mass spectrometry. , 2012, Analytical chemistry.

[18]  Fan Yang,et al.  All-inorganic perovskite quantum dot/mesoporous TiO2 composite-based photodetectors with enhanced performance. , 2017, Dalton transactions.

[19]  H. Zeng,et al.  Stabilizing Cesium Lead Halide Perovskite Lattice through Mn(II) Substitution for Air-Stable Light-Emitting Diodes. , 2017, Journal of the American Chemical Society.

[20]  K. Davis,et al.  Dopamine in schizophrenia: a review and reconceptualization. , 1991, The American journal of psychiatry.

[21]  Wei-Wei Zhao,et al.  Photoelectrochemical DNA biosensors. , 2014, Chemical reviews.

[22]  Hongwei Song,et al.  NaYF4:Yb,Tm nanocrystals and TiO2 inverse opal composite films: a novel device for upconversion enhancement and solid-based sensing of avidin. , 2014, Nanoscale.

[23]  Hongwei Song,et al.  A sensitive photoelectrochemical biosensor for AFP detection based on ZnO inverse opal electrodes with signal amplification of CdS-QDs. , 2015, Biosensors & bioelectronics.

[24]  Christopher H. Hendon,et al.  Nanocrystals of Cesium Lead Halide Perovskites (CsPbX3, X = Cl, Br, and I): Novel Optoelectronic Materials Showing Bright Emission with Wide Color Gamut , 2015, Nano letters.

[25]  Willem L. Vos,et al.  Controlling the dynamics of spontaneous emission from quantum dots by photonic crystals , 2004, Nature.

[26]  Zhixiong Cai,et al.  Solar-induced photoelectrochemical sensing for dopamine based on TiO2 nanoparticles on g-C3N4 decorated graphene nanosheets , 2015 .

[27]  Chun-Yuan Huang,et al.  Hybridization of CsPbBr1.5I1.5 perovskite quantum dots with 9,9-dihexylfluorene co-oligomer for white electroluminescence , 2017 .

[28]  Q. Wei,et al.  Ultrasensitive photoelectrochemical aptasensing of miR-155 using efficient and stable CH3NH3PbI3 quantum dots sensitized ZnO nanosheets as light harvester. , 2016, Biosensors & bioelectronics.

[29]  Ursula Rothlisberger,et al.  Entropic stabilization of mixed A-cation ABX3 metal halide perovskites for high performance perovskite solar cells , 2016 .

[30]  B. Cheng,et al.  Insight into the effect of ligand-exchange on colloidal CsPbBr3 perovskite quantum dot/mesoporous-TiO2 composite-based photodetectors: much faster electron injection , 2017 .

[31]  Ru‐Shi Liu,et al.  Mesoporous Silica Particles Integrated with All-Inorganic CsPbBr3 Perovskite Quantum-Dot Nanocomposites (MP-PQDs) with High Stability and Wide Color Gamut Used for Backlight Display. , 2016, Angewandte Chemie.

[32]  Aijun Du,et al.  Ti3C2 MXene co-catalyst on metal sulfide photo-absorbers for enhanced visible-light photocatalytic hydrogen production , 2017, Nature Communications.

[33]  Aysegul Kutluay,et al.  An electrochemical sensor prepared by sonochemical one-pot synthesis of multi-walled carbon nanotube-supported cobalt nanoparticles for the simultaneous determination of paracetamol and dopamine. , 2014, Analytica chimica acta.

[34]  Edward H. Sargent,et al.  Perovskite photonic sources , 2016, Nature Photonics.

[35]  M. Fiebig,et al.  Low-threshold amplified spontaneous emission and lasing from colloidal nanocrystals of caesium lead halide perovskites , 2015, Nature Communications.

[36]  H. Ju,et al.  Charge recombination suppression-based photoelectrochemical strategy for detection of dopamine , 2012 .

[37]  W. Maragos,et al.  Neuronal cell death in Huntington’s disease: a potential role for dopamine , 2000, Trends in Neurosciences.

[38]  H. Zeng,et al.  All‐Inorganic Colloidal Perovskite Quantum Dots: A New Class of Lasing Materials with Favorable Characteristics , 2015, Advanced materials.

[39]  K. Uchida,et al.  Metal-catalyzed oxidation of protein-bound dopamine. , 2006, Biochemistry.

[40]  Wei Sun,et al.  Graphene nano sheet-fabricated electrochemical sensor for the determination of dopamine in the presence of ascorbic acid using cetyltrimethylammonium bromide as the discriminating agent , 2012 .

[41]  J. Bao,et al.  Cesium Lead Halide Perovskite Quantum Dots as a Photoluminescence Probe for Metal Ions , 2017, Advanced materials.

[42]  H. Zeng,et al.  Nonlinear Absorption and Low-Threshold Multiphoton Pumped Stimulated Emission from All-Inorganic Perovskite Nanocrystals. , 2016, Nano letters.

[43]  K. Domen,et al.  Recent advances in semiconductors for photocatalytic and photoelectrochemical water splitting. , 2014, Chemical Society reviews.

[44]  Dayang Wang,et al.  Interfacial Basicity-Guided Formation of Polydopamine Hollow Capsules in Pristine O/W Emulsions - Toward Understanding of Emulsion Template Roles , 2011 .

[45]  Jinhua Ye,et al.  Forced Impregnation Approach to Fabrication of Large-Area, Three-Dimensionally Ordered Macroporous Metal Oxides , 2010 .

[46]  Wei-Wei Zhao,et al.  Photoelectrochemical bioanalysis: the state of the art. , 2015, Chemical Society reviews.

[47]  R. McKay,et al.  Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease , 2002, Nature.

[48]  Hongyuan Chen,et al.  Ratiometric fluorescence, electrochemiluminescence, and photoelectrochemical chemo/biosensing based on semiconductor quantum dots. , 2016, Nanoscale.

[49]  D. Pang,et al.  Near-infrared electrogenerated chemiluminescence of ultrasmall Ag2Se quantum dots for the detection of dopamine. , 2012, Analytical chemistry.

[50]  Da Chen,et al.  Tuning Photoelectrochemical Performances of Ag−TiO2 Nanocomposites via Reduction/Oxidation of Ag , 2008 .

[51]  Haiyang Li,et al.  Embedding Perovskite Nanocrystals into a Polymer Matrix for Tunable Luminescence Probes in Cell Imaging , 2017 .

[52]  Wei-Wei Zhao,et al.  Photoelectrochemical enzymatic biosensors. , 2017, Biosensors & bioelectronics.

[53]  X. Xia,et al.  Electrochemical sensor based on nitrogen doped graphene: simultaneous determination of ascorbic acid, dopamine and uric acid. , 2012, Biosensors & bioelectronics.

[54]  Tsutomu Miyasaka,et al.  Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. , 2009, Journal of the American Chemical Society.