Advances in transdermal insulin delivery.

[1]  Samir Mitragotri,et al.  Sonophoresis: a 50-year journey. , 2004, Drug discovery today.

[2]  Guohua Jiang,et al.  Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin. , 2017, Materials science & engineering. C, Materials for biological applications.

[3]  Benjamin C. Tang,et al.  Managing diabetes with nanomedicine: challenges and opportunities , 2014, Nature Reviews Drug Discovery.

[4]  David R. Owens,et al.  New horizons — alternative routes for insulin therapy , 2002, Nature Reviews Drug Discovery.

[5]  Jin-Lan Zhang,et al.  Transdermal delivery of insulin using microneedle rollers in vivo. , 2010, International journal of pharmaceutics.

[6]  Seung Hun Lee,et al.  The Pretreatment Effect of Chemical Skin Penetration Enhancers in Transdermal Drug Delivery Using Iontophoresis , 1999, Skin Pharmacology and Physiology.

[7]  William J. Welsh,et al.  Phase‐Transition Microneedle Patches for Efficient and Accurate Transdermal Delivery of Insulin , 2015 .

[8]  Q. Ping,et al.  Transdermal delivery of insulin in mice by using lecithin vesicles as a carrier. , 2000, Drug delivery.

[9]  X. Jing,et al.  H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery. , 2017, ACS nano.

[10]  Zhenguo Liu,et al.  Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine , 2013, Drug design, development and therapy.

[11]  Zhen Gu,et al.  Ultrasound‐Triggered Regulation of Blood Glucose Levels Using Injectable Nano‐Network , 2014, Advanced healthcare materials.

[12]  D. Kohane,et al.  Getting Drugs Across Biological Barriers , 2017, Advanced materials.

[13]  M. Goto,et al.  A solid-in-oil dispersion of gold nanorods can enhance transdermal protein delivery and skin vaccination. , 2011, Small.

[14]  John Pickup,et al.  Continuous subcutaneous insulin infusion at 25 years: evidence base for the expanding use of insulin pump therapy in type 1 diabetes. , 2002, Diabetes care.

[15]  Meng-Tsan Tsai,et al.  Formulation of two-layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice. , 2017, Journal of biomedical materials research. Part A.

[16]  Praveen Kumar,et al.  Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats. , 2002, Diabetes technology & therapeutics.

[17]  J. Weaver,et al.  Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[18]  Aarti Naik,et al.  Iontophoretic drug delivery. , 2004, Advanced drug delivery reviews.

[19]  Serge Rudaz,et al.  Extraction of amino acids by reverse iontophoresis in vivo. , 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[20]  Samir Mitragotri,et al.  Immunization without needles , 2005, Nature Reviews Immunology.

[21]  S. Giannos.  Skin microporation: strategies to enhance and expand transdermal drug delivery , 2014 .

[22]  M. Prausnitz,et al.  Transdermal Insulin Delivery Using Microdermabrasion , 2011, Pharmaceutical Research.

[23]  S. Jacobsen,et al.  Potential novel methods for insulin administration: I. Iontophoresis. , 1984, Biomedica biochimica acta.

[24]  Lokesh Shahani,et al.  Use of insulin in diabetes: a century of treatment. , 2015, Hong Kong medical journal = Xianggang yi xue za zhi.

[25]  S. Mitragotri,et al.  Needle-free liquid jet injections: mechanisms and applications , 2006, Expert review of medical devices.

[26]  Ryan F. Donnelly,et al.  Microneedles: A New Frontier in Nanomedicine Delivery , 2016, Pharmaceutical Research.

[27]  M. Prausnitz,et al.  Long-term stability of influenza vaccine in a dissolving microneedle patch , 2016, Drug Delivery and Translational Research.

[28]  L. Fraiwan,et al.  Noninvasive Transdermal Insulin Delivery Using Piston-Shaped PZT Transducers : In vivo Rabbits Evaluation , 2012 .

[29]  Min-Hsien Wu,et al.  Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for in vivo insulin transdermal delivery , 2017 .

[30]  Matthew Page,et al.  Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus. , 2010, The Cochrane database of systematic reviews.

[31]  Zhen Gu,et al.  Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment. , 2017, ACS nano.

[32]  N. Smith,et al.  Closed‐loop controlled noninvasive ultrasonic glucose sensing and insulin delivery , 2010 .

[33]  B. Zinman,et al.  Alternative routes of insulin delivery , 2003, Diabetic medicine : a journal of the British Diabetic Association.

[34]  N. Byl,et al.  The use of ultrasound as an enhancer for transcutaneous drug delivery: phonophoresis. , 1995, Physical therapy.

