Deletion of the LuxR-type regulator VjbR in Brucella canis affects expression of type IV secretion system and bacterial virulence, and the mutant strain confers protection against Brucella canis challenge in mice.

[1]  L. Stranahan,et al.  Characterization of Brucella canis infection in mice , 2019, PloS one.

[2]  Q. Gao,et al.  RNA-seq reveals the critical role of Lon protease in stress response and Brucella virulence. , 2019, Microbial pathogenesis.

[3]  Hui Zhang,et al.  Development and evaluation of in murine model, of an improved live-vaccine candidate against brucellosis from to Brucella melitensis vjbR deletion mutant. , 2018, Microbial pathogenesis.

[4]  M. Hensel,et al.  Brucellosis in Dogs and Public Health Risk , 2018, Emerging infectious diseases.

[5]  C. Guzmán-Verri,et al.  Brucella abortus Senses the Intracellular Environment through the BvrR/BvrS Two-Component System, Which Allows B. abortus To Adapt to Its Replicative Niche , 2018, Infection and Immunity.

[6]  Xiao-wei Peng,et al.  Rough brucella strain RM57 is attenuated and confers protection against Brucella melitensis. , 2017, Microbial pathogenesis.

[7]  Xinglong Wang,et al.  A safe and molecular-tagged Brucella canis ghosts confers protection against virulent challenge in mice. , 2017, Veterinary microbiology.

[8]  C. Ding,et al.  Characterization of Brucella abortus mutant strain Δ22915, a potential vaccine candidate , 2017, Veterinary Research.

[9]  C. Kleinman,et al.  ChIP-seq analysis of the LuxR-type regulator VjbR reveals novel insights into the Brucella virulence gene expression network , 2017, Nucleic acids research.

[10]  A. Whatmore,et al.  Extended Multilocus Sequence Analysis to Describe the Global Population Structure of the Genus Brucella: Phylogeography and Relationship to Biovars , 2016, Front. Microbiol..

[11]  X. Suo,et al.  Brucella suis strain 2 vaccine is safe and protective against heterologous Brucella spp. infections. , 2016, Vaccine.

[12]  C. Guzmán-Verri,et al.  Brucella canis Is an Intracellular Pathogen That Induces a Lower Proinflammatory Response than Smooth Zoonotic Counterparts , 2015, Infection and Immunity.

[13]  M. Delpino,et al.  Immunization with Brucella VirB Proteins Reduces Organ Colonization in Mice through a Th1-Type Immune Response and Elicits a Similar Immune Response in Dogs , 2014, Clinical and Vaccine Immunology.

[14]  G. Gray,et al.  Evidence for Unapparent Brucella canis Infections among Adults with Occupational Exposure to Dogs , 2014, Zoonoses and public health.

[15]  M. Palmer,et al.  Advancement of Knowledge of Brucella Over the Past 50 Years , 2014, Veterinary pathology.

[16]  F. Goldbaum,et al.  The vaccine candidate BLSOmp31 protects mice against Brucella canis infection. , 2013, Vaccine.

[17]  J. V. van Dijl,et al.  Sensing of Bacterial Type IV Secretion via the Unfolded Protein Response , 2013, mBio.

[18]  M. D. de Miguel,et al.  Quorum-Sensing and BvrR/BvrS Regulation, the Type IV Secretion System, Cyclic Glucans, and BacA in the Virulence of Brucella ovis: Similarities to and Differences from Smooth Brucellae , 2012, Infection and Immunity.

[19]  Yufei Wang,et al.  The 16MΔvjbR as an ideal live attenuated vaccine candidate for differentiation between Brucella vaccination and infection. , 2011, Veterinary microbiology.

[20]  J. Lemaire,et al.  Global Analysis of Quorum Sensing Targets in the Intracellular Pathogen Brucella melitensis 16 M , 2010, Journal of Proteome Research.

[21]  S. Boyle,et al.  Brucellosis: a re-emerging zoonosis. , 2010, Veterinary microbiology.

[22]  H. Garner,et al.  Brucella melitensis VjbR and C12-HSL regulons: contributions of the N-dodecanoyl homoserine lactone signaling molecule and LuxR homologue VjbR to gene expression , 2010, BMC Microbiology.

[23]  M. Almuzara,et al.  Human Brucella canis outbreak linked to infection in dogs , 2009, Epidemiology and Infection.

[24]  J. V. van Dijl,et al.  Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by the Brucella type IV secretion system , 2008, Molecular microbiology.

[25]  T. Ficht,et al.  The Brucella abortus S19 ΔvjbR Live Vaccine Candidate Is Safer than S19 and Confers Protection against Wild-Type Challenge in BALB/c Mice When Delivered in a Sustained-Release Vehicle , 2008, Infection and Immunity.

[26]  J. Lemaire,et al.  Mutations of the Quorum Sensing-Dependent Regulator VjbR Lead to Drastic Surface Modifications in Brucella melitensis , 2007, Journal of bacteriology.

[27]  T. Ficht,et al.  Evaluation of Protection Afforded by Brucella abortus and Brucella melitensis Unmarked Deletion Mutants Exhibiting Different Rates of Clearance in BALB/c Mice , 2006, Infection and Immunity.

[28]  S. Olsen,et al.  Essential role of vaccines in brucellosis control and eradication programs for livestock , 2005, Expert review of vaccines.

[29]  J. Letesson,et al.  A quorum‐sensing regulator controls expression of both the type IV secretion system and the flagellar apparatus of Brucella melitensis , 2005, Cellular microbiology.

[30]  S. Shin,et al.  Canine brucellosis: a diagnostician's dilemma. , 1996, Seminars in veterinary medicine and surgery.

[31]  J. Feeley,et al.  Human disease caused by Brucella canis. A clinical and epidemiologic study of two cases. , 1975, JAMA.