A Feedforward Loop within the Thyroid-Brown Fat Axis Facilitates Thermoregulation

[1]  B. Boehm,et al.  Brown Adipose Tissue: Multimodality Evaluation by PET, MRI, Infrared Thermography, and Whole‐Body Calorimetry (TACTICAL‐II) , 2019, Obesity.

[2]  Mihye Lee,et al.  Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs , 2019, Journal of clinical medicine.

[3]  Yan Lu,et al.  Elevated serum neuregulin 4 levels in patients with hyperthyroidism , 2019, Endocrine connections.

[4]  B. Bay,et al.  Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy , 2018, Autophagy.

[5]  Yen Ching Lim,et al.  De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesis , 2018, Nature Communications.

[6]  Q. Wan,et al.  Plasma Neuregulin 4 Levels Are Associated with Metabolic Syndrome in Patients Newly Diagnosed with Type 2 Diabetes Mellitus , 2018, Disease markers.

[7]  K. Krause,et al.  Thyroid hormones and browning of adipose tissue , 2017, Molecular and Cellular Endocrinology.

[8]  Jiandie D. Lin,et al.  The Micro-Managing Fat: Exosomes as a New Messenger , 2017, Trends in Endocrinology & Metabolism.

[9]  Jiandie D. Lin,et al.  Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders , 2017, Molecular metabolism.

[10]  A. Pfeifer,et al.  Brown Fat-Derived Exosomes: Small Vesicles with Big Impact. , 2017, Cell metabolism.

[11]  C. Henry,et al.  Gross and relative energy cost of domestic household activities in Asian men , 2016, European Journal of Clinical Nutrition.

[12]  Yanpeng Cao,et al.  A new method of infrared thermography for quantification of brown adipose tissue activation in healthy adults (TACTICAL): a randomized trial , 2016, The Journal of Physiological Sciences.

[13]  Yongjie Ma,et al.  Preventing High Fat Diet-induced Obesity and Improving Insulin Sensitivity through Neuregulin 4 Gene Transfer , 2016, Scientific Reports.

[14]  W. D. van Marken Lichtenbelt,et al.  Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity , 2016, Nature Communications.

[15]  J. Köhrle Selenium and the thyroid , 2015, Current opinion in endocrinology, diabetes, and obesity.

[16]  Jiandie D. Lin,et al.  The brown fat secretome: metabolic functions beyond thermogenesis , 2015, Trends in Endocrinology & Metabolism.

[17]  Zhimin Chen,et al.  The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuating hepatic lipogenesis , 2014, Nature Medicine.

[18]  G. Montana,et al.  Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice , 2014, American journal of physiology. Endocrinology and metabolism.

[19]  C. Diéguez,et al.  Energy balance regulation by thyroid hormones at central level. , 2013, Trends in molecular medicine.

[20]  P. Larsen,et al.  Role of the Iodothyronine Deiodinases in the Physiology and Pathophysiology of Thyroid Hormone Action , 2012, European Thyroid Journal.

[21]  T. Kawada,et al.  Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes. , 2012, American journal of physiology. Cell physiology.

[22]  Ricardo Lage,et al.  Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance , 2010, Nature Medicine.

[23]  Brian W Kim,et al.  Thyroid hormone as a determinant of energy expenditure and the basal metabolic rate. , 2008, Thyroid : official journal of the American Thyroid Association.

[24]  Y. Matsunaga,et al.  Enhanced Energy Expenditure and Fat Oxidation in Humans with High BMI Scores by the Ingestion of Novel and Non-Pungent Capsaicin Analogues (Capsinoids) , 2007, Bioscience, biotechnology, and biochemistry.

[25]  J. E. Silva,et al.  Thermogenic mechanisms and their hormonal regulation. , 2006, Physiological reviews.

[26]  L. Schomburg,et al.  Mutations in SECISBP2 result in abnormal thyroid hormone metabolism , 2005, Nature Genetics.

[27]  P. Laurberg,et al.  Cold Adaptation and Thyroid Hormone Metabolism , 2005, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[28]  J. Köhrle Selenium and the control of thyroid hormone metabolism. , 2005, Thyroid : official journal of the American Thyroid Association.

[29]  Paul Webb,et al.  Thyroxine-Thyroid Hormone Receptor Interactions* , 2004, Journal of Biological Chemistry.

[30]  B. Cannon,et al.  Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors. , 2004, Molecular endocrinology.

[31]  H. Vidal,et al.  Regulation of human adipocyte gene expression by thyroid hormone. , 2002, The Journal of clinical endocrinology and metabolism.

[32]  J. Harney,et al.  The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. , 2001, The Journal of clinical investigation.

[33]  J. E. Silva The multiple contributions of thyroid hormone to heat production. , 2001, The Journal of clinical investigation.

[34]  N. Negrão,et al.  Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat. , 2000, American journal of physiology. Endocrinology and metabolism.

[35]  L. Hoffer,et al.  Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement. , 1997, The Journal of clinical endocrinology and metabolism.

[36]  C. Reyes,et al.  Interactions among receptors, thyroid hormone response elements, and ligands in the regulation of the rat uncoupling protein gene expression by thyroid hormone. , 1996, Endocrinology.

[37]  J. E. Silva,et al.  Thyroid hormone control of thermogenesis and energy balance. , 1995, Thyroid : official journal of the American Thyroid Association.

[38]  J. E. Silva,et al.  Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene. , 1995, Endocrinology.

[39]  K. Ichihara,et al.  New indices for thyroid functional status, hormone binding, and peripheral hormone metabolism. Principal component analysis of 24,000 clinical data. , 1986, American journal of clinical pathology.

[40]  F. Sundler,et al.  Influence of the sympathetic nervous system on the secretion and metabolism of thyroid hormone. , 1977, Endocrinology.

[41]  J. B. Weir New methods for calculating metabolic rate with special reference to protein metabolism , 1949, The Journal of physiology.

[42]  A. Pfeifer,et al.  BAT Exosomes: Metabolic Crosstalk with Other Organs and Biomarkers for BAT Activity. , 2019, Handbook of experimental pharmacology.

[43]  D. Townsend,et al.  Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan. , 2018, The American journal of clinical nutrition.

[44]  G. Montana,et al.  Intrinsic differences in gene expression and response to 5 cold exposure in mice , 2014 .

[45]  G. Brent,et al.  Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis. , 2010, Endocrinology.

[46]  J. Wardle,et al.  A randomized trial , 2008 .