[35]  Vesna Zderic,et al.  Ultrasound Stimulation of Insulin Release from Pancreatic Beta Cells as a Potential Novel Treatment for Type 2 Diabetes. , 2017, Ultrasound in medicine & biology.

[36]  M. Goto,et al.  Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice. , 2012, Nanoscale.

[37]  Wijaya Martanto,et al.  Transdermal Delivery of Insulin Using Microneedles in Vivo , 2004, Pharmaceutical Research.

[38]  Mei-Chin Chen,et al.  Poly-γ-glutamic acid microneedles with a supporting structure design as a potential tool for transdermal delivery of insulin. , 2015, Acta biomaterialia.

[39]  Jung-Hwan Park,et al.  Microneedles for drug and vaccine delivery. , 2012, Advanced drug delivery reviews.

[40]  M. Atkinson,et al.  Type 1 diabetes: new perspectives on disease pathogenesis and treatment , 2001, The Lancet.

[41]  H. Kalluri,et al.  Microchannels created by sugar and metal microneedles: characterization by microscopy, macromolecular flux and other techniques. , 2010, Journal of pharmaceutical sciences.

[42]  Honggang Zhu,et al.  Effects of electrophoresis and electroosmosis during alternating current iontophoresis across human epidermal membrane. , 2005, Journal of pharmaceutical sciences.

[43]  K. Sugibayashi,et al.  Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[44]  M. Allen,et al.  Microfabricated microneedles: a novel approach to transdermal drug delivery. , 1998, Journal of pharmaceutical sciences.

[45]  Mark R. Prausnitz,et al.  Intradermal Vaccination with Influenza Virus-Like Particles by Using Microneedles Induces Protection Superior to That with Intramuscular Immunization , 2010, Journal of Virology.

[46]  C. Coussios,et al.  Cavitation-enhanced delivery of insulin in agar and porcine models of human skin. , 2015, Physics in medicine and biology.

[47]  Rui Tian,et al.  Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy , 2017, Nature Communications.

[48]  O. Pillai,et al.  Transdermal iontophoresis of insulin: IV. Influence of chemical enhancers. , 2004, International journal of pharmaceutics.

[49]  M. Goto,et al.  Transdermal delivery of insulin using a solid-in-oil nanodispersion enhanced by arginine-rich peptides , 2012 .

[50]  Mark R Prausnitz,et al.  Dissolving microneedle patch for transdermal delivery of human growth hormone. , 2011, Small.

[51]  L. Ananthanarayan,et al.  Glucose oxidase--an overview. , 2009, Biotechnology advances.

[52]  Mark G. Allen,et al.  Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[53]  Göran Stemme,et al.  Painless Drug Delivery Through Microneedle-Based Transdermal Patches Featuring Active Infusion , 2008, IEEE Transactions on Biomedical Engineering.

[54]  Zhen Gu,et al.  Stimuli‐responsive delivery of therapeutics for diabetes treatment , 2016, Bioengineering & translational medicine.

[55]  M. Foldvari,et al.  Evidence for lymphatic transport of insulin by topically applied biphasic vesicles , 2003, The Journal of pharmacy and pharmacology.

[56]  Qifu Li,et al.  Lispro administered by the QS-M Needle-Free Jet Injector generates an earlier insulin exposure , 2016, Expert opinion on drug delivery.

[57]  E. Araki,et al.  Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. , 1995, Diabetes research and clinical practice.

[58]  Zhen Gu,et al.  Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots. , 2015, ACS nano.

[59]  J. Weissberg-Benchell,et al.  Insulin pump therapy: a meta-analysis. , 2003, Diabetes care.

[60]  M. Fujishima,et al.  Regurgitation of blood into insulin cartridges in the pen-like injectors. , 2001, Diabetes care.

[61]  C. Tack,et al.  Insulin administered by needle‐free jet injection corrects marked hyperglycaemia faster in overweight or obese patients with diabetes , 2015, Diabetes, obesity & metabolism.

[62]  R. Narayan.  Transdermal delivery of insulin via microneedles. , 2014, Journal of biomedical nanotechnology.

[63]  H. Katsumi,et al.  Transdermal delivery of insulin using trypsin as a biochemical enhancer. , 2008, Biological & pharmaceutical bulletin.

[64]  James D. Campbell,et al.  Needle-free vaccine delivery. , 2006, Advanced drug delivery reviews.

[65]  Mark R Prausnitz,et al.  Microneedles for transdermal drug delivery. , 2004, Advanced drug delivery reviews.

[66]  Myunggi An,et al.  Dissolving Microneedle Arrays for Transdermal Delivery of Amphiphilic Vaccines. , 2017, Small.

