Comparison of deep learning convolutional neural network (CNN) architectures for CT lung cancer classification

Lung cancer has become one of the most common deaths amongst the cancer patients. World Health Organisation states that lung cancer is the second most fatal cancer all over the world in 2014. Alarmingly, most of the lung cancer patients are diagnosed at the later stages where the cancer has spreads. Thus, early screening via Computed Tomography scan particularly among active smokers is encouraged. Manual diagnosis of the cancer is made feasible through the integration of Computer Aided Diagnosis system. For the past few years, deep learning method leads most of the artificial based intelligence applications including CAD systems. This paper aims to investigate the performance of five newly established Convolutional Neural Network architectures; GoogleNet, SqueezeNet, DenseNet, ShuffleNet and MobileNetV2 to classify lung tumours into malignant and benign categories using LIDC-IDRI datasets. Their performances are measured in terms of accuracy, sensitivity, specificity and area under the curve of the receiver operating characteristic curve. Experimental results show that GoogleNet is the best CNN architecture for CT lung tumour classification wih an accuracy of 94.53%, specificity 99.06%, sensitivity of 65.67% and AUC 86.84%.

[1]  Kilian Q. Weinberger,et al.  Densely Connected Convolutional Networks , 2016, 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[2]  Ashrani Aizzuddin Abd. Rahni,et al.  Development of a semi-automated combined PET and CT lung lesion segmentation framework , 2017, Medical Imaging.

[3]  Richard C. Pais,et al.  The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): a completed reference database of lung nodules on CT scans. , 2011, Medical physics.

[4]  Denise R. Aberle,et al.  An Interpretable Deep Hierarchical Semantic Convolutional Neural Network for Lung Nodule Malignancy Classification , 2018, Expert Syst. Appl..

[5]  Haibo Hu,et al.  Automated Lung Nodule Detection and Classification Using Deep Learning Combined with Multiple Strategies , 2019, Sensors.

[6]  Dumitru Erhan,et al.  Going deeper with convolutions , 2014, 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[7]  Forrest N. Iandola,et al.  SqueezeNet: AlexNet-level accuracy with 50x fewer parameters and <1MB model size , 2016, ArXiv.

[8]  Qingzeng Song,et al.  Using Deep Learning for Classification of Lung Nodules on Computed Tomography Images , 2017, Journal of healthcare engineering.

[9]  June-Goo Lee,et al.  Deep Learning in Medical Imaging: General Overview , 2017, Korean journal of radiology.

[10]  Jean-Christophe Burie,et al.  Improving Accuracy of Lung Nodule Classification Using Deep Learning with Focal Loss , 2019, Journal of healthcare engineering.

[11]  Xiangyu Zhang,et al.  ShuffleNet: An Extremely Efficient Convolutional Neural Network for Mobile Devices , 2017, 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition.

[12]  Gilu K Abraham,et al.  Lung Nodule Classification in CT Images Using Convolutional Neural Network , 2019, 2019 9th International Conference on Advances in Computing and Communication (ICACC).

[13]  Hwee Kuan Lee,et al.  Gated-Dilated Networks for Lung Nodule Classification in CT Scans , 2019, IEEE Access.

[14]  K. Chan,et al.  A Review of Lung Cancer Research in Malaysia. , 2016, The Medical journal of Malaysia.

[15]  Lubomir M. Hadjiiski,et al.  Computer-aided diagnosis in the era of deep learning. , 2020, Medical physics.

[16]  Mark Sandler,et al.  MobileNetV2: Inverted Residuals and Linear Bottlenecks , 2018, 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition.