Inhibition of Nuclear Receptor Related Orphan Receptor γ Ameliorates Mechanical Hypersensitivity Through the Suppression of Spinal Microglial Activation

[1]  N. Morioka,et al.  Anti-interleukin-6 receptor antibody improves allodynia and cognitive impairment in mice with neuropathic pain following partial sciatic nerve ligation. , 2022, International immunopharmacology.

[2]  A. Yu,et al.  Nuclear receptor RORγ inverse agonists/antagonists display tissue- and gene-context selectivity through distinct activities in altering chromatin accessibility and master regulator SREBP2 occupancy. , 2022, Pharmacological research.

[3]  N. Morioka,et al.  Stimulation of nuclear receptor REV-ERBs suppresses inflammatory responses in spinal microglia , 2021, Neurochemistry International.

[4]  Xiong Zhang,et al.  RORγ is a context-specific master regulator of cholesterol biosynthesis and an emerging therapeutic target in cancer and autoimmune diseases. , 2021, Biochemical pharmacology.

[5]  M. Malcangio,et al.  Microglial heterogeneity in chronic pain , 2021, Brain, Behavior, and Immunity.

[6]  K. Ley,et al.  Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain , 2021, The Journal of experimental medicine.

[7]  M. Nishibori,et al.  Perineural high-mobility group box 1 induces mechanical hypersensitivity through activation of spinal microglia: involvement of glutamate-NMDA receptor dependent mechanism in spinal dorsal horn. , 2021, Biochemical pharmacology.

[8]  J. McDonald,et al.  GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain , 2020, The Journal of Pharmacology and Experimental Therapeutics.

[9]  Marina Grimaldi,et al.  Assessing the Selectivity of FXR, LXRs, CAR, and RORγ Pharmaceutical Ligands With Reporter Cell Lines , 2020, Frontiers in Pharmacology.

[10]  N. Morioka,et al.  TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia. , 2020, Journal of pharmacological sciences.

[11]  G. Petsko,et al.  25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner , 2020, Journal of Neuroinflammation.

[12]  A. Jetten,et al.  (Inverse) Agonists of Retinoic Acid-Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease. , 2020, Annual review of pharmacology and toxicology.

[13]  X. Gu,et al.  Imbalanced spinal infiltration of Th17/Treg cells contributes to bone cancer pain via promoting microglial activation , 2019, Brain, Behavior, and Immunity.

[14]  N. Morioka,et al.  Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice , 2019, Brain, Behavior, and Immunity.

[15]  K. Higashino,et al.  Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors , 2018, Pain.

[16]  Fen Li,et al.  Interleukin‐1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel‐associated acute pain syndrome , 2018, Glia.

[17]  Hojung Nam,et al.  The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis , 2019, Nature.

[18]  H. Hirai,et al.  Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology , 2019, Neurobiology of Disease.

[19]  F. Bihl,et al.  Sulfoximines as potent RORγ inverse agonists. , 2018, Bioorganic & medicinal chemistry letters.

[20]  M. Zhuo,et al.  Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex , 2017, Journal of neurochemistry.

[21]  Yu-Qiu Zhang,et al.  Pain regulation by non-neuronal cells and inflammation , 2016, Science.

[22]  G. Muccioli,et al.  Oxysterols: From cholesterol metabolites to key mediators. , 2016, Progress in lipid research.

[23]  A. Agrotis,et al.  Inhibition of the Nuclear Receptor ROR&ggr; and Interleukin-17A Suppresses Neovascular Retinopathy: Involvement of Immunocompetent Microglia , 2016, Arteriosclerosis, thrombosis, and vascular biology.

[24]  N. Morioka,et al.  Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice , 2016, Molecular and Cellular Neuroscience.

[25]  N. Morioka,et al.  Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells. , 2016, Biochemical and biophysical research communications.

[26]  N. Morioka,et al.  Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice , 2015, Brain, Behavior, and Immunity.

[27]  T. Ikemoto,et al.  Chronic Pain in the Japanese Community—Prevalence, Characteristics and Impact on Quality of Life , 2015, PloS one.

[28]  N. Morioka,et al.  Downregulation of connexin36 in mouse spinal dorsal horn neurons leads to mechanical allodynia , 2015, Journal of neuroscience research.

[29]  T. Kizaki,et al.  Direct and Indirect Suppression of Interleukin-6 Gene Expression in Murine Macrophages by Nuclear Orphan Receptor REV-ERBα , 2014, TheScientificWorldJournal.

[30]  N. Morioka,et al.  A β1/2 Adrenergic Receptor‐Sensitive Intracellular Signaling Pathway Modulates CCL2 Production in Cultured Spinal Astrocytes , 2014, Journal of cellular physiology.

[31]  S. Maier,et al.  Pathological pain and the neuroimmune interface , 2014, Nature Reviews Immunology.

[32]  Douglas J. Kojetin,et al.  REV-ERB and ROR nuclear receptors as drug targets , 2014, Nature Reviews Drug Discovery.

[33]  N. Morioka,et al.  The activation of P2Y6 receptor in cultured spinal microglia induces the production of CCL2 through the MAP kinases-NF-κB pathway , 2013, Neuropharmacology.

[34]  P. Griffin,et al.  Identification of SR2211: a potent synthetic RORγ-selective modulator. , 2012, ACS chemical biology.

[35]  J. Mariani,et al.  The nuclear receptor RORα exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes , 2009, Proceedings of the National Academy of Sciences.

[36]  A. Jetten.  Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism , 2009, Nuclear receptor signaling.

[37]  C. Gravel,et al.  BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain , 2005, Nature.

[38]  M. Becker‐André,et al.  A novel isoform of the orphan nuclear receptor RORbeta is specifically expressed in pineal gland and retina. , 1998, Gene.

[39]  B. Birren,et al.  Disruption of the nuclear hormone receptor RORα in staggerer mice , 1996, Nature.

[40]  J. Mallet,et al.  Retinoid-Related Orphan Receptor α Controls the Early Steps of Purkinje Cell Dendritic Differentiation , 2006, The Journal of Neuroscience.