A structurally distinct immunosuppressive TGF-mimic from an intestinal helminth that potently induces murine and human regulatory T cells

Citation for published version: Johnston, CJC, Smyth, D, Kodali, RB, White, MPJ, Harcus, Y, Filbey, K, Hewitson, J, Hinck, CS, Ivens, A, Kemter, A, Kildemoes, AO, Le Bihan, T, Soares, D, Anderton, S, Brenn, T, Wigmore, S, Woodcock, H, Chambers, RC, Hinck, AP, McSorley, H & Maizels, R 2017, 'A structurally distinct immunosuppressive TGFmimic from an intestinal helminth that potently induces murine and human regulatory T cells' Nature Communications, vol. 8, 1741. DOI: 10.1038/s41467-017-01886-6

[1]  T. Woollings Trades , 2019, Jet Stream.

[2]  M. Karimi,et al.  Mesenchymal stem cells increase skin graft survival time and up-regulate PD-L1 expression in splenocytes of mice. , 2017, Immunology letters.

[3]  A. Hinck,et al.  Structural Biology and Evolution of the TGF-β Family. , 2016, Cold Spring Harbor perspectives in biology.

[4]  Troy C. Krzysiak,et al.  Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling , 2016, Biochemistry.

[5]  Richard D Emes,et al.  A Trematode Parasite Derived Growth Factor Binds and Exerts Influences on Host Immune Functions via Host Cytokine Receptor Complexes , 2016, PLoS pathogens.

[6]  R. Maizels,et al.  Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths , 2015, Mucosal Immunology.

[7]  H. Fan,et al.  IL-25 promotes the function of CD4+CD25+ T regulatory cells and prolongs skin-graft survival in murine models. , 2015, International immunopharmacology.

[8]  R. Maizels,et al.  Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products , 2015, Journal of visualized experiments : JoVE.

[9]  W. Młynarski,et al.  Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up. , 2014, Clinical immunology.

[10]  Deepali V. Sawant,et al.  Once a Treg, always a Treg? , 2014, Immunological reviews.

[11]  Yat T. Tang,et al.  Genome of the human hookworm Necator americanus , 2014, Nature Genetics.

[12]  R. Maizels,et al.  Helminths and Immunological Tolerance , 2014, Transplantation.

[13]  D. Rifkin,et al.  Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation. , 2013, Cytokine & growth factor reviews.

[14]  R. Maizels,et al.  Helminth Infections and Host Immune Regulation , 2012, Clinical Microbiology Reviews.

[15]  Wenqing Cai,et al.  Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. , 2012, Cell Stem Cell.

[16]  J. Lafaille,et al.  Induced CD4+Foxp3+ regulatory T cells in immune tolerance. , 2012, Annual review of immunology.

[17]  D. Tran TGF-β: the sword, the wand, and the shield of FOXP3(+) regulatory T cells. , 2012, Journal of molecular cell biology.

[18]  R. Maizels,et al.  Regulatory T Cells in Infection , 2011, Advances in Immunology.

[19]  T. Geary,et al.  Proteomic Analysis of Excretory-Secretory Products of Heligmosomoides polygyrus Assessed with Next-Generation Sequencing Transcriptomic Information , 2011, PLoS neglected tropical diseases.

[20]  M. Blaxter,et al.  Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins. , 2011, Journal of proteomics.

[21]  Charles P. Lin,et al.  Immune recognition and rejection of allogeneic skin grafts. , 2011, Immunotherapy.

[22]  A. Hinck,et al.  TGF‐β signalling is mediated by two autonomously functioning TβRI:TβRII pairs , 2011, The EMBO journal.

[23]  C. Loddenkemper,et al.  Strongyloides ratti Infection Induces Expansion of Foxp3+ Regulatory T Cells That Interfere with Immune Response and Parasite Clearance in BALB/c Mice , 2011, The Journal of Immunology.

[24]  A. Rudensky,et al.  Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway , 2010, The Journal of experimental medicine.

[25]  A. Hinck,et al.  Ternary Complex of Transforming Growth Factor-β1 Reveals Isoform-specific Ligand Recognition and Receptor Recruitment in the Superfamily* , 2010, The Journal of Biological Chemistry.

[26]  R. Maizels,et al.  daf-7-related TGF-β homologues from Trichostrongyloid nematodes show contrasting life-cycle expression patterns , 2009, Parasitology.

[27]  R. Dana,et al.  Levels of Foxp3 in Regulatory T Cells Reflect Their Functional Status in Transplantation1 , 2009, The Journal of Immunology.

[28]  R. Flavell,et al.  TGF-β: A Master of All T Cell Trades , 2008, Cell.

[29]  Chen Dong,et al.  Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. , 2008, Immunity.

[30]  A. Kulkarni,et al.  A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells , 2008, Nature Immunology.

[31]  Yuelei Shen,et al.  TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function , 2008, Nature.

[32]  C. Loddenkemper,et al.  Functional Analysis of Effector and Regulatory T Cells in a Parasitic Nematode Infection , 2008, Infection and Immunity.

[33]  A. Hinck,et al.  Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. , 2008, Molecular cell.

[34]  R. Maizels,et al.  Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection , 2007, European journal of immunology.

[35]  D. Elliott,et al.  Helminths as governors of immune-mediated inflammation. , 2007, International journal for parasitology.

[36]  S. Akira,et al.  TLR Engagement Prevents Transplantation Tolerance , 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[37]  H. Weiner,et al.  Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells , 2006, Nature.

[38]  P. Knaus,et al.  A member of the transforming growth factor-beta receptor family from Echinococcus multilocularis is activated by human bone morphogenetic protein 2. , 2006, Molecular and biochemical parasitology.

[39]  T. Wyss-Coray,et al.  Highly sensitive and specific bioassay for measuring bioactive TGF-β , 2006, BMC Cell Biology.

[40]  A. Hinck,et al.  Assembly of TβRI: TβRII:TGFβ ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependent , 2005 .

[41]  R. Maizels,et al.  Suppression of allergic airway inflammation by helminth-induced regulatory T cells , 2005, The Journal of experimental medicine.

[42]  R. Maizels,et al.  Removal of Regulatory T Cell Activity Reverses Hyporesponsiveness and Leads to Filarial Parasite Clearance In Vivo1 , 2005, The Journal of Immunology.

[43]  A. Rudensky,et al.  TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells , 2005, The Journal of experimental medicine.

[44]  A. Rudensky,et al.  Regulatory T cell lineage specification by the forkhead transcription factor foxp3. , 2005, Immunity.

[45]  R. Flavell,et al.  TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Li Li,et al.  Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 , 2003, The Journal of experimental medicine.

[47]  A. Hinck,et al.  Solution structure and backbone dynamics of the TGFbeta type II receptor extracellular domain. , 2003, Biochemistry.

[48]  A. Reith,et al.  SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. , 2002, Molecular pharmacology.

[49]  E. Pearce,et al.  Human Transforming Growth Factor-β Activates a Receptor Serine/Threonine Kinase from the Intravascular ParasiteSchistosoma mansoni * , 2001, The Journal of Biological Chemistry.

[50]  A. Mellor,et al.  Differential Susceptibility of Heart, Skin, and Islet Allografts to T Cell-Mediated Rejection1 , 2001, The Journal of Immunology.

[51]  C. Niehrs,et al.  Silencing of TGF-β signalling by the pseudoreceptor BAMBI , 1999, Nature.

[52]  J H Barker,et al.  Scoring of skin rejection in a swine composite tissue allograft model. , 1999, The Journal of surgical research.

[53]  M. Ferguson,et al.  Transforming growth factor–β3 is required for secondary palate fusion , 1995, Nature Genetics.

[54]  R. Kühn,et al.  IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma. , 1994, Journal of immunology.

[55]  D. Riddle,et al.  The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development , 1993, Nature.

[56]  J. Dasch,et al.  Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification. , 1989, Journal of immunology.

[57]  M. Sporn,et al.  Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[58]  P. Medawar,et al.  ACQUIRED TOLERANCE OF SKIN HOMOGRAFTS , 1955, Annals of the New York Academy of Sciences.

[59]  A. Hinck,et al.  Production, Isolation, and Structural Analysis of Ligands and Receptors of the TGF-β Superfamily. , 2016, Methods in molecular biology.

[60]  Antonio Alcami,et al.  Viral mimicry of cytokines, chemokines and their receptors , 2003, Nature Reviews Immunology.

[61]  P. Schatz,et al.  Biotinylation of proteins in vivo and in vitro using small peptide tags. , 2000, Methods in enzymology.

[62]  R. W. Padgett,et al.  TGFβ-related pathways: roles in Caenorhabditis elegans development , 2000 .

[63]  G. Boivin,et al.  TGF β 2 knockout mice have multiple developmental defects that are non-overlapping with other TGF β knockout phenotypes , 1997 .