Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity.

[1]  Shwetank,et al.  B Cell–Intrinsic CD84 and Ly108 Maintain Germinal Center B Cell Tolerance , 2015, The Journal of Immunology.

[2]  D. Rawlings,et al.  B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production. , 2015, Current opinion in immunology.

[3]  S. Akira,et al.  B Cell–Intrinsic TLR7 Signaling Is Essential for the Development of Spontaneous Germinal Centers , 2014, The Journal of Immunology.

[4]  A. Nakamura,et al.  Dichotomy in FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis , 2014, BMC Immunology.

[5]  S. Crotty T follicular helper cell differentiation, function, and roles in disease. , 2014, Immunity.

[6]  Hai Qi,et al.  T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction , 2014, Nature.

[7]  R. Brink The imperfect control of self-reactive germinal center B cells. , 2014, Current opinion in immunology.

[8]  C. Alpers,et al.  Opposing Impact of B Cell–Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic Inflammation , 2014, The Journal of Immunology.

[9]  D. Green,et al.  Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells , 2014, The Journal of Immunology.

[10]  J. Ravetch,et al.  Inhibitory Fcγ Receptor Is Required for the Maintenance of Tolerance through Distinct Mechanisms , 2014, The Journal of Immunology.

[11]  Uri Hershberg,et al.  Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation , 2014, The Journal of experimental medicine.

[12]  C. Pusey,et al.  FcγRIIb on Myeloid Cells and Intrinsic Renal Cells Rather than B Cells Protects from Nephrotoxic Nephritis , 2013, The Journal of Immunology.

[13]  C. Mohan,et al.  The Lupus-Prone NZM2410/NZW Strain–Derived Sle1b Sublocus Alters the Germinal Center Checkpoint in Female Mice in a B Cell–Intrinsic Manner , 2012, The Journal of Immunology.

[14]  Diego G. Silva,et al.  Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers. , 2012, Immunity.

[15]  C. Melief,et al.  Fcγ Receptor IIb Strongly Regulates Fcγ Receptor-Facilitated T Cell Activation by Dendritic Cells , 2012, The Journal of Immunology.

[16]  D. Tarlinton,et al.  Determining germinal centre B cell fate. , 2012, Trends in immunology.

[17]  J. Ravetch,et al.  Mouse model recapitulating human Fcγ receptor structural and functional diversity , 2012, Proceedings of the National Academy of Sciences.

[18]  M. Ono,et al.  Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcγ receptor type IIb-deficient C57BL/6 genetic background. , 2011, Arthritis and rheumatism.

[19]  D. Kitamura,et al.  In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo. , 2011, Nature communications.

[20]  J. Ravetch,et al.  Inhibitory Fcγ Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies , 2011, Science.

[21]  M. Rastaldi,et al.  The Inhibiting Fc Receptor for IgG, FcγRIIB, Is a Modifier of Autoimmune Susceptibility , 2011, The Journal of Immunology.

[22]  K. Ikeda,et al.  Susceptibility loci for the defective foreign protein‐induced tolerance in New Zealand Black mice: Implication of epistatic effects of Fcgr2b and Slam family genes , 2011, European journal of immunology.

[23]  S. Tangye,et al.  SLAM family receptors and SAP adaptors in immunity. , 2011, Annual review of immunology.

[24]  E. Wakeland,et al.  The role of SLAM/CD2 polymorphisms in systemic autoimmunity. , 2010, Current opinion in immunology.

[25]  T. Tiller,et al.  Development of self-reactive germinal center B cells and plasma cells in autoimmune FcγRIIB-deficient mice , 2010, The Journal of experimental medicine.

[26]  Kenneth G. C. Smith,et al.  FcγRIIB in autoimmunity and infection: evolutionary and therapeutic implications , 2010, Nature Reviews Immunology.

[27]  R. Germain,et al.  Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. , 2010, Immunity.

[28]  L. Erickson,et al.  Development of Murine Lupus Involves the Combined Genetic Contribution of the SLAM and FcγR Intervals within the Nba2 Autoimmune Susceptibility Locus , 2009, The Journal of Immunology.

[29]  T. Manser,et al.  The Lupus Susceptibility Locus Sle1 Breaches Peripheral B Cell Tolerance at the Antibody-Forming Cell and Germinal Center Checkpoints1 , 2009, The Journal of Immunology.

[30]  Hedda Wardemann,et al.  B-cell tolerance checkpoints in health and autoimmunity. , 2008, Current opinion in immunology.

[31]  Maria R. Gumina,et al.  Cutting Edge: IL-4-Mediated Protection of Primary B Lymphocytes from Apoptosis via Stat6-Dependent Regulation of Glycolytic Metabolism1 , 2007, The Journal of Immunology.

