Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season

There are seasonal variations and gender differences in incidence of type 1 diabetes (T1D), metabolic control and responses to immune interventions at onset of the disease.

[1]  J. Rodríguez-Marín,et al.  Eating Habits, Physical Activity, Consumption of Substances and Eating Disorders in Adolescents , 2011, The Spanish journal of psychology.

[2]  G. Nordin,et al.  External quality assessment of HbA1c and its effect on comparison between Swedish pediatric diabetes clinics. Experiences from the Swedish pediatric diabetes quality register (Swediabkids) and Equalis , 2013, Clinical chemistry and laboratory medicine.

[3]  M. Fantone,et al.  Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus , 1997, Diabetes Care.

[4]  J. Ludvigsson,et al.  Seasonal Variation and Sex Differences of Circulating Macrophages, Immunoglobulins and Lymphocytes in Healthy School Children , 1993, Scandinavian journal of immunology.

[5]  C. Grimaldi,et al.  Hormonal regulation of B-cell function and systemic lupus erythematosus , 2008, Lupus.

[6]  J. Ludvigsson,et al.  Seasonality of Type 1 (insulin-dependent) diabetes mellitus: values of C-peptide, insulin antibodies and haemoglobin A1c show evidence of a more rapid loss of insulin secretion in epidemic patients , 1989, Diabetologia.

[7]  J. Ludvigsson,et al.  A1C in Children and Adolescents With Diabetes in Relation to Certain Clinical Parameters , 2008, Diabetes Care.

[8]  D. R. Gamble,et al.  The epidemiology of insulin dependent diabetes with particular reference to the relationship of virus infection to its etiology. , 1980, Epidemiologic reviews.

[9]  P. Raskin,et al.  Report of the expert committee on the diagnosis and classification of diabetes mellitus. , 1999, Diabetes care.

[10]  R. Dinesh,et al.  PD-1, gender, and autoimmunity. , 2010, Autoimmunity reviews.

[11]  C. Agardh,et al.  Gender differences in GAD antibody – positive diabetes mellitus in relation to age at onset, C‐peptide and other endocrine autoimmune diseases , 2004, Diabetes/metabolism research and reviews.

[12]  E. Moltchanova,et al.  Seasonal variation of diagnosis of Type 1 diabetes mellitus in children worldwide , 2009, Diabetic medicine : a journal of the British Diabetic Association.

[13]  J. Patrie,et al.  Pubertal alterations in growth and body composition. V. Energy expenditure, adiposity, and fat distribution. , 2000, American journal of physiology. Endocrinology and metabolism.

[14]  Juan Pedro López,et al.  GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus. , 2012, The New England journal of medicine.

[15]  T. Kawano,et al.  T Cell Subsets Related with a Sex Difference in IL-5 Production , 2011, International Archives of Allergy and Immunology.

[16]  J. Ludvigsson,et al.  C-Peptide in children with juvenile diabetes , 1976, Diabetologia.

[17]  L. Nyström,et al.  The incidence of Type I diabetes has not increased but shifted to a younger age at diagnosis in the 0–34 years group in Sweden 1983 to 1998 , 2002, Diabetologia.

[18]  Johnny Ludvigsson,et al.  GAD treatment and insulin secretion in recent-onset type 1 diabetes. , 2008, The New England journal of medicine.

[19]  J. Ludvigsson,et al.  Raised IgG and IgM in "epidemic" IDDM suggest that infections are responsible for the seasonality of type I diabetes. , 1991, Diabetes research.

[20]  R G McMurray,et al.  Changes in common activities of 3rd through 10th graders: the CHIC study. , 2000, Medicine and science in sports and exercise.

[21]  Å. Lernmark,et al.  C‐peptide in the classification of diabetes in children and adolescents , 2012, Pediatric diabetes.