A structurally distinct immunosuppressive TGF-mimic from an intestinal helminth that potently induces murine and human regulatory T cells
暂无分享,去创建一个
A. Hinck | A. Ivens | R. Maizels | R. Chambers | C. Hinck | D. Soares | S. Wigmore | H. McSorley | Y. Harcus | J. Hewitson | K. Filbey | D. Smyth | S. Anderton | T. Bihan | T. Brenn | Kara J. Filbey | C. Johnston | M. White | Ravindra B. Kodali | D. C. Soares | Anna O. Kildemoes | A. Kemter | Hannah V. Woodcock | A. Kildemoes
[1] T. Woollings. Trades , 2019, Jet Stream.
[2] M. Karimi,et al. Mesenchymal stem cells increase skin graft survival time and up-regulate PD-L1 expression in splenocytes of mice. , 2017, Immunology letters.
[3] A. Hinck,et al. Structural Biology and Evolution of the TGF-β Family. , 2016, Cold Spring Harbor perspectives in biology.
[4] Troy C. Krzysiak,et al. Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling , 2016, Biochemistry.
[5] Richard D Emes,et al. A Trematode Parasite Derived Growth Factor Binds and Exerts Influences on Host Immune Functions via Host Cytokine Receptor Complexes , 2016, PLoS pathogens.
[6] R. Maizels,et al. Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths , 2015, Mucosal Immunology.
[7] H. Fan,et al. IL-25 promotes the function of CD4+CD25+ T regulatory cells and prolongs skin-graft survival in murine models. , 2015, International immunopharmacology.
[8] R. Maizels,et al. Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products , 2015, Journal of visualized experiments : JoVE.
[9] W. Młynarski,et al. Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up. , 2014, Clinical immunology.
[10] Deepali V. Sawant,et al. Once a Treg, always a Treg? , 2014, Immunological reviews.
[11] Yat T. Tang,et al. Genome of the human hookworm Necator americanus , 2014, Nature Genetics.
[12] R. Maizels,et al. Helminths and Immunological Tolerance , 2014, Transplantation.
[13] D. Rifkin,et al. Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation. , 2013, Cytokine & growth factor reviews.
[14] R. Maizels,et al. Helminth Infections and Host Immune Regulation , 2012, Clinical Microbiology Reviews.
[15] Wenqing Cai,et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. , 2012, Cell Stem Cell.
[16] J. Lafaille,et al. Induced CD4+Foxp3+ regulatory T cells in immune tolerance. , 2012, Annual review of immunology.
[17] D. Tran. TGF-β: the sword, the wand, and the shield of FOXP3(+) regulatory T cells. , 2012, Journal of molecular cell biology.
[18] R. Maizels,et al. Regulatory T Cells in Infection , 2011, Advances in Immunology.
[19] T. Geary,et al. Proteomic Analysis of Excretory-Secretory Products of Heligmosomoides polygyrus Assessed with Next-Generation Sequencing Transcriptomic Information , 2011, PLoS neglected tropical diseases.
[20] M. Blaxter,et al. Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins. , 2011, Journal of proteomics.
[21] Charles P. Lin,et al. Immune recognition and rejection of allogeneic skin grafts. , 2011, Immunotherapy.
[22] A. Hinck,et al. TGF‐β signalling is mediated by two autonomously functioning TβRI:TβRII pairs , 2011, The EMBO journal.
[23] C. Loddenkemper,et al. Strongyloides ratti Infection Induces Expansion of Foxp3+ Regulatory T Cells That Interfere with Immune Response and Parasite Clearance in BALB/c Mice , 2011, The Journal of Immunology.
[24] A. Rudensky,et al. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway , 2010, The Journal of experimental medicine.
[25] A. Hinck,et al. Ternary Complex of Transforming Growth Factor-β1 Reveals Isoform-specific Ligand Recognition and Receptor Recruitment in the Superfamily* , 2010, The Journal of Biological Chemistry.
[26] R. Maizels,et al. daf-7-related TGF-β homologues from Trichostrongyloid nematodes show contrasting life-cycle expression patterns , 2009, Parasitology.
[27] R. Dana,et al. Levels of Foxp3 in Regulatory T Cells Reflect Their Functional Status in Transplantation1 , 2009, The Journal of Immunology.
