Transcription by RNA polymerase I.

The genes that code for 45S rRNA, the precursor of 18S, 5.8S and 28S rRNA, are transcribed by RNA polymerase I. In many eukaryotes the genes are arranged as tandem repeats in discrete chromosomal clusters. rDNA transcription and rRNA processing occur in the nucleolus. In vertebrates, at least two factors, SL-1 and UBF, specific for transcription by RNA polymerase I cooperate in the formation of the initiation complex. Interestingly, there are proteins analogous to SL-1 in unicellular eukaryotes, but the requirement for a UBF-like factor appears to vary. Recent advances in our understanding of the rDNA transcription system and its regulation have demonstrated overlap with the other nuclear transcription systems (RNA polymerase II and III). This is exemplified by the utilization of TBP as a component of SL-1 and the role of Rb in regulatory rDNA transcription.

[1]  R. Hannan,et al.  Affinity Purification of Mammalian RNA Polymerase I , 1998, The Journal of Biological Chemistry.

[2]  G. Geiss,et al.  The Fundamental Ribosomal RNA Transcription Initiation Factor-IB (TIF-IB, SL1, Factor D) Binds to the rRNA Core Promoter Primarily by Minor Groove Contacts* , 1997, The Journal of Biological Chemistry.

[3]  D. Hernandez-Verdun,et al.  When rDNA transcription is arrested during mitosis, UBF is still associated with non-condensed rDNA. , 1997, Journal of cell science.

[4]  I. Grummt,et al.  Constitutive and strong association of PAF53 with RNA polymerase I , 1997, Chromosoma.

[5]  F. Grummt,et al.  Termination of Mammalian rDNA Replication: Polar Arrest of Replication Fork Movement by Transcription Termination Factor TTF-I , 1997, Cell.

[6]  I. Grummt,et al.  Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein , 1997, Molecular and cellular biology.

[7]  L. Comai,et al.  SV40 large T antigen binds to the TBP-TAF(I) complex SL1 and coactivates ribosomal RNA transcription. , 1997, Genes & development.

[8]  P. Thuriaux,et al.  A34.5, a nonessential component of yeast RNA polymerase I, cooperates with subunit A14 and DNA topoisomerase I to produce a functional rRNA synthesis machine , 1997, Molecular and cellular biology.

[9]  S. Jacob,et al.  Regulation of ribosomal RNA gene transcription during retinoic acid-induced differentiation of mouse teratocarcinoma cells. , 1997, Experimental cell research.

[10]  G. Längst,et al.  RNA polymerase I transcription on nucleosomal templates: the transcription termination factor TTF‐I induces chromatin remodeling and relieves transcriptional repression , 1997, The EMBO journal.

[11]  B. Bartholomew,et al.  Identification of Previously Unrecognized Common Elements in Eukaryotic Promoters , 1997, The Journal of Biological Chemistry.

[12]  S. Jacob,et al.  The dual role of helix – loop – helix-zipper protein USF in ribosomal RNA gene transcription in vivo , 1997, Oncogene.

[13]  G. Längst,et al.  Structural analysis of mouse rDNA: coincidence between nuclease hypersensitive sites, DNA curvature and regulatory elements in the intergenic spacer. , 1997, Nucleic acids research.

[14]  B. McStay,et al.  The Xenopus RNA polymerase I transcription factor, UBF, has a role in transcriptional enhancement distinct from that at the promoter , 1997, The EMBO journal.

[15]  D. Hernandez-Verdun,et al.  Involvement of in situ conformation of ribosomal genes and selective distribution of upstream binding factor in rRNA transcription. , 1997, Molecular biology of the cell.

[16]  I. Grummt,et al.  Identification of a transcript release activity acting on ternary transcription complexes containing murine RNA polymerase I , 1997, The EMBO journal.

[17]  Y. Nogi,et al.  Mouse RNA Polymerase I 16-kDa Subunit Able to Associate with 40-kDa Subunit Is a Homolog of Yeast AC19 Subunit of RNA Polymerases I and III* , 1996, The Journal of Biological Chemistry.

