The medical effects of mold exposure.

Exposure to molds can cause human disease through several well-defined mechanisms. In addition, many new mold-related illnesses have been hypothesized in recent years that remain largely or completely unproved. Concerns about mold exposure and its effects are so common that all health care providers, particularly allergists and immunologists, are frequently faced with issues regarding these real and asserted mold-related illnesses. The purpose of this position paper is to provide a state-of-the-art review of the role that molds are known to play in human disease, including asthma, allergic rhinitis, allergic bronchopulmonary aspergillosis, sinusitis, and hypersensitivity pneumonitis. In addition, other purported mold-related illnesses and the data that currently exist to support them are carefully reviewed, as are the currently available approaches for the evaluation of both patients and the environment.

[1]  Katz,et al.  Indoor survey of moulds and prevalence of mould atopy in Israel , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[2]  Kari Reijula,et al.  IgE-mediated allergy to fungal allergens in Finland with special reference to Alternaria alternata and Cladosporium herbarum. , 2003, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[3]  T. Holford,et al.  Symptoms of wheeze and persistent cough in the first year of life: associations with indoor allergens, air contaminants, and maternal history of asthma. , 2003, American journal of epidemiology.

[4]  Daniel M Lewis,et al.  Clinical use of immunoassays in assessing exposure to fungi and potential health effects related to fungal exposure. , 2004, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[5]  R. Feigin,et al.  Textbook of Pediatric Infectious Diseases , 1986 .

[6]  J. Peat,et al.  Effects of damp and mould in the home on respiratory health: a review of the literature , 1998, Allergy.

[7]  B. D. Coate,et al.  Daily asthma severity in relation to personal ozone exposure and outdoor fungal spores. , 1996, American journal of respiratory and critical care medicine.

[8]  G. Marks,et al.  Natural exposure to Alternaria spores induces allergic rhinitis symptoms in sensitized children , 2003, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[9]  A. Verhoeff,et al.  Health risk assessment of fungi in home environments. , 1997, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[10]  Pertti Pasanen,et al.  Critical aspects on the significance of microbial volatile metabolites as indoor air pollutants , 1998 .

[11]  T. Holford,et al.  Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma. , 2002, Environmental health perspectives.

[12]  John E. Bennett,et al.  Principles and practice of infectious diseases. Vols 1 and 2. , 1979 .

[13]  J. Kimbrough,et al.  Mold Allergyisa is a sk Factor for Persistent Cold-Like Symptoms in Children , 1997, Clinical pediatrics.

[14]  A. Vojdani,et al.  Mixed Mold Mycotoxicosis: Immunological Changes in Humans following Exposure in Water-Damaged Buildings , 2003, Archives of environmental health.

[15]  P. Turkeltaub,et al.  The association of individual allergen reactivity with respiratory disease in a national sample: data from the second National Health and Nutrition Examination Survey, 1976-80 (NHANES II). , 1992, The Journal of allergy and clinical immunology.

[16]  D. Ownby,et al.  Evaluation of the cause of nasal and ocular symptoms associated with lawn mowing. , 1986, The Journal of allergy and clinical immunology.

[17]  R. Bush,et al.  Alternaria-induced asthma. , 2004, The Journal of allergy and clinical immunology.

[18]  D. Zavala,et al.  Comparative prevalence of sensitization to common animal, plant and mould allergens in subjects with asthma, or atopic dermatitis and/or allergic rhinitis living in a tropical environment , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[19]  A. Vojdani,et al.  Mold and mycotoxins: effects on the neurological and immune systems in humans. , 2004, Advances in applied microbiology.

[20]  W. Pichler,et al.  Mushroom (Basidiomycete) allergy: diagnosis established by skin test and nasal challenge. , 1998, The Journal of allergy and clinical immunology.

[21]  Lonie J Swenson,et al.  Risk from Inhaled Mycotoxins in Indoor Office and Residential Environments , 2004, International journal of toxicology.

[22]  Disease Prevention,et al.  Damp Indoor Spaces and Health , 2004 .

[23]  J. Salvaggio Use and misuse of biomarker tests in "environmental conditions". , 1994, The Journal of allergy and clinical immunology.

[24]  D. Carpenter Clearing the Air: Asthma and Indoor Air Exposure , 2004 .

[25]  R. Clark,et al.  Health Effects of Mycotoxins: A Toxicological Overview , 2004, Journal of toxicology. Clinical toxicology.

[26]  T. Meklin,et al.  Immunoglobulin G antibodies to moulds in school-children from moisture problem schools , 2002 .

[27]  E. King,et al.  Air Sampling Instruments , 1969 .

[28]  P. Pasanen,et al.  Volatile organic metabolites associated with some toxic fungi and their mycotoxins , 1996 .

[29]  FUNGAL SPORES AS SUCH DO NOT CAUSE NASAL INFLAMMATION IN MOLD EXPOSURE , 2002, Inhalation toxicology.

[30]  Linda Monaci,et al.  Determination of ochratoxin A in foods: state-of-the-art and analytical challenges , 2004, Analytical and bioanalytical chemistry.

[31]  H. Meyer,et al.  Serum IgE specific to indoor moulds, measured by basophil histamine release, is associated with building-related symptoms in damp buildings , 2001, Inflammation Research.

[32]  T. Platts-Mills,et al.  Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and nonasthmatic control subjects. , 1999, The Journal of allergy and clinical immunology.

[33]  B. Marple,et al.  Allergic fungal rhinosinusitis , 2004, Current allergy and asthma reports.

[34]  Robert G Hamilton,et al.  In vitro assays for the diagnosis of IgE-mediated disorders. , 2004, The Journal of allergy and clinical immunology.