RandomiSed clinical trial assessing Use of an anti-inflammatoRy aGent in attenUating peri-operatiVe inflAmmatioN in non-meTastatic colon cancer – the S.U.R.G.U.V.A.N.T. trial

[1]  M. Kerin,et al.  The Impact of Surgical Complications on Cancer Recurrence Rates: A Literature Review , 2018, Oncology Research and Treatment.

[2]  A. Bhatt,et al.  Role of interleukin-6 in cancer progression and therapeutic resistance , 2016, Tumor Biology.

[3]  D. O'Leary,et al.  Effects of surgery on the cancer stem cell niche. , 2016, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[4]  D. O'Leary,et al.  Influence of complications following immediate breast reconstruction on breast cancer recurrence rates , 2016, The British journal of surgery.

[5]  Yinglong Zhang,et al.  Interleukin-6 suppression reduces tumour self-seeding by circulating tumour cells in a human osteosarcoma nude mouse model , 2015, Oncotarget.

[6]  D. O’Leary,et al.  A meta‐analysis to determine the oncological implications of conversion in laparoscopic colorectal cancer surgery , 2015, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[7]  L. Kirkeby,et al.  High interleukin-6 mRNA expression is a predictor of relapse in colon cancer. , 2015, Anticancer Research.

[8]  D. McMillan,et al.  Comparison of the prognostic value of longitudinal measurements of systemic inflammation in patients undergoing curative resection of colorectal cancer , 2013, British Journal of Cancer.

[9]  H. Redmond,et al.  Laparotomy and laparoscopy diversely affect macrophage-associated antimicrobial activity in a murine model , 2013, BMC Immunology.

[10]  D. McMillan,et al.  Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer , 2013, British Journal of Cancer.

[11]  H. Ripps,et al.  Review: Taurine: A “very essential” amino acid , 2012, Molecular vision.

[12]  D. O'Leary,et al.  TLR-4 Signalling Accelerates Colon Cancer Cell Adhesion via NF-κB Mediated Transcriptional Up-Regulation of Nox-1 , 2012, PloS one.

[13]  D. O'Leary,et al.  Less stress, more success? Oncological implications of surgery-induced oxidative stress , 2011, Gut.

[14]  T. Cotter,et al.  Surgical Injury Enhances the Expression of Genes That Mediate Breast Cancer Metastasis to the Lung , 2010, Annals of surgery.

[15]  H. Redmond,et al.  The antiendotoxin agent taurolidine potentially reduces ischemia/reperfusion injury through its metabolite taurine. , 2010, Surgery.

[16]  H. Redmond,et al.  The Evolving Role of Taurolidine in Cancer Therapy , 2010, Annals of Surgical Oncology.

[17]  Larry Norton,et al.  Tumor Self-Seeding by Circulating Cancer Cells , 2009, Cell.

[18]  J. Wind,et al.  Circulating tumour cells during laparoscopic and open surgery for primary colonic cancer in portal and peripheral blood. , 2009, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[19]  A. Darzi,et al.  Does the Presence of Circulating Tumor Cells in the Venous Drainage of Curative Colorectal Cancer Resections Determine Prognosis? A Meta-Analysis , 2008, Annals of Surgical Oncology.

[20]  H. Redmond,et al.  Taurolidine induces apoptosis of murine melanoma cells in vitro and in vivo by modulation of the Bcl‐2 family proteins , 2007, Journal of surgical oncology.

[21]  J. Wang,et al.  Inhibition of urokinase plasminogen activator with a novel enzyme inhibitor, wxc-340, ameliorates endotoxin and surgery-accelerated growth of murine metastases , 2007, British Journal of Cancer.

[22]  H. Redmond,et al.  Cell response to surgery. , 2006, Archives of surgery.

[23]  T. Cotter,et al.  Cancer surgery: risks and opportunities , 2006, BioEssays : news and reviews in molecular, cellular and developmental biology.

[24]  J. Wang,et al.  Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-κB-dependent activation of the urokinase plasminogen activator system , 2006, British Journal of Cancer.

[25]  T. Cotter,et al.  The Targeting of Phosphoinositide-3 Kinase Attenuates Pulmonary Metastatic Tumor Growth Following Laparotomy , 2006, Annals of surgery.

[26]  H. Redmond,et al.  Can surgery for cancer accelerate the progression of secondary tumors within residual minimal disease at both local and systemic levels? , 2005, The Annals of thoracic surgery.

[27]  T. Cotter,et al.  Phosphoinositide 3-Kinase Accelerates Postoperative Tumor Growth by Inhibiting Apoptosis and Enhancing Resistance to Chemotherapy-induced Apoptosis , 2005, Journal of Biological Chemistry.

[28]  H. Redmond,et al.  Surgically induced accelerated local and distant tumor growth is significantly attenuated by selective COX-2 inhibition. , 2005, The Annals of thoracic surgery.

[29]  T G Cotter,et al.  Excisional surgery for cancer cure: therapy at a cost. , 2003, The Lancet. Oncology.

[30]  H. Redmond,et al.  Endotoxin/Lipopolysaccharide Activates NF-κB and Enhances Tumor Cell Adhesion and Invasion Through a β1 Integrin-Dependent Mechanism , 2003, The Journal of Immunology.

[31]  H. Redmond,et al.  Taurolidine improves survival by abrogating the accelerated development and proliferation of solid tumors and development of organ metastases from circulating tumor cells released following surgery. , 2001, The Journal of surgical research.

[32]  A. Lacy,et al.  Acute phase response in laparoscopic and open colectomy in colon cancer , 2001, Diseases of the colon and rectum.

[33]  H. Redmond,et al.  Taurolidine Inhibits Tumor Cell Growth In Vitro and In Vivo , 2000, Annals of Surgical Oncology.

[34]  A. Darzi,et al.  Beneficial effects of taurolidine in experimental pancreatitis. , 1994, Journal of Surgical Research.

[35]  I. Bedrosian,et al.  Taurolidine, an analogue of the amino acid taurine, suppresses interleukin 1 and tumor necrosis factor synthesis in human peripheral blood mononuclear cells. , 1991, Cytokine.

[36]  J. Wang,et al.  Laparoscopic surgery protects against the oncologic adverse effects of open surgery by attenuating endothelial progenitor cell mobilization , 2005, Surgical Endoscopy.

[37]  H. Redmond,et al.  Endotoxin/lipopolysaccharide activates NF-kappa B and enhances tumor cell adhesion and invasion through a beta 1 integrin-dependent mechanism. , 2003, Journal of immunology.