[18]  L. Taylor,et al.  Androgen regulation of ribosomal RNA synthesis in LNCaP cells and rat prostate , 1996, The Journal of Steroid Biochemistry and Molecular Biology.

[19]  K. Mitomo,et al.  A novel 66-kilodalton protein complexes with Rrn6, Rrn7, and TATA-binding protein to promote polymerase I transcription initiation in Saccharomyces cerevisiae , 1996, Molecular and cellular biology.

[20]  M. Nomura,et al.  The role of TBP in rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae: TBP is required for upstream activation factor-dependent recruitment of core factor. , 1996, Genes & development.

[21]  D. Lalo,et al.  RRN11 Encodes the Third Subunit of the Complex Containing Rrn6p and Rrn7p That Is Essential for the Initiation of rDNA Transcription by Yeast RNA Polymerase I* , 1996, The Journal of Biological Chemistry.

[22]  S. Jacob,et al.  Rat ribosomal RNA gene can utilize primate RNA polymerase I transcription machinery: lack of absolute species specificity in rDNA transcription. , 1996, Biochemical and biophysical research communications.

[23]  R. Hannan,et al.  Overexpression of the transcription factor UBF1 is sufficient to increase ribosomal DNA transcription in neonatal cardiomyocytes: implications for cardiac hypertrophy. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Y. Nogi,et al.  RRN3 gene of Saccharomyces cerevisiae encodes an essential RNA polymerase I transcription factor which interacts with the polymerase independently of DNA template. , 1996, The EMBO journal.

[25]  E. Kuff,et al.  Intracellular redistribution of Ku immunoreactivity in response to cell-cell contact and growth modulating components in the medium. , 1996, Journal of cell science.

[26]  S. Dimitrov,et al.  Histones Associated with Non-nucleosomal Rat Ribosomal Genes Are Acetylated while Those Bound to Nucleosome-organized Gene Copies Are Not (*) , 1996, The Journal of Biological Chemistry.

[27]  K. Yamamoto,et al.  RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. , 1996, The EMBO journal.

[28]  D. Hernandez-Verdun,et al.  The rDNA transcription machinery is assembled during mitosis in active NORs and absent in inactive NORs , 1996, The Journal of cell biology.

[29]  M. Mannervik,et al.  In vivo evidence that TATA-binding protein/SL1 colocalizes with UBF and RNA polymerase I when rRNA synthesis is either active or inactive , 1996, The Journal of cell biology.

[30]  Y. Nogi,et al.  Multiprotein transcription factor UAF interacts with the upstream element of the yeast RNA polymerase I promoter and forms a stable preinitiation complex. , 1996, Genes & development.

[31]  J. Cheung,et al.  Regulation of rDNA transcription during endothelin-1-induced hypertrophy of neonatal cardiomyocytes. Hyperphosphorylation of upstream binding factor, an rDNA transcription factor. , 1996, Circulation research.

[32]  R. Hannan,et al.  Regulation of Ribosomal DNA Transcription during Contraction-induced Hypertrophy of Neonatal Cardiomyocytes (*) , 1996, The Journal of Biological Chemistry.

[33]  R. Hannan,et al.  The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor , 1996, Molecular and cellular biology.

[34]  R. Tjian,et al.  Coactivator and Promoter-Selective Properties of RNA Polymerase I TAFs , 1995, Science.

[35]  R. Reeder,et al.  The release element of the yeast polymerase I transcription terminator can function independently of Reb1p , 1995, Molecular and cellular biology.

[36]  T. Haystead,et al.  Angiotensin II-induced Hypertrophy of Rat Vascular Smooth Muscle Is Associated with Increased 18 S rRNA Synthesis and Phosphorylation of the rRNA Transcription Factor, Upstream Binding Factor (*) , 1995, The Journal of Biological Chemistry.