[67]  Ciprian Iliescu,et al.  In Vivo Experimental Study of Noninvasive Insulin Microinjection through Hollow Si Microneedle Array , 2018, Micromachines.

[68]  S. MacNeil,et al.  Transdermal drug delivery: from micro to nano. , 2012, Nanoscale.

[69]  Y. Yamaguchi,et al.  Transdermal delivery of CaCO3-nanoparticles containing insulin. , 2006, Diabetes technology & therapeutics.

[70]  Zhen Gu,et al.  Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody. , 2016, Nano letters.

[71]  M. Roberts,et al.  Topical Nano and Microemulsions for Skin Delivery , 2017, Pharmaceutics.

[72]  S. Jacobsen,et al.  Potential novel methods for insulin administration: II. Self-regulating internal drug delivery systems. , 1984, Biomedica biochimica acta.

[73]  Nadine Barrie Smith,et al.  Ultrasound-mediated transdermal in vivo transport of insulin with low-profile cymbal arrays. , 2003, Ultrasound in medicine & biology.

[74]  Regina Luttge,et al.  Silicon micromachined hollow microneedles for transdermal liquid transport , 2003 .

[75]  Zhen Gu,et al.  ROS-Responsive Microneedle Patch for Acne Vulgaris Treatment (Adv. Therap. 3/2018) , 2018, Advanced Therapeutics.

[76]  J. Weaver,et al.  Analysis of enhanced transdermal transport by skin electroporation , 1995 .

[77]  P. Ramarao,et al.  Transdermal iontophoretic delivery of bovine insulin and monomeric human insulin analogue. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[78]  Meng-Tsan Tsai,et al.  Fabrication of a novel partially dissolving polymer microneedle patch for transdermal drug delivery. , 2015, Journal of materials chemistry. B.

[79]  Jeffrey M Karp,et al.  A self‐adherent, bullet‐shaped microneedle patch for controlled transdermal delivery of insulin , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[80]  Samir Mitragotri,et al.  Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets , 2007, Proceedings of the National Academy of Sciences.

[81]  Roman Hovorka,et al.  Closed-loop insulin delivery: from bench to clinical practice , 2011, Nature Reviews Endocrinology.

[82]  Guohua Jiang,et al.  Transdermal delivery of insulin with bioceramic composite microneedles fabricated by gelatin and hydroxyapatite. , 2017, Materials science & engineering. C, Materials for biological applications.

[83]  J. Danesh,et al.  Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. , 2010, Lancet.

[84]  Zhen Gu,et al.  Bioresponsive transcutaneous patches. , 2017, Current opinion in biotechnology.

[85]  Zhen Gu,et al.  Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery , 2015, Proceedings of the National Academy of Sciences.

[86]  A. Banga,et al.  In vitro transdermal delivery of therapeutic antibodies using maltose microneedles. , 2009, International journal of pharmaceutics.

[87]  Shih-Fang Huang,et al.  Fully embeddable chitosan microneedles as a sustained release depot for intradermal vaccination. , 2013, Biomaterials.

[88]  T M Morgan,et al.  Transdermal penetration enhancers: applications, limitations, and potential. , 1999, Journal of pharmaceutical sciences.

[89]  Michael J. Pikal,et al.  The role of electroosmotic flow in transdermal iontophoresis , 1992 .

[90]  Guohua Jiang,et al.  Microneedles Integrated with ZnO Quantum-Dot-Capped Mesoporous Bioactive Glasses for Glucose-Mediated Insulin Delivery. , 2018, ACS biomaterials science & engineering.

[91]  Adrian C. Williams,et al.  Penetration enhancers. , 2004, Advanced drug delivery reviews.

[92]  S. Madihally,et al.  Effect of different enhancers on the transdermal permeation of insulin analog. , 2010, International journal of pharmaceutics.

[93]  Jaimini Cegla,et al.  Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery , 2015, Annals of clinical biochemistry.

[94]  F. Patat,et al.  Effect of sonication parameters on transdermal delivery of insulin to hairless rats. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[95]  I. Raz,et al.  Improved Insulin Pharmacokinetics Using a Novel Microneedle Device for Intradermal Delivery in Patients with Type 2 Diabetes , 2016, Diabetes technology & therapeutics.

[96]  C. Tack,et al.  Needle-Free Jet Injection of Rapid-Acting Insulin Improves Early Postprandial Glucose Control in Patients With Diabetes , 2013, Diabetes Care.

[97]  Mark G. Allen,et al.  Polymer Microneedles for Controlled-Release Drug Delivery , 2006, Pharmaceutical Research.

[98]  N. Smith,et al.  Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection , 2008, International journal of nanomedicine.

[99]  Rajesh Vadlapatla,et al.  Electronic drug delivery systems: An overview , 2017 .

