Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
暂无分享,去创建一个
Hunna J. Watson | I. Ntalla | E. Zeggini | D. Pinto | S. Scherer | D. Rujescu | S. Cichon | I. Giegling | O. Andreassen | R. Ophoff | T. Werge | P. Sullivan | H. Hakonarson | C. Marshall | X. Estivill | N. Schork | G. Breen | A. Farmer | P. McGuffin | Yiran Guo | G. Stuber | P. Magistretti | N. Martin | P. Courtet | M. Kas | A. Palotie | S. Ripatti | A. Metspalu | T. Esko | I. Tachmazidou | K. Hatzikotoulas | G. Montgomery | K. Fischer | P. Lichtenstein | G. Escaramís | C. Dina | L. Petersen | R. Adan | R. Cone | P. Gorwood | S. Ehrlich | E. Walton | M. Maj | J. Lissowska | N. Pedersen | P. Slagboom | H. Inoko | J. Crowley | H. Gaspar | B. Herpertz-Dahlmann | J. Hauser | A. Bergen | S. Sorbi | P. Mortensen | M. Mattheisen | B. Nacmias | S. Gallinger | S. Medland | L. Karhunen | J. Kaprio | J. Kennedy | N. Ramoz | L. Duncan | J. Bryois | S. Ripke | L. Forétova | J. Hebebrand | A. Hinney | M. de Zwaan | S. Le Hellard | O. Davis | G. Dedoussis | E. Widén | L. Alfredsson | J. Grove | S. Hellard | C. Bulik | J. Szatkiewicz | L. Padyukov | L. Klareskog | M. Mattingsdal | U. Danner | J. Luykx | F. Fernández-Aranda | S. Jiménez-Murcia | U. Schmidt | C. Franklin | D. Whiteman | A. Henders | A. Scherag | S. Gordon | D. Dikeos | S. Zipfel | W. Herzog | J. Boden | L. Horwood | M. Landén | V. Janout | M. Navrátilová | L. Thornton | S. Zerwas | P. Slagboom | A. V. van Elburg | L. Huckins | Christopher Hübel | J. Pearson | J. Pantel | M. Forzan | M. Clementi | A. Forstner | M. Kennedy | J. Seitz | S. Herms | S. Guillaume | S. Crow | D. Dick | W. Kaye | W. Berrettini | P. Monteleone | J. Coleman | A. Julià | S. Marsal | K. Egberts | A. Tsitsika | A. Rotondo | A. Schosser | V. Leppä | G. Knudsen | P. Giusti-Rodríguez | James E Mitchell | T. Reichborn‐Kjennerud | F. Tozzi | E. Docampo | Y. Kim | V. Ricca | K. Kirk | J. Hudson | M. Fichter | R. Levitan | R. Rabionet | K. Klump | M. Strober | J. Baker | A. Juréus | A. Kaplan | D. Woodside | P. Santonastaso | J. Jordan | M. Dmitrzak-Węglarz | K. Mitchell | E. V. van Furth | A. Raevuori | A. Keski-Rahkonen | J. DeSocio | K. Halmi | I. Meulenbelt | J. Treasure | C. Boni | G. Kalsi | I. Boehm | F. Ritschel | K. Hanscombe | K. Purves | A. Monteleone | F. Rybakowski | A. Karwautz | Katrin Mannik | J. O'toole | S. Helder | A. Tortorella | F. Gonidakis | K. Tziouvas | Z. Yilmaz | G. Wagner | B. Świątkowska | C. Olsen | T. Wade | N. Micali | K. Kiezebrink | A. Favaro | T. Ando | R. Burghardt | H. Imgart | D. Degortes | E. Tenconi | A. Słopień | L. Šlachtová | M. Roberts | Dong Li | S. Yao | C. Norring | Anorexia Nervosa Genetics Initiative | M. Föcker | A. Birgegård | J. Larsen | L. Lilenfeld | M. S. '. Slof-Op 't Landt | H. Brandt | M. Cassina | S. Crawford | D. Kaminská | M. L. La Via | S. McDevitt | Melissa A. Munn-Chernoff | Richard Parker | V. B. Perica | Katharina Buehren | J. Giuranna | Monica Gratacos Mayora | M. Tyszkiewicz-Nwafor | Bochao D Lin | Craig Johnson | C. Hübel | E. F. Furth | H. Papežová | L. Foretova | M. Navratilova | Bochao D. Lin | T. Reichborn-Kjennerud | Marion E. Roberts | Paola Giusti-Rodríguez | N. Martin | S. Gordon | M. Zwaan | Héléna A. Gaspar | Shuyang Yao | Maria C. Via | Annemarie A. Elburg | Eating Disorder Working Group of the Psychiatric Genomics Consortium | N. Martin | N. Martin | N. Martin | M. S. ’. Slof-Op 't Landt | Annemarie Elburg | J. Kennedy | A. Elburg | Steven F. Crawford | Ilka Boehm | Franziska Ritschel | Anu Raevuori | M. C. Via
[1] O. Andreassen,et al. Psychiatric genetics and the structure of psychopathology , 2019, Molecular Psychiatry.