[37]  R. Reeder,et al.  Transcription termination of RNA polymerase I due to a T-rich element interacting with Reb1p. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[38]  R. Hannan,et al.  Regulation of ribosomal DNA transcription during neonatal cardiomyocyte hypertrophy. , 1995, Cardiovascular research.

[39]  G. Geiss,et al.  Site-directed photo-cross-linking of rRNA transcription initiation complexes , 1995, Molecular and cellular biology.

[40]  U. Scheer,et al.  A possible mechanism for the inhibition of ribosomal RNA gene transcription during mitosis , 1995, The Journal of cell biology.

[41]  R. Hannan,et al.  Regulation of rDNA Transcription Factors during Cardiomyocyte Hypertrophy Induced by Adrenergic Agents (*) , 1995, The Journal of Biological Chemistry.

[42]  P. Labhart.  DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[43]  S. Jacob.  Regulation of ribosomal gene transcription. , 1995, The Biochemical journal.

[44]  L. Taylor,et al.  Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product , 1995, Nature.

[45]  R. Hannan,et al.  The RNA Polymerase I Transcription Factor UBF Is the Product of a Primary Response Gene (*) , 1995, The Journal of Biological Chemistry.

[46]  I. Grummt,et al.  Different domains of the murine RNA polymerase I‐specific termination factor mTTF‐I serve distinct functions in transcription termination. , 1995, The EMBO journal.

[47]  S. Jackson,et al.  DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I. , 1995, Genes & development.

[48]  S. Jacob,et al.  E1BF/Ku interacts physically and functionally with the core promoter binding factor CPBF and promotes the basal transcription of rat and human ribosomal RNA genes. , 1995, Gene expression.

[49]  G. Geiss,et al.  Acanthamoeba castellanii contains a ribosomal RNA enhancer binding protein which stimulates TIF-IB binding and transcription under stringent conditions. , 1995, Nucleic acids research.

[50]  B. McStay,et al.  HMG box 4 is the principal determinant of species specificity in the RNA polymerase I transcription factor UBF. , 1995, Nucleic acids research.

[51]  R. Tjian,et al.  Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. , 1994, Science.

[52]  R. Tjian,et al.  Assembly of transcriptionally active RNA polymerase I initiation factor SL1 from recombinant subunits. , 1994, Science.

[53]  M. Muramatsu,et al.  Regulation of mouse UBF gene by multiple growth-related control elements. , 1994, Biochemical and biophysical research communications.

[54]  M. Green,et al.  The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein. , 1994, The Journal of biological chemistry.

[55]  J. Steitz,et al.  Organization of small nucleolar ribonucleoproteins (snoRNPs) by fluorescence in situ hybridization and immunocytochemistry. , 1994, Molecular biology of the cell.

[56]  Q. Ju,et al.  A model for transcription termination by RNA polymerase I , 1994, Cell.

[57]  K. Yamamoto,et al.  High conservation of subunit composition of RNA polymerase I(A) between yeast and mouse and the molecular cloning of mouse RNA polymerase I 40-kDa subunit RPA40. , 1994, The Journal of biological chemistry.

[58]  Y. Nogi,et al.  RRN6 and RRN7 encode subunits of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae. , 1994, Genes & development.

[59]  C. Pikaard,et al.  The RNA polymerase I transactivator upstream binding factor requires its dimerization domain and high-mobility-group (HMG) box 1 to bend, wrap, and positively supercoil enhancer DNA , 1994, Molecular and cellular biology.

[60]  A. Schnapp,et al.  TIF‐IC, a factor involved in both transcription initiation and elongation of RNA polymerase I. , 1994, The EMBO journal.

[61]  D. Eberhard,et al.  The conserved core domain of the human TATA binding protein is sufficient to assemble the multisubunit RNA polymerase I-specific transcription factor SL1. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[62]  Michael L. Denton,et al.  The RNA polymerase I transcription factor UBF is a sequence-tolerant HMG-box protein that can recognize structured nucleic acids , 1994, Nucleic Acids Res..

