Imagining fictitious and future experiences: Evidence from developmental amnesia

Research highlights ▶ Jon is a patient with developmental amnesia and bilateral hippocampal damage. ▶ Despite this, he is able to richly imagine fictitious and future scenarios. ▶ This is in contrast to most patients with adult-acquired amnesia. ▶ Residual hippocampal function may underpin preserved simulation ability.

[1]  Demis Hassabis,et al.  Impaired spatial and non-spatial configural learning in patients with hippocampal pathology , 2007, Neuropsychologia.

[2]  Daniel L. Schacter,et al.  The case of K.C.: contributions of a memory-impaired person to memory theory , 2005, Neuropsychologia.

[3]  S. Petersen,et al.  Memory's echo: vivid remembering reactivates sensory-specific cortex. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[4]  D. Hassabis,et al.  Using Imagination to Understand the Neural Basis of Episodic Memory , 2007, The Journal of Neuroscience.

[5]  E. Maguire,et al.  The Human Hippocampus and Spatial and Episodic Memory , 2002, Neuron.

[6]  Demis Hassabis,et al.  Differential engagement of brain regions within a ‘core’ network during scene construction , 2010, Neuropsychologia.

[7]  M. Mishkin,et al.  The effects of bilateral hippocampal damage on fMRI regional activations and interactions during memory retrieval. , 2001, Brain : a journal of neurology.

[8]  Neil Burgess,et al.  Impaired memory for scenes but not faces in developmental hippocampal amnesia: A case study , 2008, Neuropsychologia.

[9]  E A Maguire,et al.  Neuroimaging studies of autobiographical event memory. , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[10]  D G Gadian,et al.  Hierarchical organization of cognitive memory. , 1997, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[11]  K. Szpunar.  Episodic Future Thought , 2010, Perspectives on psychological science : a journal of the Association for Psychological Science.

[12]  B. Levine,et al.  The functional neuroanatomy of autobiographical memory: A meta-analysis , 2006, Neuropsychologia.

[13]  Demis Hassabis,et al.  The construction system of the brain , 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

[14]  R. Nathan Spreng,et al.  The Common Neural Basis of Autobiographical Memory, Prospection, Navigation, Theory of Mind, and the Default Mode: A Quantitative Meta-analysis , 2009, Journal of Cognitive Neuroscience.

[15]  D. R. Addis,et al.  Deficits in past remembering extend to future imagining in a case of developmental amnesia , 2010, Neuropsychologia.

[16]  M. Mishkin,et al.  Human memory development and its dysfunction after early hippocampal injury , 2006, Trends in Neurosciences.

[17]  D. Hassabis,et al.  Deconstructing episodic memory with construction , 2007, Trends in Cognitive Sciences.

[18]  D. Schacter,et al.  Constructive episodic simulation of the future and the past: Distinct subsystems of a core brain network mediate imagining and remembering , 2009, Neuropsychologia.

[19]  K. Szpunar,et al.  Neural substrates of envisioning the future , 2007, Proceedings of the National Academy of Sciences.

[20]  D. Schacter,et al.  On the nature of medial temporal lobe contributions to the constructive simulation of future events , 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

[21]  G. Winocur,et al.  Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory , 2005, Journal of anatomy.

[22]  Eleanor A Maguire,et al.  The brain network associated with acquiring semantic knowledge , 2004, NeuroImage.

[23]  M. Mishkin,et al.  Dissociation between recognition and recall in developmental amnesia , 2009, Neuropsychologia.

[24]  P. McKenna,et al.  Preserved Semantic Learning in an Amnesic Patient , 2002, Cortex.

[25]  D. Hassabis,et al.  Patients with hippocampal amnesia cannot imagine new experiences , 2007, Proceedings of the National Academy of Sciences.

[26]  D. C. Howell,et al.  Comparing an Individual's Test Score Against Norms Derived from Small Samples , 1998 .

[27]  Karen R. Brandt,et al.  Impairment of recollection but not familiarity in a case of developmental amnesia , 2009, Neurocase.

[28]  Karen R. Brandt,et al.  Effects of level of processing but not of task enactment on recognition memory in a case of developmental amnesia , 2006, Cognitive neuropsychology.

[29]  L. Nadel,et al.  The Hippocampus as a Cognitive Map , 1978 .

[30]  J. Kihlstrom,et al.  THE EFFECTS OF EPISODIC MEMORY LOSS ON AN AMNESIC PATIENT ’ S ABILITY TO REMEMBER THE PAST AND IMAGINE THE FUTURE , 2003 .

[31]  J. Hodges.  Memory, Amnesia and the Hippocampal System , 1995 .

[32]  N. Burgess,et al.  The hippocampus and memory: insights from spatial processing , 2008, Nature Reviews Neuroscience.

[33]  E. Tulving,et al.  Episodic and semantic memory , 1972 .

[34]  E. Tulving,et al.  Organization of memory. , 1973 .

[35]  Andrew P. Yonelinas,et al.  Sparing of the familiarity component of recognition memory in a patient with hippocampal pathology , 2005, Neuropsychologia.

[36]  D. Schacter,et al.  Constructive episodic simulation: Temporal distance and detail of past and future events modulate hippocampal engagement , 2008, Hippocampus.

[37]  N. Burgess,et al.  The hippocampus is required for short‐term topographical memory in humans , 2007, Hippocampus.

[38]  P. Garthwaite,et al.  Investigation of the single case in neuropsychology: confidence limits on the abnormality of test scores and test score differences , 2002, Neuropsychologia.

[39]  R. Cabeza,et al.  Functional neuroimaging of autobiographical memory , 2007, Trends in Cognitive Sciences.

[40]  Demis Hassabis,et al.  Cortical midline involvement in autobiographical memory , 2009, NeuroImage.

[41]  Mortimer Mishkin,et al.  Preserved Recognition in a Case of Developmental Amnesia: Implications for the Acaquisition of Semantic Memory? , 2001, Journal of Cognitive Neuroscience.

[42]  M. Mishkin,et al.  Developmental amnesia associated with early hypoxic-ischaemic injury. , 2000, Brain : a journal of neurology.

[43]  Alana T. Wong,et al.  Remembering the past and imagining the future: Common and distinct neural substrates during event construction and elaboration , 2007, Neuropsychologia.

[44]  E. Denkova,et al.  Experiencing past and future personal events: Functional neuroimaging evidence on the neural bases of mental time travel , 2008, Brain and Cognition.

[45]  Masatoshi Itoh,et al.  Thinking of the future and past: the roles of the frontal pole and the medial temporal lobes , 2003, NeuroImage.

[46]  M. Mishkin,et al.  Differential effects of early hippocampal pathology on episodic and semantic memory. , 1997, Science.