[100]  S. Raptis,et al.  Efficacy of a new needleless insulin delivery system monitoring of blood glucose fluctuations and free insulin levels. , 1989, The International journal of artificial organs.

[101]  M. Goto,et al.  A solid-in-oil nanodispersion for transcutaneous protein delivery. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[102]  Jayakumar Rajadas,et al.  Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications. , 2013, Acta biomaterialia.

[103]  Xinhua Xiao,et al.  Comparison of jet injector and insulin pen in controlling plasma glucose and insulin concentrations in type 2 diabetic patients , 2017, Medicine.

[104]  Bogdan Catargi,et al.  Chemically controlled closed-loop insulin delivery. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[105]  B. Godin,et al.  Vesicular Carriers for Enhanced delivery through the skin , 2006 .

[106]  M. Daly,et al.  Transdermal insulin delivery using lipid enhanced electroporation. , 2002, Biochimica et biophysica acta.

[107]  S. Hui,et al.  Painless skin electroporation as a novel way for insulin delivery. , 2011, Diabetes technology & therapeutics.

[108]  A. Riga,et al.  AC electrokinetic platform for iontophoretic transdermal drug delivery. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[109]  W. Shi,et al.  Transdermal Iontophoretic Delivery of Therapeutic Peptides/Proteins I: Insulin , 1987, Annals of the New York Academy of Sciences.

[110]  Nadine Barrie Smith,et al.  Ultrasound-mediated transdermal transport of insulin in vitro through human skin using novel transducer designs. , 2003, Ultrasound in medicine & biology.

[111]  Wen-Cheng Yang,et al.  Multidrug release based on microneedle arrays filled with pH-responsive PLGA hollow microspheres. , 2012, Biomaterials.

[112]  Wenjuan Yang,et al.  Transdermal protein delivery by a coadministered peptide identified via phage display , 2006, Nature Biotechnology.

[113]  S. Greene,et al.  Adherence to insulin treatment, glycaemic control, and ketoacidosis in insulin-dependent diabetes mellitus , 1997, The Lancet.

[114]  F. Ligler,et al.  Leveraging H2O2 Levels for Biomedical Applications , 2017, Advanced biosystems.

[115]  R. Guy,et al.  Iontophoresis of monomeric insulin analogues in vitro: effects of insulin charge and skin pretreatment. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[116]  Y. Anissimov,et al.  Microneedles as the technique of drug delivery enhancement in diverse organs and tissues. , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[117]  Yukako Ito,et al.  Transdermal insulin application system with dissolving microneedles. , 2012, Diabetes technology & therapeutics.

[118]  Mark R Prausnitz,et al.  Engineering Microneedle Patches for Vaccination and Drug Delivery to Skin. , 2017, Annual review of chemical and biomolecular engineering.

[119]  C. Zakzewski,et al.  Transdermal delivery of regular insulin to chronic diabetic rats: effect of skin preparation and electrical enhancement. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[120]  Zhen Gu,et al.  ROS‐Responsive Microneedle Patch for Acne Vulgaris Treatment , 2018 .

[121]  Yoshinori Onuki,et al.  Current challenges in non-invasive insulin delivery systems: a comparative review. , 2007, Advanced drug delivery reviews.

[122]  P. Tyle,et al.  Drug Delivery by Phonophoresis , 1989, Pharmaceutical Research.

[123]  Suyong Kim,et al.  Rapid implantation of dissolving microneedles on an electrospun pillar array. , 2015, Biomaterials.

[124]  Dan Dan Zhu,et al.  Insulin delivery systems combined with microneedle technology. , 2018, Advanced drug delivery reviews.

[125]  Samir Mitragotri,et al.  Transdermal Drug Delivery Using Low-Frequency Sonophoresis , 2004, Pharmaceutical Research.

[126]  J. Bos,et al.  The 500 Dalton rule for the skin penetration of chemical compounds and drugs , 2000, Experimental dermatology.

[127]  External control of drug release: controlled release of insulin from a hydrophilic polymer implant by ultrasound irradiation in diabetic rats , 1988, The Journal of pharmacy and pharmacology.

[128]  M. Goto,et al.  Transcutaneous immunization by a solid-in-oil nanodispersion. , 2010, Chemical communications.

[129]  Mark R Prausnitz,et al.  Faster pharmacokinetics and increased patient acceptance of intradermal insulin delivery using a single hollow microneedle in children and adolescents with type 1 diabetes , 2013, Pediatric diabetes.

[130]  Guohua Jiang,et al.  Fabrication of biodegradable composite microneedles based on calcium sulfate and gelatin for transdermal delivery of insulin. , 2017, Materials science & engineering. C, Materials for biological applications.