[63]  R. Brun,et al.  Factor C*, the specific initiation component of the mouse RNA polymerase I holoenzyme, is inactivated early in the transcription process , 1994, Molecular and cellular biology.

[64]  S. Jacob,et al.  Characterization of a protein that interacts with the rat ribosomal gene promoter and modulates RNA polymerase I transcription. , 1994, The Journal of biological chemistry.

[65]  D. Bazett-Jones,et al.  Short-range DNA looping by the Xenopus HMG-box transcription factor, xUBF. , 1994, Science.

[66]  B. McStay,et al.  xUBF, an RNA polymerase I transcription factor, binds crossover DNA with low sequence specificity , 1994, Molecular and cellular biology.

[67]  N. Zini,et al.  Discrete localization of different DNA topoisomerases in HeLa and K562 cell nuclei and subnuclear fractions. , 1994, Experimental cell research.

[68]  S. Jacob,et al.  Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[69]  C. Carles,et al.  The HMG box‐containing nucleolar transcription factor UBF interacts with a specific subunit of RNA polymerase I. , 1994, The EMBO journal.

[70]  A. Sentenac,et al.  TATA box-binding protein (TBP) is a constituent of the polymerase I-specific transcription initiation factor TIF-IB (SL1) bound to the rRNA promoter and shows differential sensitivity to TBP-directed reagents in polymerase I, II, and III transcription factors , 1994, Molecular and cellular biology.

[71]  M. Bianchi,et al.  Functional differences between the two splice variants of the nucleolar transcription factor UBF: the second HMG box determines specificity of DNA binding and transcriptional activity. , 1994, The EMBO journal.

[72]  R. Roeder,et al.  Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[73]  A. Schnapp,et al.  Function of the growth-regulated transcription initiation factor TIF-IA in initiation complex formation at the murine ribosomal gene promoter , 1993, Molecular and cellular biology.

[74]  M. Glibetić,et al.  Coordinated decreases in rRNA gene transcription factors and rRNA synthesis during muscle cell differentiation. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[75]  L. Tora,et al.  Sequence-specific transactivators counteract topoisomerase II-mediated inhibition of in vitro transcription by RNA polymerases I and II. , 1993, Nucleic acids research.

[76]  I. Grummt,et al.  The nucleolar transcription activator UBF relieves Ku antigen-mediated repression of mouse ribosomal gene transcription. , 1993, Nucleic acids research.

[77]  C. Kahn,et al.  Insulin induces the phosphorylation of nucleolin. A possible mechanism of insulin-induced RNA efflux from nuclei. , 1993, The Journal of biological chemistry.

[78]  S. Jacob,et al.  Characterization of the 130-bp repeat enhancer element of the rat ribosomal gene: functional interaction with transcription factor E1BF. , 1993, Gene.

[79]  S. Jacob,et al.  Characterization of the factor E1BF from a rat hepatoma that modulates ribosomal RNA gene transcription and its relationship to the human Ku autoantigen. , 1993, Biochemical and biophysical research communications.

[80]  M. Muramatsu,et al.  Presence of an inhibitor of RNA polymerase I mediated transcription in extracts from growth arrested mouse cells. , 1993, Nucleic acids research.

[81]  T. Moss,et al.  Recognition of the Xenopus ribosomal core promoter by the transcription factor xUBF involves multiple HMG box domains and leads to an xUBF interdomain interaction. , 1993, The EMBO journal.

[82]  D. Hernandez-Verdun,et al.  Localization of the RNA polymerase I transcription factor hUBF during the cell cycle. , 1993, Journal of cell science.

[83]  K. V. van Holde,et al.  Binding of the RNA polymerase I transcription complex to its promoter can modify positioning of downstream nucleosomes assembled in vitro. , 1993, The Journal of biological chemistry.

[84]  A. Levine.  The tumor suppressor genes. , 1993, Annual review of biochemistry.

[85]  S. Smith,et al.  Transcription from the rat 45S ribosomal DNA promoter does not require the factor UBF. , 1993, Gene expression.

