Laser driven short-term thermal angioplasty: enhancement of drug delivery performance by heating with tension

To enhance drug delivery performance of drug eluting balloon (DEB) against re-stenosis, we have proposed a heating drug delivery during balloon dilatation using our laser driven short-term thermal angioplasty which may realize to suppress surrounding thermal injury. We studied an influence of vessel dilatation parameters on the heating drug delivery. These parameters were classified into two different forces, that is, circumferential tension and inter-luminal pressure. We think these parameters were not able to determine only by balloon pressure. The circumferential tension with 0—30 mN/mm2 was added to a porcine carotid artery using an automatic stage. Various temperature solutions with 37, and 70°C of hydrophobic fluorescent Rhodamine B with 3 μg/ml in concentration were dropped on pig carotid wall. We measured a defined drug delivery amount as well as delivery depth by a microscopic fluorescence measurement on the cross section of the solution delivered vessel. In the case of 37°C, we found the intima surface drug amount with 7 mN/mm2 was increased as 10-20 times as other tension cases. On the other hand, at 70°C, we found the optimum tension with 30 mN/mm2. We found the drug delivery enhancement might be related to the change of super microscopic surface structure of the vessel. We predict that the collagen thermal denaturation of the vessel wall might play important role to the drug delivery.

[1]  B F Waller,et al.  Radiofrequency balloon angioplasty. Rationale and proof of principle. , 1988, Investigative radiology.

[2]  Johannes Lammer,et al.  Balloon angioplasty versus stenting with nitinol stents in intermediate length superficial femoral artery lesions , 2009, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[3]  Natsumi Shimazaki,et al.  The laser driven heating balloon catheter: Vessel dilatation characteristics , 2008, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[4]  Xiomara Calderon-Colon,et al.  Thermal denaturation of type I collagen vitrified gels , 2012 .

[5]  R. D. Jenkins,et al.  Laser balloon angioplasty: clinical, angiographic and histologic results. , 1991, Journal of the American College of Cardiology.

[6]  D. Mozaffarian,et al.  Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2009, Circulation.

[7]  Tsunenori Arai,et al.  Acute effects of short-term intimal heating by laser-heated thermal balloon angioplasty in canine stenotic femoral arteries in vivo , 1993, Photonics West - Lasers and Applications in Science and Engineering.

[8]  Masataka Nakano,et al.  Vascular, downstream, and pharmacokinetic responses to treatment with a low dose drug‐coated balloon in a swine femoral artery model , 2014, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[9]  Giuseppe Biondi-Zoccai,et al.  Paclitaxel-Coated Balloons Reduce Restenosis After Femoro-Popliteal Angioplasty , 2012 .

[10]  Seiki Nagata,et al.  Effect of exercise on frequency of stent fracture in the superficial femoral artery. , 2006, The American journal of cardiology.

[11]  Natsumi Shimazaki,et al.  Heating drug delivery to vascular wall with Rhodamine B and fluorescence labeled Paclitaxel ranging 50 to 70°C: ex vivo study , 2016, SPIE BiOS.

[12]  J. Spears,et al.  Percutaneous transluminal coronary angioplasty restenosis: potential prevention with laser balloon angioplasty. , 1987, The American journal of cardiology.

[13]  N. Fineberg,et al.  Vascular injury, repair, and restenosis after percutaneous transluminal angioplasty in the atherosclerotic rabbit. , 1995, Circulation.

[14]  D. Mozaffarian,et al.  Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2009, Circulation.

[15]  V. Fuster,et al.  Inhibition of tissue factor reduces thrombus formation and intimal hyperplasia after porcine coronary angioplasty. , 2000, Journal of the American College of Cardiology.

[16]  E. Edelman,et al.  Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[17]  V. Fuster,et al.  Balloon angioplasty. Natural history of the pathophysiological response to injury in a pig model. , 1985, Circulation research.