[131]  A. Sintov,et al.  Topical iodine facilitates transdermal delivery of insulin. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[132]  Tielin Shi,et al.  Iontophoresis-driven penetration of nanovesicles through microneedle-induced skin microchannels for enhancing transdermal delivery of insulin. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[133]  S. Hui,et al.  Lipid and electroosmosis enhanced transdermal delivery of insulin by electroporation. , 2006, Journal of pharmaceutical sciences.

[134]  Zhen Gu,et al.  Polymeric microneedles for transdermal protein delivery☆ , 2018, Advanced drug delivery reviews.

[135]  Guangjiong Qin,et al.  Sustained release of insulin through skin by intradermal microdelivery system , 2010, Biomedical microdevices.

[136]  B. Zinman,et al.  Insulins today and beyond , 2001, The Lancet.

[137]  R. Newnham,et al.  Noninvasive ultrasonic transdermal insulin delivery in rabbits using the light-weight cymbal array. , 2003, Diabetes technology & therapeutics.

[138]  R. Newnham,et al.  Short ultrasound exposure times for noninvasive insulin delivery in rats using the lightweight cymbal array , 2004, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[139]  Y. Chien,et al.  Facilitated transdermal transport of insulin. , 1987, Journal of pharmaceutical sciences.

[140]  Zhen Gu,et al.  Leveraging Physiology for Precision Drug Delivery , 2017 .

[141]  W. Elshemey,et al.  Electroporation Parameters for Successful Transdermal Delivery of Insulin , 2015, American journal of therapeutics.

[142]  K. Kanamura,et al.  Noninvasive and persistent transfollicular drug delivery system using a combination of liposomes and iontophoresis. , 2011, International journal of pharmaceutics.

[143]  J. Mayer,et al.  Pursuit of a perfect insulin , 2016, Nature Reviews Drug Discovery.

[144]  Guohua Jiang,et al.  Fabrication of composite microneedles integrated with insulin-loaded CaCO3 microparticles and PVP for transdermal delivery in diabetic rats. , 2018, Materials science & engineering. C, Materials for biological applications.

[145]  Véronique Préat,et al.  Skin electroporation for transdermal and topical delivery. , 2004, Advanced drug delivery reviews.

[146]  F. Pass,et al.  Delivery of insulin by jet injection: recent observations. , 2001, Diabetes technology & therapeutics.

[147]  Nissim Garti,et al.  Microemulsions as transdermal drug delivery vehicles. , 2006, Advances in colloid and interface science.

[148]  N. Grove,et al.  Comparison of Insulin Levels After Injection by Jet Stream and Disposable Insulin Syringe , 1986, Diabetes Care.

[149]  Cees W J Oomens,et al.  Penetration and delivery characteristics of repetitive microjet injection into the skin. , 2016, Journal of controlled release : official journal of the Controlled Release Society.

[150]  Haripriya Kalluri,et al.  Formation and Closure of Microchannels in Skin Following Microporation , 2010, Pharmaceutical Research.

[151]  C. Tack,et al.  Improved Pharmacokinetic and Pharmacodynamic Profile of Rapid-Acting Insulin Using Needle-Free Jet Injection Technology , 2011, Diabetes Care.

[152]  Robert Langer,et al.  Transdermal drug delivery , 2008, Nature Biotechnology.

[153]  José Juan Escobar-Chávez,et al.  Electroporation as an Efficient Physical Enhancer for Skin Drug Delivery , 2009, Journal of clinical pharmacology.

[154]  Lutz Heinemann,et al.  Microneedle-based intradermal versus subcutaneous administration of regular human insulin or insulin lispro: pharmacokinetics and postprandial glycemic excursions in patients with type 1 diabetes. , 2011, Diabetes technology & therapeutics.

[155]  Guohua Jiang,et al.  H2O2-Responsive mesoporous silica nanoparticles integrated with microneedle patches for the glucose-monitored transdermal delivery of insulin. , 2017, Journal of materials chemistry. B.

[156]  Hai-Dong Liang,et al.  Medical ultrasound: imaging of soft tissue strain and elasticity , 2011, Journal of The Royal Society Interface.

[157]  Diti Chatterjee Bhowmick,et al.  Calcium-dependent ultrasound stimulation of secretory events from pancreatic beta cells , 2017, Journal of therapeutic ultrasound.

[158]  Zhen Gu,et al.  Mechanical Force-Triggered Drug Delivery. , 2016, Chemical reviews.

[159]  R. Birnbacher,et al.  Painfulness of needle and jet injection in children with diabetes mellitus , 1994, European Journal of Pediatrics.