[86]  R. Reeder,et al.  The REB1 site is an essential component of a terminator for RNA polymerase I in Saccharomyces cerevisiae , 1993, Molecular and cellular biology.

[87]  A. Sentenac,et al.  The TATA-binding protein participates in TFIIIB assembly on tRNA genes. , 1992, Nucleic acids research.

[88]  E. Geiduschek,et al.  The role of the TATA-binding protein in the assembly and function of the multisubunit yeast RNA polymerase III transcription factor, TFIIIB , 1992, Cell.

[89]  C. Pikaard,et al.  Cooperative binding of the Xenopus RNA polymerase I transcription factor xUBF to repetitive ribosomal gene enhancers , 1992, Molecular and cellular biology.

[90]  I. Grummt,et al.  Limited proteolysis unmasks specific DNA-binding of the murine RNA polymerase I-specific transcription termination factor TTFI. , 1992, Journal of molecular biology.

[91]  S. Hahn,et al.  A yeast TFIIB-related factor involved in RNA polymerase III transcription. , 1992, Genes & development.

[92]  I. Grummt,et al.  Dual role of the nucleolar transcription factor UBF: trans-activator and antirepressor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[93]  Q. Ju,et al.  Topoisomerases and yeast rRNA transcription: negative supercoiling stimulates initiation and topoisomerase activity is required for elongation. , 1992, Genes & development.

[94]  A. Schnapp,et al.  The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C‐terminal hyperacidic tail which is essential for transactivation. , 1992, The EMBO journal.

[95]  Steven Hahn,et al.  Variants of the TATA-binding protein can distinguish subsets of RNA polymerase I, II, and III promoters , 1992, Cell.

[96]  Kevin Struhl,et al.  The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells , 1992, Cell.

[97]  S. Smith,et al.  Analysis of the rat ribosomal DNA promoter: characterization of linker-scanning mutants and of the binding of UBF. , 1992, Nucleic acids research.

[98]  S. Smith,et al.  Analysis of the phosphorylation, DNA-binding and dimerization properties of the RNA polymerase I transcription factors UBF1 and UBF2. , 1992, Nucleic acids research.

[99]  R. Tjian,et al.  The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1 , 1992, Cell.

[100]  I. Pashev,et al.  Binding of histones to Xenopus laevis ribosomal genes with different levels of expression. , 1992, European journal of biochemistry.

[101]  S. Smith,et al.  Differential phosphorylation and localization of the transcription factor UBF in vivo in response to serum deprivation. In vitro dephosphorylation of UBF reduces its transactivation properties. , 1992, The Journal of biological chemistry.

[102]  Michel Werner,et al.  2 Yeast RNA Polymerase Subunits and Genes , 1992 .

[103]  M. Paule,et al.  The start site of the Acanthamoeba castellanii ribosomal RNA transcription unit. , 1992, Gene expression.

[104]  A. Schnapp,et al.  Transcription complex formation at the mouse rDNA promoter involves the stepwise association of four transcription factors and RNA polymerase I. , 1991, The Journal of biological chemistry.

[105]  B. McStay,et al.  xUBF contains a novel dimerization domain essential for RNA polymerase I transcription. , 1991, Genes & development.

[106]  M. Muramatsu,et al.  Cloning and structural analysis of cDNA and the gene for mouse transcription factor UBF. , 1991, Nucleic acids research.

[107]  D. Bachvarov,et al.  Heterogeneity in the Xenopus ribosomal transcription factor xUBF has a molecular basis distinct from that in mammals , 1991, FEBS letters.

[108]  D. Bachvarov,et al.  The RNA polymerase I transcription factor xUBF contains 5 tandemly repeated HMG homology boxes. , 1991, Nucleic acids research.

[109]  L. Rothblum,et al.  Identification of two forms of the RNA polymerase I transcription factor UBF. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[110]  P. Zahradka,et al.  Control points in eucaryotic ribosome biogenesis. , 1991, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[111]  S. Jacob,et al.  Purification and characterization of a novel factor which stimulates rat ribosomal gene transcription in vitro by interacting with enhancer and core promoter elements , 1990, Molecular and cellular biology.