[32]  T. Manser,et al.  Expression of the autoimmune Fcgr2b NZW allele fails to be upregulated in germinal center B cells and is associated with increased IgG production , 2007, Genes and Immunity.

[33]  T. Manser,et al.  Quantitatively Reduced Participation of Anti-Nuclear Antigen B Cells That Down-Regulate B Cell Receptor during Primary Development in the Germinal Center/Memory B Cell Response to Foreign Antigen1 , 2007, The Journal of Immunology.

[34]  M. Walport,et al.  Genetic Dissection of Spontaneous Autoimmunity Driven by 129-Derived Chromosome 1 Loci When Expressed on C57BL/6 Mice1 , 2007, The Journal of Immunology.

[35]  S. Itohara,et al.  Germinal Center Marker GL7 Probes Activation-Dependent Repression of N-Glycolylneuraminic Acid, a Sialic Acid Species Involved in the Negative Modulation of B-Cell Activation , 2007, Molecular and Cellular Biology.

[36]  T. Manser,et al.  FcγRIIB Regulates Autoreactive Primary Antibody-Forming Cell, but Not Germinal Center B Cell, Activity1 , 2007, The Journal of Immunology.

[37]  T. Chiles,et al.  Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. , 2006, Blood.

[38]  B. Kotzin,et al.  Effects of MHC and Gender on Lupus-Like Autoimmunity in Nba2 Congenic Mice1 , 2005, The Journal of Immunology.

[39]  T. Manser,et al.  Failed Up-Regulation of the Inhibitory IgG Fc Receptor FcγRIIB on Germinal Center B Cells in Autoimmune-Prone Mice Is Not Associated with Deletion Polymorphisms in the Promoter Region of the FcγRIIB Gene , 2005, The Journal of Immunology.

[40]  A. Pertsemlidis,et al.  Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. , 2004, Immunity.

[41]  M. Walport,et al.  Open access, freely available online PLoS BIOLOGY Spontaneous Autoimmunity in 129 and C57BL/6 Mice—Implications for Autoimmunity Described in Gene-Targeted Mice , 2022 .

[42]  A. Veillette SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors , 2004, The Journal of experimental medicine.

[43]  T. Manser,et al.  Progressive Surface B Cell Antigen Receptor Down-Regulation Accompanies Efficient Development of Antinuclear Antigen B Cells to Mature, Follicular Phenotype1 , 2004, The Journal of Immunology.

[44]  L. Erickson,et al.  A genetic lesion that arrests plasma cell homing to the bone marrow , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[45]  S. Latour,et al.  The SLAM family of immune-cell receptors. , 2003, Current opinion in immunology.

[46]  T. Manser,et al.  Dominant, hierarchical induction of peripheral tolerance during foreign antigen-driven B cell development. , 2002, Immunity.

[47]  T. Behrens,et al.  Delineating the genetic basis of systemic lupus erythematosus. , 2001, Immunity.

[48]  K. Blenman,et al.  The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[49]  J. Ravetch,et al.  Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis. , 2000, Immunity.

[50]  E. Wakeland,et al.  Genetic dissection of systemic lupus erythematosus. , 1999, Current opinion in immunology.

[51]  M. Petri,et al.  Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[52]  T. Kurosaki,et al.  SHIP modulates immune receptor responses by regulating membrane association of Btk. , 1998, Immunity.

[53]  C. Mohan,et al.  Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes. , 1998, The Journal of clinical investigation.

[54]  R. Cantor,et al.  Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus. , 1997, The Journal of clinical investigation.

[55]  C. Drake,et al.  Effect of genetic background on the contribution of New Zealand black loci to autoimmune lupus nephritis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[56]  M. Ono,et al.  Augmented humoral and anaphylactic responses in FcγRII-deficient mice , 1996, Nature.

[57]  林崎 綾,et al.  Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcγ receptor type IIb-deficient C57BL/6 genetic background , 2012 .

[58]  J. Ravetch,et al.  Fcgamma receptors as regulators of immune responses. , 2008, Nature reviews. Immunology.

[59]  J. Ravetch,et al.  Fcγ receptors as regulators of immune responses , 2008, Nature Reviews Immunology.

[60]  J. Ravetch,et al.  Fcgamma receptors: old friends and new family members. , 2006, Immunity.

[61]  E. Wakeland,et al.  Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease. , 2006, Advances in immunology.

[62]  J. Ravetch,et al.  Fcgamma receptors: old friends and new family members. , 2006, Immunity.

[63]  J. Ravetch,et al.  Inhibitory pathways triggered by ITIM-containing receptors. , 1999, Advances in immunology.

[64]  M. Ono,et al.  Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. , 1996, Nature.

[65]  Thomas L. Rothstein,et al.  The role of clonal selection and somatic mutation in autoimmunity , 1987, Nature.