[160]  Jagdish Singh,et al.  Transepidermal Transport Enhancement of Insulin by Lipid Extraction and Iontophoresis , 2002, Pharmaceutical Research.

[161]  Seajin Oh,et al.  Dissolvable microneedle patches for the delivery of cell-culture-derived influenza vaccine antigens. , 2012, Journal of pharmaceutical sciences.

[162]  Mei-Chin Chen,et al.  Chitosan microneedle patches for sustained transdermal delivery of macromolecules. , 2012, Biomacromolecules.

[163]  Guojun Ma,et al.  Microneedle, bio‐microneedle and bio‐inspired microneedle: A review , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[164]  S. Mitragotri,et al.  Current status and future potential of transdermal drug delivery , 2004, Nature Reviews Drug Discovery.

[165]  Ronald A. Roy,et al.  Applications of Acoustics and Cavitation to Noninvasive Therapy and Drug Delivery , 2008 .

[166]  E. Fabrizio,et al.  Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol , 2006 .

[167]  Nadine Barrie Smith,et al.  Ultrasound Mediated Transdermal Insulin Delivery in Pigs Using a Lightweight Transducer , 2007, Pharmaceutical Research.

[168]  Lei Zhang,et al.  Enhanced transdermal transport by electroporation using anionic lipids. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[169]  K. Sugibayashi,et al.  Effect of electroporation and pH on the iontophoretic transdermal delivery of human insulin. , 2006, International journal of pharmaceutics.

[170]  Yie W. Chien,et al.  Iontophoretic delivery of drugs: Fundamentals, developments and biomedical applications , 1988 .

[171]  Mei-Chin Chen,et al.  Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats. , 2013, Acta biomaterialia.

[172]  F. Patat,et al.  A practical use of low frequency ultrasound for rapid and reproducible transdermal delivery of insulin , 2001, 2001 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.01CH37263).

[173]  Akira Yamamoto,et al.  The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[174]  Hyungil Jung,et al.  Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose. , 2011, Biomaterials.

[175]  R. Heine,et al.  The Medi‐Jector II: Efficacy and Acceptability in Insulin‐dependent Diabetic Patients With and Without Needle Phobia , 1988, Diabetic medicine : a journal of the British Diabetic Association.

[176]  The Emerging Risk Factors Collaboration.  Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies , 2010, The Lancet.

[177]  Michael S Strano,et al.  Glucose-responsive insulin by molecular and physical design , 2017, Nature Chemistry.

[178]  Nadine Barrie Smith,et al.  Ultrasound mediated transdermal in vivo transport of insulin with low profile cymbal arrays , 2002, 2002 IEEE Ultrasonics Symposium, 2002. Proceedings..

[179]  Quanyin Hu,et al.  Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors. , 2016, ACS nano.

[180]  Michael Stumvoll,et al.  Type 2 diabetes: principles of pathogenesis and therapy , 2005, The Lancet.

[181]  S. Mitragotri,et al.  Low-frequency sonophoresis: a review. , 2004, Advanced drug delivery reviews.

[182]  Zhen Gu,et al.  A melanin-mediated cancer immunotherapy patch , 2017, Science Immunology.

[183]  Zhen Gu,et al.  Hypoxia-Sensitive Materials for Biomedical Applications , 2016, Annals of Biomedical Engineering.

[184]  Zhen Gu,et al.  Glucose-Responsive Microneedle Patches for Diabetes Treatment , 2018, Journal of diabetes science and technology.

[185]  F. Tse,et al.  Effect of Current Magnitude and Drug Concentration on lontophoretic Delivery of Octreotide Acetate (Sandostatin®) in the Rabbit , 1994, Pharmaceutical Research.

[186]  Biana Godin,et al.  Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models. , 2007, Advanced drug delivery reviews.

[187]  A. Banga,et al.  Characterization of in Vitro Transdermal Iontophoretic Delivery of Insulin , 1993 .

[188]  D. Markley,et al.  Composite Transducer Arrays for the Treatment of Diabetes , 2005 .

[189]  V. Koul,et al.  Electroporation of polymeric nanoparticles: an alternative technique for transdermal delivery of insulin , 2010, Drug development and industrial pharmacy.

[190]  Kang-Ming Chang,et al.  A circuit design of a low-cost, portable and programmable electroporation device for biomedical applications , 2012 .

[191]  Samir Mitragotri,et al.  Design principles of chemical penetration enhancers for transdermal drug delivery. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[192]  Ichiro Katayama,et al.  Clinical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch. , 2015, Biomaterials.

[193]  J. Bouwstra,et al.  Dissolving Microneedle Patches for Dermal Vaccination , 2017, Pharmaceutical Research.