[112]  E. A. Thompson,et al.  Hormonal regulation of transcription of rDNA. The role of TFIC in formation of initiation complexes. , 1990, The Journal of biological chemistry.

[113]  E. A. Thompson,et al.  Hormonal regulation of transcription of rDNA. Purification and characterization of the hormone-regulated transcription factor IC. , 1990, The Journal of biological chemistry.

[114]  A. Schnapp,et al.  A growth‐dependent transcription initiation factor (TIF‐IA) interacting with RNA polymerase I regulates mouse ribosomal RNA synthesis. , 1990, The EMBO journal.

[115]  C. Pikaard,et al.  Enhancers for RNA polymerase I in mouse ribosomal DNA , 1990, Molecular and cellular biology.

[116]  S. Smith,et al.  rUBF, an RNA polymerase I transcription factor from rats, produces DNase I footprints identical to those produced by xUBF, its homolog from frogs , 1990, Molecular and cellular biology.

[117]  R. Tjian,et al.  Assembly of alternative multiprotein complexes directs rRNA promoter selectivity. , 1990, Genes & development.

[118]  B. McStay,et al.  A DNA-binding protein is required for termination of transcription by RNA polymerase I in Xenopus laevis , 1990, Molecular and cellular biology.

[119]  S. Smith,et al.  Characterization of factors that direct transcription of rat ribosomal DNA , 1990, Molecular and cellular biology.

[120]  Robert Tjian,et al.  Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins , 1990, Nature.

[121]  S. Smith,et al.  Interaction of RNA polymerase I transcription factors with a promoter in the nontranscribed spacer of rat ribosomal DNA. , 1990, Nucleic acids research.

[122]  A. Schnapp,et al.  Isolation and functional characterization of TIF-IB, a factor that confers promoter specificity to mouse RNA polymerase I. , 1990, Nucleic acids research.

[123]  E. Nigg,et al.  cDNA sequences of chicken nucleolin/C23 and NO38/B23, two major nucleolar proteins. , 1990, Nucleic acids research.

[124]  J. Labbé,et al.  Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase , 1990, Cell.

[125]  P. Labhart,et al.  A point mutation uncouples RNA 3'-end formation and termination during ribosomal gene transcription in Xenopus laevis. , 1990, Genes & development.

[126]  J. Windle,et al.  Half helical turn spacing changes convert a frog into a mouse rDNA promoter: a distant upstream domain determines the helix face of the initiation site. , 1990, Genes & development.

[127]  R. Reeder.  rRNA synthesis in the nucleolus. , 1990, Trends in genetics : TIG.

[128]  R. Tjian,et al.  Molecular mechanisms governing species-specific transcription of ribosomal RNA , 1989, Cell.

[129]  S. Jacob,et al.  Glucocorticoid-induced stimulation of ribosomal gene transcription in rat hepatoma cells is mediated by modification of RNA polymerase I or an associated factor. , 1989, Molecular endocrinology.

[130]  H. Prats,et al.  Protein kinase NII and the regulation of rDNA transcription in mammalian cells. , 1989, Nucleic acids research.

[131]  Alexander Varshavsky,et al.  The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis , 1989, Nature.

[132]  R. Tjian,et al.  Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis. , 1988, Science.

[133]  H. Yang-Yen,et al.  Purification and characterization of a high-mobility-group-like DNA-binding protein that stimulates rRNA synthesis in vitro , 1988, Molecular and cellular biology.

[134]  K. Rose.  DNA topoisomerases as targets for chemotherapy , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[135]  E. Bateman,et al.  Events during eucaryotic rRNA transcription initiation and elongation: conversion from the closed to the open promoter complex requires nucleotide substrates , 1988, Molecular and cellular biology.

[136]  V. Culotta,et al.  Sites of topoisomerase I action on X. laevis ribosomal chromatin: Transcriptionally active rDNA has an ∼200 bp repeating structure , 1988, Cell.