[2] P. O’Reilly,et al. Genomics of body fat percentage may contribute to sex bias in anorexia nervosa , 2018, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[3] Hunna J. Watson,et al. The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods. , 2018, Contemporary clinical trials.
[4] P. Donnelly,et al. The UK Biobank resource with deep phenotyping and genomic data , 2018, Nature.
[5] Patrick F. Sullivan,et al. Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits , 2018 .
[6] Tyrone D. Cannon,et al. Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence , 2018, Nature Genetics.
[7] Ann John,et al. Mental health in UK Biobank: development, implementation and results from an online questionnaire completed by 157 366 participants , 2018, BJPsych Open.
[8] Yan Li,et al. Easy Hi-C: A simple efficient protocol for 3D genome mapping in small cell populations , 2018, bioRxiv.
[9] P. Lichtenstein,et al. Assessing the evidence for shared genetic risks across psychiatric disorders and traits , 2017, Psychological Medicine.
[10] S. Ehrlich,et al. The Science Behind the Academy for Eating Disorders' Nine Truths About Eating Disorders , 2017, European eating disorders review : the journal of the Eating Disorders Association.
[11] G. Breen,et al. The Common Genetic Architecture of Anxiety Disorders , 2017, bioRxiv.
[12] Nicola J. Rinaldi,et al. Genetic effects on gene expression across human tissues , 2017, Nature.
[13] Mary Goldman,et al. Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics , 2016, Nature Communications.
[14] Jakob Grove,et al. Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder , 2017, bioRxiv.
[15] Robert M. Maier,et al. Causal associations between risk factors and common diseases inferred from GWAS summary data , 2017, Nature Communications.
[16] M. Daly,et al. The iPSYCH2012 case–cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders , 2017, Molecular Psychiatry.
[17] Gerome Breen,et al. Genetic identification of brain cell types underlying schizophrenia , 2017, Nature Genetics.
[18] J. Poulet,et al. Regulation of body weight and energy homeostasis by neuronal Cell adhesion molecule 1 , 2017, Nature Neuroscience.
[19] Raymond Walters,et al. Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa. , 2017, The American journal of psychiatry.
[20] N. Martin,et al. The Anorexia Nervosa Genetics Initiative: Study description and sample characteristics of the Australian and New Zealand arm , 2017, The Australian and New Zealand journal of psychiatry.
[21] S. Tonegawa,et al. Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors , 2017, Neuron.
[22] Nils Y. Hammerla,et al. Large Scale Population Assessment of Physical Activity Using Wrist Worn Accelerometers: The UK Biobank Study , 2017, PloS one.
[23] Evan Z. Macosko,et al. Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types , 2017, Nature Genetics.
[24] Kamryn T. Eddy,et al. Lifetime and 12-month prevalence of eating disorders amongst women in mid-life: a population-based study of diagnoses and risk factors , 2017, BMC Medicine.
[25] Job Dekker,et al. Mapping the 3D genome: Aiming for consilience , 2016, Nature Reviews Molecular Cell Biology.
[26] S. Dulawa,et al. Activity-Based Anorexia Alters the Expression of BDNF Transcripts in the Mesocorticolimbic Reward Circuit , 2016, PloS one.
[27] A. Keski-Rahkonen,et al. Epidemiology of eating disorders in Europe: prevalence, incidence, comorbidity, course, consequences, and risk factors , 2016, Current opinion in psychiatry.
[28] Daning Lu,et al. Chromosome conformation elucidates regulatory relationships in developing human brain , 2016, Nature.
[29] K. Campbell,et al. Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells , 2016, The Journal of Neuroscience.
[30] John C Marioni,et al. A step-by-step workflow for low-level analysis of single-cell RNA-seq data with Bioconductor , 2016, F1000Research.
[31] Krishna R. Kalari,et al. Beta-Poisson model for single-cell RNA-seq data analyses , 2016, Bioinform..
[32] May E. Montasser,et al. Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci , 2016, Diabetes.