[28] R. Flavell,et al. TGF-β: A Master of All T Cell Trades , 2008, Cell.
[29] Chen Dong,et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. , 2008, Immunity.
[30] A. Kulkarni,et al. A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells , 2008, Nature Immunology.
[31] Yuelei Shen,et al. TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function , 2008, Nature.
[32] C. Loddenkemper,et al. Functional Analysis of Effector and Regulatory T Cells in a Parasitic Nematode Infection , 2008, Infection and Immunity.
[33] A. Hinck,et al. Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. , 2008, Molecular cell.
[34] R. Maizels,et al. Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection , 2007, European journal of immunology.
[35] D. Elliott,et al. Helminths as governors of immune-mediated inflammation. , 2007, International journal for parasitology.
[36] S. Akira,et al. TLR Engagement Prevents Transplantation Tolerance , 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
[37] H. Weiner,et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells , 2006, Nature.
[38] P. Knaus,et al. A member of the transforming growth factor-beta receptor family from Echinococcus multilocularis is activated by human bone morphogenetic protein 2. , 2006, Molecular and biochemical parasitology.
[39] T. Wyss-Coray,et al. Highly sensitive and specific bioassay for measuring bioactive TGF-β , 2006, BMC Cell Biology.
[40] A. Hinck,et al. Assembly of TβRI: TβRII:TGFβ ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependent , 2005 .
[41] R. Maizels,et al. Suppression of allergic airway inflammation by helminth-induced regulatory T cells , 2005, The Journal of experimental medicine.
[42] R. Maizels,et al. Removal of Regulatory T Cell Activity Reverses Hyporesponsiveness and Leads to Filarial Parasite Clearance In Vivo1 , 2005, The Journal of Immunology.
[43] A. Rudensky,et al. TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells , 2005, The Journal of experimental medicine.
[44] A. Rudensky,et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. , 2005, Immunity.
[45] R. Flavell,et al. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[46] Li Li,et al. Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 , 2003, The Journal of experimental medicine.
[47] A. Hinck,et al. Solution structure and backbone dynamics of the TGFbeta type II receptor extracellular domain. , 2003, Biochemistry.
[48] A. Reith,et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. , 2002, Molecular pharmacology.
[49] E. Pearce,et al. Human Transforming Growth Factor-β Activates a Receptor Serine/Threonine Kinase from the Intravascular ParasiteSchistosoma mansoni * , 2001, The Journal of Biological Chemistry.
[50] A. Mellor,et al. Differential Susceptibility of Heart, Skin, and Islet Allografts to T Cell-Mediated Rejection1 , 2001, The Journal of Immunology.
[51] C. Niehrs,et al. Silencing of TGF-β signalling by the pseudoreceptor BAMBI , 1999, Nature.
[52] J H Barker,et al. Scoring of skin rejection in a swine composite tissue allograft model. , 1999, The Journal of surgical research.
[53] M. Ferguson,et al. Transforming growth factor–β3 is required for secondary palate fusion , 1995, Nature Genetics.
[54] R. Kühn,et al. IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma. , 1994, Journal of immunology.
[55] D. Riddle,et al. The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development , 1993, Nature.
[56] J. Dasch,et al. Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification. , 1989, Journal of immunology.
[57] M. Sporn,et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[58] P. Medawar,et al. ACQUIRED TOLERANCE OF SKIN HOMOGRAFTS , 1955, Annals of the New York Academy of Sciences.
[59] A. Hinck,et al. Production, Isolation, and Structural Analysis of Ligands and Receptors of the TGF-β Superfamily. , 2016, Methods in molecular biology.
[60] Antonio Alcami,et al. Viral mimicry of cytokines, chemokines and their receptors , 2003, Nature Reviews Immunology.
[61] P. Schatz,et al. Biotinylation of proteins in vivo and in vitro using small peptide tags. , 2000, Methods in enzymology.
[62] R. W. Padgett,et al. TGFβ-related pathways: roles in Caenorhabditis elegans development , 2000 .
[63] G. Boivin,et al. TGF β 2 knockout mice have multiple developmental defects that are non-overlapping with other TGF β knockout phenotypes , 1997 .