[194]  Yuming Sun,et al.  Effect of cationic cyclopeptides on transdermal and transmembrane delivery of insulin. , 2013, Molecular pharmaceutics.

[195]  Mark Borden,et al.  Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery. , 2007, Annual review of biomedical engineering.

[196]  Zhen Gu,et al.  Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules , 2017, Nano Research.

[197]  Robert Langer,et al.  Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[198]  Joseph Kost,et al.  Ultrasound mediated transdermal drug delivery. , 2014, Advanced drug delivery reviews.

[199]  Göran Stemme,et al.  Novel Microneedle Patches for Active Insulin Delivery are Efficient in Maintaining Glycaemic Control: An Initial Comparison with Subcutaneous Administration , 2007, Pharmaceutical Research.

[200]  S. Murdan.  Electro-responsive drug delivery from hydrogels. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[201]  C. Weller,et al.  Jet injection of insulin vs the syringe-and-needle method. , 1966, JAMA.

[202]  H. Iyer,et al.  Oral insulin – a review of current status , 2010, Diabetes, obesity & metabolism.

[203]  Jung-Hwan Park,et al.  Dissolving microneedles for transdermal drug delivery. , 2008, Biomaterials.

[204]  Adam J. Davidson,et al.  Transdermal drug delivery by coated microneedles: geometry effects on drug concentration in blood , 2009 .

[205]  Yong Zhu,et al.  Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery. , 2017, Nano letters.

[206]  S. Kagatani,et al.  Electroresponsive pulsatile depot delivery of insulin from poly(dimethylaminopropylacrylamide) gel in rats. , 1997, Journal of pharmaceutical sciences.

[207]  Stefano C. Meliga,et al.  Formulations for microprojection/microneedle vaccine delivery: Structure, strength and release profiles. , 2016, Journal of controlled release : official journal of the Controlled Release Society.

[208]  O. Pillai,et al.  Transdermal delivery of insulin from poloxamer gel: ex vivo and in vivo skin permeation studies in rat using iontophoresis and chemical enhancers. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[209]  Zhen Gu,et al.  Bioresponsive Microneedles with a Sheath Structure for H2 O2 and pH Cascade-Triggered Insulin Delivery. , 2018, Small.

[210]  W. Gaertner.  Frequency Dependence of Ultrasonic Cavitation , 1954 .

[211]  Takaya Miyano,et al.  Sugar Micro Needles as Transdermic Drug Delivery System , 2005, Biomedical microdevices.

[212]  K. Tachibana,et al.  Transdermal delivery of insulin by ultrasonic vibration , 1991, The Journal of pharmacy and pharmacology.

[213]  Eneko Larrañeta,et al.  Microarray patches: potentially useful delivery systems for long-acting nanosuspensions. , 2017, Drug discovery today.

[214]  Ran Liu,et al.  Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[215]  Zhen Gu,et al.  Emerging micro- and nanotechnology based synthetic approaches for insulin delivery. , 2014, Chemical Society reviews.

[216]  Mei-Chin Chen,et al.  Near-Infrared Light-Activatable Microneedle System for Treating Superficial Tumors by Combination of Chemotherapy and Photothermal Therapy. , 2016, ACS nano.

[217]  Wolfgang Becker,et al.  Nanoparticles and microparticles for skin drug delivery. , 2011, Advanced drug delivery reviews.

[218]  Zhen Gu,et al.  Microneedles Integrated with Pancreatic Cells and Synthetic Glucose‐Signal Amplifiers for Smart Insulin Delivery , 2016, Advanced materials.

[219]  Majella E Lane,et al.  Skin penetration enhancers. , 2013, International journal of pharmaceutics.

[220]  Robert Langer,et al.  Bioresponsive materials , 2016 .

[221]  S. Hui,et al.  Synergistic effect of anionic lipid enhancer and electroosmosis for transcutaneous delivery of insulin. , 2006, International journal of pharmaceutics.

[222]  Hyungil Jung,et al.  Droplet-born air blowing: novel dissolving microneedle fabrication. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[223]  Raptis Sa,et al.  Efficacy of a new needleless insulin delivery system monitoring of blood glucose fluctuations and free insulin levels. , 1989 .

[224]  Samir Mitragotri,et al.  Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies , 2014, Nature Reviews Drug Discovery.

[225]  Damijan Miklavčič,et al.  Electroporation-based technologies for medicine: principles, applications, and challenges. , 2014, Annual review of biomedical engineering.

[226]  Yuqin Qiu,et al.  Enhanced transcutaneous immunization via dissolving microneedle array loaded with liposome encapsulated antigen and adjuvant. , 2013, International journal of pharmaceutics.