[33] Benjamin A. Logsdon,et al. Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia , 2016, Nature Neuroscience.
[34] Tom R. Gaunt,et al. LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis , 2016, bioRxiv.
[35] Jonathan P. Beauchamp,et al. Genome-wide association study identifies 74 loci associated with educational attainment , 2016, Nature.
[36] Janice M. Fullerton,et al. Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder , 2016, bioRxiv.
[37] C. Lüscher,et al. Accumbal D1R Neurons Projecting to Lateral Hypothalamus Authorize Feeding , 2015, Neuron.
[38] P. Lichtenstein,et al. Etiological overlap between obsessive‐compulsive disorder and anorexia nervosa: a longitudinal cohort, multigenerational family and twin study , 2015, World psychiatry : official journal of the World Psychiatric Association.
[39] Yakir A Reshef,et al. Partitioning heritability by functional annotation using genome-wide association summary statistics , 2015, Nature Genetics.
[40] Joseph K. Pickrell,et al. Detection and interpretation of shared genetic influences on 42 human traits , 2015, Nature Genetics.
[41] V. Bello,et al. The dystroglycan: nestled in an adhesome during embryonic development. , 2015, Developmental biology.
[42] M. Daly,et al. An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.
[43] Joris M. Mooij,et al. MAGMA: Generalized Gene-Set Analysis of GWAS Data , 2015, PLoS Comput. Biol..
[44] C. Bulik,et al. Genetics and Epigenetics of Eating Disorders. , 2015, Advances in genomics and genetics.
[45] P. Elliott,et al. UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age , 2015, PLoS medicine.
[46] Ross M. Fraser,et al. Genetic studies of body mass index yield new insights for obesity biology , 2015, Nature.
[47] Jack Euesden,et al. PRSice: Polygenic Risk Score software , 2014, Bioinform..
[48] Aaron J. Sams,et al. Accounting for eXentricities: Analysis of the X Chromosome in GWAS Reveals X-Linked Genes Implicated in Autoimmune Diseases , 2014, bioRxiv.
[49] Carson C Chow,et al. Second-generation PLINK: rising to the challenge of larger and richer datasets , 2014, GigaScience.
[50] Naomi R. Wray,et al. Genetic Studies of Major Depressive Disorder: Why Are There No Genome-wide Association Study Findings and What Can We Do About It? , 2014, Biological Psychiatry.
[51] H. Monyer,et al. Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behaviour , 2014, Molecular Psychiatry.
[52] A. Munnich,et al. Identification of a novel ARL13B variant in a Joubert syndrome-affected patient with retinal impairment and obesity , 2014, European Journal of Human Genetics.
[53] B. Berger,et al. Efficient Bayesian mixed model analysis increases association power in large cohorts , 2014, Nature Genetics.
[54] C. Spencer,et al. Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.
[55] N. Cox,et al. Obesity-associated variants within FTO form long-range functional connections with IRX3 , 2014, Nature.
[56] Janice M. Fullerton,et al. Genome-wide association study reveals two new risk loci for bipolar disorder , 2014, Nature Communications.
[57] M. Daly,et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.
[58] Jonathan J. Evans,et al. Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants , 2013, PloS one.
[59] Simon C. Potter,et al. Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia , 2013, Nature Genetics.
[60] D. Koller,et al. Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals , 2013, Genome research.
[61] Reiko Nishihara,et al. Prospective analysis of body mass index, physical activity, and colorectal cancer risk associated with β-catenin (CTNNB1) status. , 2013, Cancer research.
[62] Hunna J. Watson,et al. Update on the treatment of anorexia nervosa: review of clinical trials, practice guidelines and emerging interventions , 2012, Psychological Medicine.
[63] E. Anton,et al. Arl13b in primary cilia regulates the migration and placement of interneurons in the developing cerebral cortex. , 2012, Developmental cell.
[64] Kenny Q. Ye,et al. An integrated map of genetic variation from 1,092 human genomes , 2012, Nature.
[65] Susan C. Brown,et al. The dystrophin–glycoprotein complex in brain development and disease , 2012, Trends in Neurosciences.
[66] D. Whiteman,et al. Cohort profile: the QSkin Sun and Health Study. , 2012, International journal of epidemiology.
[67] Tanya M. Teslovich,et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes , 2012, Nature Genetics.
[68] J. Dostie,et al. Discovering genome regulation with 3C and 3C-related technologies. , 2012, Biochimica et biophysica acta.
[69] Michael T. McManus,et al. An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production , 2012, PLoS genetics.