[137]  J. Wang,et al.  Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[138]  F. Amalric,et al.  Phosphorylation of nucleolin by a nucleolar type NII protein kinase. , 1987, Biochemistry.

[139]  V. Culotta,et al.  Mouse and frog violate the paradigm of species-specific transcription of ribosomal RNA genes. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[140]  A. Sentenac,et al.  Active site labeling of the RNA polymerases A, B, and C from yeast. , 1987, The Journal of biological chemistry.

[141]  J. Tower,et al.  Transcription of mouse rDNA is regulated by an activated subform of RNA polymerase I , 1987, Cell.

[142]  E. Bateman,et al.  Eukaryotic RNA polymerase I promoter binding is directed by protein contacts with transcription initiation factor and is DNA sequence-independent , 1987, Cell.

[143]  L. Rothblum,et al.  Regions upstream from the core promoter of the rat ribosomal gene are required for the formation of a stable transcription initiation complex by RNA polymerase I in vitro. , 1987, Biochimica et biophysica acta.

[144]  B. Cullen,et al.  Mechanisms of control of gene expression , 1987 .

[145]  R. Sternglanz,et al.  Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA , 1987, Nature.

[146]  E. Bateman,et al.  Regulation of eukaryotic ribosomal RNA transcription by RNA polymerase modification , 1986, Cell.

[147]  H. Kato,et al.  Formation of the transcription initiation complex on mammalian rDNA , 1986, Molecular and cellular biology.

[148]  E. A. Thompson,et al.  Hormonal regulation of transcription of rDNA. Initiation of transcription by RNA polymerase I in vitro. , 1986, The Journal of biological chemistry.

[149]  I. Grummt,et al.  A purified transcription factor (TIF-IB) binds to essential sequences of the mouse rDNA promoter. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[150]  T. Moss,et al.  Spacer promoters are essential for efficient enhancement of X. laevis ribosomal transcription , 1986, Cell.

[151]  I. Grummt,et al.  Growth-dependent regulation of rRNA synthesis is mediated by a transcription initiation factor (TIF-IA). , 1985, Nucleic acids research.

[152]  R. Tjian,et al.  Purification and characterization of a transcription factor that confers promoter specificity to human RNA polymerase I , 1985, Molecular and cellular biology.

[153]  M. Muller,et al.  Eukaryotic type I topoisomerase is enriched in the nucleolus and catalytically active on ribosomal DNA. , 1985, The EMBO journal.

[154]  J. Tower,et al.  A complex control region of the mouse rRNA gene directs accurate initiation by RNA polymerase I , 1985, Molecular and cellular biology.

[155]  J. D'Alessio,et al.  In vitro evidence that eukaryotic ribosomal RNA transcription is regulated by modification of RNA polymerase I. , 1984, Nucleic acids research.

[156]  J. Wang,et al.  Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[157]  R. Reeder.  Enhancers and ribosomal gene spacers , 1984, Cell.

[158]  M. Paule.  Regulation of ribosomal RNA transcription during differentiation of Acanthamoeba castellanii: a review. , 1983, The Journal of protozoology.

[159]  R. Kominami,et al.  Fractiontion and reconstitution of factors required for accurate transcription of mammalian ribosomal RNA genes: identification of a species-depandent initiation factor , 1982 .

[160]  I. Grummt,et al.  Ribosomal RNA transcription in vitro is species specific , 1982, Nature.

[161]  P. Labhart,et al.  Structure of the active nucleolar chromatin of Xenopus laevis oocytes , 1982, Cell.

[162]  W. Rutter,et al.  Purification of rat liver and mouse ascites DNA-dependent RNA polymerase I. , 1977, Biochemistry.

[163]  R. Roeder,et al.  Purification and subunit structure of deoxyribonucleic acid-dependent ribonucleic acid polymerase III from the mouse plasmacytoma, MOPC 315. , 1975, The Journal of biological chemistry.