Modulation of protein stability by O-glycosylation in a designed Gc-MAF analog.

[1]  Sunney I Chan,et al.  Tuning the conformation properties of a peptide by glycosylation and phosphorylation. , 2006, Biochemical and biophysical research communications.

[2]  Jesús Jiménez-Barbero,et al.  New insights into alpha-GalNAc-Ser motif: influence of hydrogen bonding versus solvent interactions on the preferred conformation. , 2006, Journal of the American Chemical Society.

[3]  N. Swamy,et al.  Crystal structure of the complex between actin and human vitamin D-binding protein at 2.5 A resolution. , 2002, Biochemistry.

[4]  R. Aurora,et al.  Helix capping , 1998, Protein science : a publication of the Protein Society.

[5]  N. Yamamoto,et al.  Immunotherapy of BALB/c mice bearing Ehrlich ascites tumor with vitamin D-binding protein-derived macrophage activating factor. , 1997, Cancer research.

[6]  K. Toma,et al.  An NMR study of O-glycosylation induced structural changes in the alpha-helix of calcitonin. , 2002, Glycoconjugate journal.

[7]  A. Wand,et al.  De novo proteins as models of radical enzymes. , 1999, Biochemistry.

[8]  J. Kihlberg,et al.  A surface exposed O-linked galactose residue destabilises the structure of a folded helix-loop-helix dimer. , 2003, Organic & biomolecular chemistry.

[9]  Carolyn R. Bertozzi,et al.  Synthetic glycopeptides and glycoproteins as tools for biology. , 2005, Chemical Society reviews.

[10]  K. Toma,et al.  An NMR study of O-glycosylation induced structural changes in the α-helix of calcitonin , 2004, Glycoconjugate Journal.

[11]  W. L. Jorgensen,et al.  Comparison of simple potential functions for simulating liquid water , 1983 .

[12]  H. Kunz,et al.  Saccharide-induced peptide conformation in glycopeptides of the recognition region of LI-cadherin. , 2007, Angewandte Chemie.

[13]  G. Ghirlanda,et al.  A designed glycoprotein analogue of Gc-MAF exhibits native-like phagocytic activity. , 2006, Journal of the American Chemical Society.

[14]  B. Longenecker,et al.  Probing the conformational and dynamical effects of O-glycosylation within the immunodominant region of a MUC1 peptide tumor antigen. , 2008, The journal of peptide research : official journal of the American Peptide Society.

[15]  S. Hecht,et al.  Site-specific incorporation of glycosylated serine and tyrosine derivatives into proteins. , 2007, Journal of the American Chemical Society.

[16]  A. Andreotti,et al.  The effects of glycosylation on peptide backbone conformation , 1993 .

[17]  J. Bertolini,et al.  Therapeutic potential of vitamin D-binding protein. , 2004, Trends in biotechnology.

[18]  W. DeGrado,et al.  Solution structure and dynamics of a de novo designed three-helix bundle protein. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[19]  T. Darden,et al.  A smooth particle mesh Ewald method , 1995 .

[20]  R. Cole,et al.  O-Linked N-Acetylglucosamine: The “Yin-Yang” of Ser/Thr Phosphorylation? , 1995 .

[21]  R. D'Amato,et al.  Vitamin D binding protein-macrophage activating factor (DBP-maf) inhibits angiogenesis and tumor growth in mice. , 2003, Neoplasia.

[22]  D. W. Bolen,et al.  Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants. , 1988, Biochemistry.

[23]  S. Nosé.  A molecular dynamics method for simulations in the canonical ensemble , 1984 .

[24]  Alexander D. MacKerell,et al.  Extending the treatment of backbone energetics in protein force fields: Limitations of gas‐phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations , 2004, J. Comput. Chem..

[25]  R. J. Solá,et al.  Modulation of protein biophysical properties by chemical glycosylation: biochemical insights and biomedical implications , 2007, Cellular and Molecular Life Sciences.

[26]  Y. Fujibayashi,et al.  Site-dependent effect of O-glycosylation on the conformation and biological activity of calcitonin. , 2001, Biochemistry.

[27]  G. Hart,et al.  O-Glycosylation of Nuclear and Cytosolic Proteins , 2000, The Journal of Biological Chemistry.

[28]  J. Kihlberg,et al.  The effect of glycosylation on the structure of designed four-helix bundle motifs , 2000 .

[29]  P. Argos,et al.  Knowledge‐based protein secondary structure assignment , 1995, Proteins.

[30]  G. Ciccotti,et al.  Numerical Integration of the Cartesian Equations of Motion of a System with Constraints: Molecular Dynamics of n-Alkanes , 1977 .

[31]  S. Asbell,et al.  Deglycosylation of serum vitamin D3-binding protein leads to immunosuppression in cancer patients. , 1996, Cancer research.

[32]  R. Bouillon,et al.  A structural basis for the unique binding features of the human vitamin D-binding protein , 2002, Nature Structural Biology.

[33]  Hoover,et al.  Canonical dynamics: Equilibrium phase-space distributions. , 1985, Physical review. A, General physics.

[34]  Christian Bartels,et al.  Multidimensional adaptive umbrella sampling: Applications to main chain and side chain peptide conformations , 1997, J. Comput. Chem..

[35]  Alexander D. MacKerell,et al.  All-atom empirical potential for molecular modeling and dynamics studies of proteins. , 1998, The journal of physical chemistry. B.

[36]  A. R. Fresht.  Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding , 1999 .

[37]  M. Karplus,et al.  CHARMM: A program for macromolecular energy, minimization, and dynamics calculations , 1983 .

[38]  D. W. Bolen,et al.  Unfolding free energy changes determined by the linear extrapolation method. 2. Incorporation of delta G degrees N-U values in a thermodynamic cycle. , 1988, Biochemistry.

[39]  Alexander D. MacKerell,et al.  Computational Biochemistry and Biophysics , 2001 .

[40]  Kevin J. Naidoo,et al.  Carbohydrate solution simulations: Producing a force field with experimentally consistent primary alcohol rotational frequencies and populations , 2002, J. Comput. Chem..

[41]  A. Wand,et al.  Structure of a de novo designed protein model of radical enzymes. , 2002, Journal of the American Chemical Society.

[42]  R. Kumashiro,et al.  Conversion of vitamin D3 binding protein (group-specific component) to a macrophage activating factor by the stepwise action of beta-galactosidase of B cells and sialidase of T cells. , 1993, Journal of immunology.

[43]  Carolyn R. Bertozzi,et al.  Essentials of Glycobiology , 1999 .