[70] Albert J. Vilella,et al. A high-resolution map of human evolutionary constraint using 29 mammals , 2011, Nature.
[71] I. Ntalla,et al. A genome-wide association study of anorexia nervosa , 2011, Molecular Psychiatry.
[72] A. Mitchell,et al. Mortality rates in patients with anorexia nervosa and other eating disorders. A meta-analysis of 36 studies. , 2011, Archives of general psychiatry.
[73] O. Mors,et al. The Danish Psychiatric Central Research Register , 2011, Scandinavian journal of public health.
[74] Mark I McCarthy,et al. Genomic inflation factors under polygenic inheritance , 2011, European Journal of Human Genetics.
[75] P. Magistretti,et al. Absence of association between specific common variants of the obesity‐related FTO gene and psychological and behavioral eating disorder phenotypes , 2011, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[76] S. Zhong,et al. A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium , 2011, PLoS genetics.
[77] P. Visscher,et al. GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.
[78] Patrick F. Sullivan,et al. LifeGene—a large prospective population-based study of global relevance , 2010, European Journal of Epidemiology.
[79] K. Campbell,et al. Distinct Functions of Glial and Neuronal Dystroglycan in the Developing and Adult Mouse Brain , 2010, The Journal of Neuroscience.
[80] K. Berridge,et al. The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders , 2010, Brain Research.
[81] Tanya M. Teslovich,et al. Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids , 2010, Nature.
[82] Yun Li,et al. METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..
[83] R. Deane,et al. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. , 2010, Blood.
[84] Michael D. Cole,et al. Upregulation of c-MYC in cis through a Large Chromatin Loop Linked to a Cancer Risk-Associated Single-Nucleotide Polymorphism in Colorectal Cancer Cells , 2010, Molecular and Cellular Biology.
[85] Christopher A. Haiman,et al. The 8q24 cancer risk variant rs6983267 demonstrates long-range interaction with MYC in colorectal cancer , 2009, Nature Genetics.
[86] Frederico A. C. Azevedo,et al. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled‐up primate brain , 2009, The Journal of comparative neurology.
[87] Joshua M. Korn,et al. Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs , 2008, Nature Genetics.
[88] Colin A. Johnson,et al. Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. , 2008, American journal of human genetics.
[89] R. Dalle Grave,et al. Compulsive exercise to control shape or weight in eating disorders: prevalence, associated features, and treatment outcome. , 2008, Comprehensive psychiatry.
[90] I. Borecki,et al. Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; The NHLBI Family Heart Study , 2008, BMC Medical Genetics.
[91] Job Dekker,et al. Gene Regulation in the Third Dimension , 2008, Science.
[92] N. Spruston. Pyramidal neurons: dendritic structure and synaptic integration , 2008, Nature Reviews Neuroscience.
[93] Y. Xing,et al. A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function , 2008, The Journal of Neuroscience.
[94] R. Kessler,et al. The Prevalence and Correlates of Eating Disorders in the National Comorbidity Survey Replication , 2007, Biological Psychiatry.
[95] Joshua S. Yuan,et al. A type IV P-type ATPase affects insulin-mediated glucose uptake in adipose tissue and skeletal muscle in mice. , 2006, The Journal of nutritional biochemistry.
[96] C. Bulik,et al. Relationships between features associated with vomiting in purging-type eating disorders. , 2005, The International journal of eating disorders.
[97] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[98] N. Craddock,et al. Design of Case‐controls Studies with Unscreened Controls , 2005, Annals of human genetics.
[99] C. Bulik,et al. Comorbidity of anxiety disorders with anorexia and bulimia nervosa. , 2004, The American journal of psychiatry.
[100] B. Devlin,et al. Genetic analysis of bulimia nervosa: methods and sample description. , 2004, The International journal of eating disorders.
[101] Anjen Chenn,et al. Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors , 2002, Science.
[102] J. Ioannidis,et al. Replication validity of genetic association studies , 2001, Nature Genetics.
[103] T. Saito,et al. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. , 2000, Biochemical and biophysical research communications.
[104] David Goldman,et al. A search for susceptibility loci for anorexia nervosa: methods and sample description , 2000, Biological Psychiatry.
[105] J. Morgan. Genetic epidemiology of binging and vomiting , 1998, British Journal of Psychiatry.
[106] R. Kessler,et al. The World Health Organization Composite International Diagnostic Interview short‐form (CIDI‐SF) , 1998 .
[107] Y. Benjamini,et al. Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .
[108] H. Eysenck,et al. A revised version of the Psychoticism scale. , 1985 .