Mosaicing of Fibered Fluorescence Microscopy Video

Fibered fluorescence microscopy is a recent developed image modality using a fiber optic probe connected to a laser scanning unit. It allows for in-vivo scanning of small animal subjects by moving the probe along the tissue surface. During the scans images are continuity captured, allowing to acquire an area larger then the field of view of the probe as a video. But there is still a need to obtain a single static image from the multiple overlapping frames. In this paper we introduce a mosaicing procedure for this kind of video sequence. An additional motivation for the mosaicing is the use of overlapping redundant information to improve the signal to noise level of the acquisition, since the individual frames tend to have both high noise levels and intensity inhomogeneities.