Using scores derived from statistical coupling analysis to distinguish correct and incorrect folds in de‐novo protein structure prediction

Distinguishing native from non‐native folds remains a challenging problem for protein structure prediction. We describe a method, SCA‐distance scoring, based on results from statistical coupling analysis which discriminates between native and non‐native folds produced by a de novo protein structure prediction method for four out of five test proteins. The method is particularly good at discriminating non‐native folds which are close in RMSD to the true fold but contain a change in an internal structural element. SCA‐distance scoring is a useful addition to the tools available for distinguishing native from non‐native folds in protein structure prediction. Proteins 2008. © 2007 Wiley‐Liss, Inc.

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