[227]  R. Meyer,et al.  Rectangular cymbal arrays for improved ultrasonic transdermal insulin delivery. , 2007, The Journal of the Acoustical Society of America.

[228]  S. Mitragotri,et al.  Ultrasound-mediated transdermal protein delivery , 1995, Science.

[229]  Pianpian Ma,et al.  Glucose- and H2O2-Responsive Polymeric Vesicles Integrated with Microneedle Patches for Glucose-Sensitive Transcutaneous Delivery of Insulin in Diabetic Rats. , 2018, ACS applied materials & interfaces.

[230]  Denise O'Connor,et al.  Cochrane review: Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus , 2010 .

[231]  F. Patat,et al.  Transdermal delivery of insulin using low frequency ultrasound , 2000, 2000 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.00CH37121).

[232]  F. Jolesz.  MRI-guided focused ultrasound surgery. , 2007, Annual review of medicine.

[233]  Zhefu Chen,et al.  Organization of glucose-responsive systems and their properties. , 2011, Chemical reviews.

[234]  J. Shaw,et al.  Global estimates of diabetes prevalence for 2013 and projections for 2035. , 2014, Diabetes Research and Clinical Practice.

[235]  Y. Kalia,et al.  Transdermal drug delivery: overcoming the skin's barrier function. , 2000, Pharmaceutical science & technology today.

[236]  K. Suslick,et al.  Applications of Ultrasound to Materials Chemistry , 1995 .

[237]  M. Pikal,et al.  The role of electroosmotic flow in transdermal iontophoresis. , 1992, Advanced drug delivery reviews.

[238]  J. Denuzzio,et al.  Electrochemical and iontophoretic studies of human skin , 1990 .

[239]  Eric W. Smith,et al.  The role of percutaneous penetration enhancers , 1996 .

[240]  Naresh Kumar,et al.  Transdermal iontophoresis of insulin. Part 1: A study on the issues associated with the use of platinum electrodes on rat skin , 2003, The Journal of pharmacy and pharmacology.

[241]  Ryan F Donnelly,et al.  Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[242]  Zhen Gu,et al.  Core-Shell Microneedle Gel for Self-Regulated Insulin Delivery. , 2018, ACS nano.

[243]  M. Prausnitz,et al.  Minimally invasive insulin delivery in subjects with type 1 diabetes using hollow microneedles. , 2009, Diabetes technology & therapeutics.

[244]  Mark G. Allen,et al.  Hollow metal microneedles for insulin delivery to diabetic rats , 2005, IEEE Transactions on Biomedical Engineering.

[245]  O. Pillai,et al.  Transdermal iontophoresis of insulin. V. Effect of terpenes. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[246]  Xianfeng Chen.  Current and future technological advances in transdermal gene delivery☆ , 2017, Advanced drug delivery reviews.

[247]  L. John,et al.  Blood glucose control in diabetic rats by transdermal iontophoretic delivery of insulin , 1988 .

[248]  B. Kári.  Control of Blood Glucose Levels in Alloxan-diabetic Rabbits by Iontophoresis of Insulin , 1986, Diabetes.

[249]  Eneko Larrañeta,et al.  Dissolving microneedles: safety considerations and future perspectives. , 2016, Therapeutic delivery.

[250]  J. Birchall,et al.  Low temperature fabrication of biodegradable sugar glass microneedles for transdermal drug delivery applications. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[251]  K. Tachibana.  Transdermal Delivery of Insulin to Alloxan-Diabetic Rabbits by Ultrasound Exposure , 1992, Pharmaceutical Research.

[252]  Kanji Takada,et al.  Feasibility of microneedles for percutaneous absorption of insulin. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[253]  C. Tack,et al.  Pharmacokinetic and Pharmacodynamic Variability of Insulin When Administered by Jet Injection , 2017, Journal of diabetes science and technology.

[254]  Kaushalkumar Dave,et al.  Microneedles in the clinic. , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[255]  Seungpyo Hong,et al.  Nanoscale polymeric penetration enhancers in topical drug delivery , 2013 .

[256]  O. Pillai,et al.  Stability of insulin under iontophoretic conditions. , 2006, Die Pharmazie.

[257]  Guohua Jiang,et al.  Microneedles fabricated from alginate and maltose for transdermal delivery of insulin on diabetic rats. , 2018, Materials science & engineering. C, Materials for biological applications.

[258]  A. Ghanem,et al.  Studies on the Effects of Applied Voltage and Duration on Human Epidermal Membrane Alteration/Recovery and the Resultant Effects upon Iontophoresis , 1994, Pharmaceutical Research.

[259]  A. Doukas,et al.  Photomechanical transdermal delivery of insulin in vivo , 2001, Lasers in surgery and medicine.